| The Significance of Evoked Potentials according to the Injury Severity of Spinal Cord Contusive Rat Model. |
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Lee, So Young , Kim, Ji Hoon , Cheon, Seung Wook , Kim, Jae Hyung , Choi, In Sung , Lee, Sam Gyu , Jeon, Pyeung Sik , Kim, Hyung Beom , Park, Seung Jin |
1Department of Physical Medicine & Rehabilitation, Chonnam National University Medical School, Korea. sam91@jnu.ac.kr
2Department of Physical Medicine & Rehabilitation, Chonnam National University Hwasun Hospital, Korea.
3Department of Physical Medicine & Rehabilitation, Gwangju Christian Hospital, Korea.
4Department of Biomedical Engineering, Chonnam National University Hospital, Korea. |
| 척수좌상 백서모델에서 손상정도에 따른 유발전위 검사의 의의 |
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이소영1, 김지훈, 천승욱, 김재형1, 최인성, 이삼규, 전평식2, 김형범3, 박승진3 |
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전남대학교 의과대학 재활의학교실, 1화순전남대학교병원 재활의학과, 2광주기독병원 재활의학과, 3전남대학교병원 의공학과 |
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| Abstract |
Objective
To investigate the prognostic values of somatosensory evoked potential (SEP) and electric motor evoked potential (eMEP) studies according to the varying spinal cord injury by incremental height of weight-drop impactor and progress of functional recovery
Method
Thirty Sprague-Dawley rats (300⁑50 grams, male) were used. The spinal cord injury was made by weight-drop device from 12.5, 25.0 and 50.0 mm height at T10 cord segment. The three groups of each drop-height (n=10) and laminectomized sham group (n=10) were subjected to functional analysis using inclined plane test and Basso Beattie Bresnahan (BBB) locomotor scales at the 1, 3, 5, 7, 14, 21 and 28th day after the contusive injury. SEP by sciatic nerve stimulation and eMEP at the gastrocnemiusmuscle were recorded.
Results
Maximal angle of inclination and BBB scales had an inverse relation with the contusion severity (p＜0.05). There were significant correlations among the changes of peak latencies and amplitudes of SEP, contusion severity, and the motor recovery (p＜0.05). The changes of onset latencies and amplitudes of eMEP were significantly correlated with the contusion severity and the motor recovery (p＜0.05).
Conclusion
The SEP and eMEP studies had significant values according to the contusion severity and functional recovery in contusive rat model of the spinal cord. (J Korean Acad Rehab Med 2005; 29: 201-208) |
| Key Words:
Spinal cord contusion, Somatosensory evoked potential, Electric motor evoked potential, Functional recovery, Spinal cord contusive rat model |
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