POEMS syndrome is an unusual multisystem disorder associated with polyneuropathy, organomegaly, endocrinopathy, M protein(monoclonal protein) in plasma and skin change, The pathogenesis of this syndrome has not been fully explained.

Since 1938, about two hundred cases have been reported in other countries and there were a few reports of polyneuropathy associated with POEMS syndrome in Korea.

We experienced a case with quadriparesis due to polyneuropathy accompanied by nonspecific hepatosplenomeglay, hypothyroidism, skin change such as hyperpigmentation and plasma cell dyscrasia, Clinical syndrome, signs, electrodiagnostic findings, findings of bone marrow biopsy, and histopathologic findings of lymph node and skin in this rare case were reviewed