Titration of Phenol Nerve Block Effects on Peripheral Nerves: Electrophysiologic and Mechanical Measurements. |
Sung, Duk Hyun , Park, Won Hah , Bang, Hee Je , Kim, Jong Moon , Kim, Tae Uk , Chung, Seung Hyun , Woo, Eung Je |
1Department of Physical Medicine and Rehabilitation, Samsung Medical Center, Sungkyunkwan University School of Medicine. 2Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine. 3Department of Biomedical Engineering, College of Medicine, Konkuk University. |
페놀 차단술의 말초 신경 차단 효과의 적정화 전기생리학적 및 역학적 측정 |
성덕현, 박원하1, 방희제, 김종문, 김태욱, 정승현, 우응제2 |
성균관대학교 의과대학 재활의학교실, 1정형외과학교실, 2건국대학교 의과대학 의용생체공학부 |
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Abstract |
Objective The purpose of this study was to titrate the nerve block effect of phenol with different concentrations of phenol solution by electrophysiological and mechanical measurements. Method Right tibial nerves of twenty three adult rabbits were blocked by phenol solution with different concentrations (3%, 5%). Nerve conduction study for compound muscle action potential (CMAP), tension by electrical stimulation, and stiffness (slope) of stretch reflex of the triceps surae were performed after nerve block (4 weeks, 8 weeks, 16 weeks). The ratios of each values of right limb to those of left limb were used to evaluate the nerve block effect. Results The ratios of CMAP amplitude, tension, and slope of 3% group were 0.36, 0.55, and 0.56 at 4 weeks and those of 5% group were 0.21, 0.25, and 0.58. There were statistically significant differences of the CMAP amplitude and tension ratios, however there was no statistically significant difference of the slope ratio between two groups at 4 weeks. The ratios of CMAP amplitude, tension, and slope of 5% phenol group were increased with time. Conclusion Nerve block effects by 5% phenol solution were greater than 3%. These data suggest that nerve block effect can be titrated with concentration of phenol solution. |
Key Words:
Phenol, Nerve block, Titration, CMAP, Tension, Stretch reflex |
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