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Journal of the Korean Academy of Rehabilitation Medicine 2006;30(4):378-384.
The Effects of Anti-inflammatory Drugs on Histologic Findings of the Experimental Prolotherapy Model.
Kim, Hyun Jung , Kim, Se Hoon , Yun, Dong Hwan , Lee, Kang Sik , Jeong, Tae Seok
1Department of Rehabilitation Medicine, Eulji Hospital, Eulji University School of Medicine, Korea. cynikid@naver.com
2Department of Pathology, Yonsei University College of Medicine, Korea.
3Department of Physical Medicine & Rehabilitation Medicine, Andong General Hospital, Korea.
항염증제제가 실험적 증식치료 모델의 조직 소견에 미치는 영향
김현정, 김세훈1, 윤동환, 이강식, 정태석2
을지의과대학교 재활의학교실, 1연세대학교 의과대학 병리학교실, 2안동병원 재활의학과
To investigate the effects of nonsteroidal anti- inflammatory drugs (NSAIDs) and acetaminophen on histologic changes of the Achilles tendon in an experimental prolotherapy model.
The right Achilles tendon of 60 rats was injected with 20% dextrose on experimental day 1, 7, and day 14, whereas the left was not injected and used as control. Rats were divided into 3 subgroups: NSAIDs medication group (10 mg/kg/day), acetaminophen medication group (100 mg/ kg/day) and no medication group. Medications were given for 3 consecutive days after each injection. Rats were sacrificed at 3 and 6 weeks after first injection. The transverse diameter of gross specimen, the number of fibroblasts on light microscope, and the distribution of collagen fibril on electron microscope were assessed.
The transverse diameter and the count of fibroblasts of all groups increased significantly in the injected tendon compared to the non-injected tendon. However, there were no differences among all groups significantly (p<0.05). On electron micrograph, fibril diameters of injected tendon consisted of mainly smaller sizes with the intermediate sizes.
Prolotherapy enhances fibroblastic stimulation and elaboration of extracellular matrix. Short term use of NSAIDs may not have any adverse effects on tissue proliferation after prolotherapy. (J Korean Acad Rehab Med 2006; 30: 378-384)
Key Words: Prolotherapy, Nonsteroidal anti-inflammatory drugs, Acetaminophen, Tendon


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