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Journal of the Korean Academy of Rehabilitation Medicine 1999;23(1):109-116.
The Effect of Hyaluronic Acid and Steroid in the Experimental Osteoarthritis.
Han, Tai Ryoon , Choi, Kyoung Hyo
1Department of Rehabilitation Medicine, Seoul National University College of Medicine.
2Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine.
실험적 퇴행성 골관절염에서의 Hyaluronic Acid와 Steroid의 효과
한태륜, 최경효1
서울대학교 의과대학 및 1울산대학교 의과대학 서울중앙병원 재활의학교실
Abstract

Objective
Hyaluronic acid is a naturally occurring glycosaminoglycan which, by virtue of its viscosity, elasticity and other theological properties, acts as lubrication and shock absorbing fluid in joints. In addition to its lubrication and cushioning properties, hyaluronic acid has been associated with in vitro anti-inflammatory activity and possible disease-modifying effect in animals. The purpose of this study was to evaluate the effect of intraarticular injection of hyaluronic acid or steroid on the healing of the experimental degenerative osteoarthritis and the therapeutic synergism between the hyaluronic acid and steroid.


Method
48 rabbits with experimental osteoarthritis produced by extension immobilization of knees were treated with hyaluronic acid and/or steroid and then assessed clinically, radiologically, scintigraphically and histopathologically at pre and post treatment.


Results
The hyaluronic acid treated group had more favorable results than other groups but the results were not statistically significant. The steroid treated group did not have significant change in comparison to the control group. Therapeutic synergism between hyaluronic acid and steroid was not found.


Conclusions
The results of this study indicate that the intraarticular injection of hyaluronic acid may be effective for the treatment of patients with osteoarthritis.

Key Words: Hyaluronic acid, Steroid, Degenerative arthritis


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