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Journal of the Korean Academy of Rehabilitation Medicine 2003;27(2):250-254.
Effects of Exercise Therapy on Natural Killer Cell Cytotoxic Activity in Breast Cancer Patients after Curative Surgery.
Na, Young Moo , Lim, Kil Byung , Lee, Hong Jae , Kim, Yong Kyun , Lee, Yoon Jeong , Lee, Hue Dae , Lee, Geon Cheol
1Department of Rehabilitation Medicine, Inje University Ilsan Paik Hospital, Korea. yacha@hanmail.net
2Department of Rehabilitation Medicine, Yonsei University College of Medicine, Korea.
3Department of General Surgery, Yonsei University College of Medicine, Korea.
4Department of Physical Therapy, Kyung-Nam College of Information & Technology, Korea.
수술 후 유방암 환자에서 운동치료가 자연살세포 활성도에 미치는 영향
나영무, 임길병, 이홍재, 김용균, 이윤정1, 이희대2, 이건철3
인제대학교 의과대학 재활의학교실, 연세대학교 의과대학 1재활의학교실, 2외과학교실, 3경남 정보기술대학 물리치료과
Exercise may contribute to alteration in cancer in many ways. The major cell in cellular immunity to defense against cancer cell is natural killer [NK] cell. So this study is aimed to investigate the effects of exercise on NK cell cytotoxic activity (NKCA) in breast cancer patients who underwent mastectomy.

Thirty-one breast cancer patients who had undergone curative surgery were randomly assigned to an exercise group (n=16) and a non-exercise group (n=15). Exercise therapy was consisted of aerobic activity such as bicycle ergometer for 30 minutes, twice a day, five times each week for 2 weeks. The venous blood samplings were obtained on postoperative days 1, 7 and 14. NKCA was assayed by cytotoxic response against K562 cells. The venous blood samplings were obtained on postoperative days 1, 7 and 14. NKCA was assayed by cytotoxic response against K562 cells.

The baseline study did not show any statistical difference between exercise group and non-exercise group. Mean NKCA of day 7 decreased in both groups compared with that at postoperative day 1 (p<0.05). At day 14, the difference of the mean NKCA between two groups was not significant, but the mean NKCA of the exercise group without metastasis demonstrated a significant increase compared with that of the non-exercise group without metastasis (p<0.05).

This study suggested that early moderate exercise had a beneficial effect on the function of NK cells in early stage of breast cancer patients after curative surgery. A further study will be needed to evaluate long-term effect of exercise on NK cell. (J Korean Acad Rehab Med 2003; 27: 250-254)

Key Words: Natural killer cell cytotoxic activity, Breast cancer, Exercise therapy, Cancer rehabilitation


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