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Journal of the Korean Academy of Rehabilitation Medicine 1996;20(1):5.
The Effect of Home Exercise Program for Patients with Myotonic Dystrophy
Young Moo Na, M.D., Seong Woong Kang, M.D., Han Soo Lee, M.D. , Jae Ho Moon, M.D.
Department of Rehabilitation Medicine, Yonsei Univesity College of Medicine
근긴장증성 디스트로피 환자에 대한 가정 운동 프로그램의 효과
나영무, 강성웅, 이한수, 문재호
연세대학교 의과대학 재활의학교실
Abstract

Myotonic dystrophy is a muscular disorder characterized by muscle weakness and myotonia. Myotonia menifest as abnormally slow relaxation after strong voluntary contraction. So patients with myotonic dystrophy are difficult to perform activities of daily living. In our previous study we reported that quinine sulfate therapy not combined with muscle strengthening exercise provided therapeutic benifit to myotonia but not muscle weakness. The purpose of this study was to determine the effect of six-month home exercise program based on muscle strengthening exercise. Seven patients with myotonic dystrophy trained daily for six months at home with weights adapted to their force or without any tools and received one gram of quinine sulfate daily for six months. The changes of muscle strength and relaxation times between pretherapy and post-quinine sulfate therapy and post-six-month home exercise program combined with quinine sulfate therapy were assessed from the first dorsal interossei, elbow flexors, and knee extensors. The results were as follows: ① The improvement of the mean muscle strengh of the elbow flexors, and knee extensors was significant compared with pretherapy and post-quinine sulfate therpay. ② The improvement of the mean muscle strength of the first dorsal interossei was slight but not significant compared with pretherapy and post-quinine sulfate therapy. ③ The shortening of relaxation times of the three muscles was significant compared with pretherapy. ④ The shortening of relaxation times of the three muscles was slight but not significant compared with post-quinine sulfate therapy. In conclusion, home exercise program based on muscle strenghening exercise combined with quinine sulfate therapy showed significant improvement of the muscle strength and shortening of relaxation times for the patients with myotonic dystrophy.

Key Words: Quinine sulfate, Myotonic dystrophy, Muscle strength, Relaxation time, Exercise, Quinine sulfate


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