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Journal of the Korean Academy of Rehabilitation Medicine 1999;23(6):1155-1161.
Effect of Clonidine on Spasticity in Patients with Spinal Cord Injury.
Shin, Ji Cheol , Park, Chang Il , Kim, Deog Young , Yoon, Tae Jun , Kim, Yong Kyun , Seo, Cheong Hoon , Choi, Young Seok
1Department of Rehabilitation Medicine, Yonsei University College of Medicine.
2Research Institute of Rehabilitation, Yonsei University College of Medicine.
척수손상 환자의 경직에 대한 Clonidine의 효과
신지철, 박창일, 김덕용, 윤태준, 김용균, 서정훈, 최용석
연세대학교 의과대학 재활의학교실 및 재활의학 연구소
Abstract

Objective
Spasticity has been reported to be one of the common complications in patients with spinal cord injury. The purposes of this study were to investigate the proper dosage, the therapeutic and undesirable effects of clonidine with combined used of baclofen for the management of spasticity.


Method
A prospective study was performed for 17 patients with spinal cord injury who did not improve spasticity with 80 mg baclofen administration. The degree of spasticity was assessed in the more-affected knee by modified Ashworth scale, pendulum test at pre-treatment and at 7 days after receiving clonidine. We also investigated the complications and subjective satisfaction.


Results
Seven of 13 patients with spinal cord injury showed subjective improvement in spasticity. We found significant improvement in the relaxation index by pendulum test after administration of more than 0.3 mg of clonidine. There was no significant difference between the subgroups depending on the extent of spinal cord injury. We didn't find any serious complication in adjuvant clonidine therapy.


Conclusion
Adjuvant clonidine therapy can be effective in spasticity of spinal cord injured patients without serious complication.

Key Words: Spasticity, Spinal cord injury, Clonidine, Pendulum test


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