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Journal of the Korean Academy of Rehabilitation Medicine 1994;18(3):29.
Effect of Transdermal Clonidine on Spasticity in Spinal Cord Injury
Seung Han Yang, M.D., Sae Yoon Kang, M.D., Jung Suh, M.D. , Keun Young Park, M.D.
Department of Rehabilitation Medicine, Catholic University College of Medicine
척수 손상으로 인한 경직에 경피 투여된 Clonidine의 효과 -2례 보고-
양승한, 강세윤, 서정, 박근영
가톨릭대학교 의과대학 재활의학교실
Abstract

Clonidine, centrally acting α2 agonist, has been used as an antihypertensive agent. Although antispastic action of clonidine has been known, the clinical use of oral clonidine on spinal spasticity has been limited due to side effects, mainly postural hypotension. Two cases are presented of patients with spasticity as the result of cervical spinal cord injury, inadequately managed by oral baclofen & other conservative treatment, in whom transdermal clonidine was administered. Dramatic relief in spasticity and increment in functional level were achieved in both of 2 cases with side effect limited to dryness of the mouth in one case. In addition to improvement in spasticity, there was amelioration of paresthesia in one case.

Key Words: Spasticity, Spinal cord injury, Clonidine


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