| Histological Changes after Intradiscal Steroid Injection to the Intervertebral Disc in Disc Injury Rabbit Model. |
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Park, Jae Heung , Ko, Hyun Yoon , Ahn, Young Hyun , Lee, Chang Hoon |
1Department of Rehabilitation Medicine, Pusan National University College of Medicine. jheung@pusan.ac.kr
2Department of Pathology, Pusan National University College of Medicine. |
| 추간판 손상 토끼 모델에서 추간판 내에 스테로이드 주사 후 조직 변화 |
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박재흥, 고현윤, 안영현, 이창훈1 |
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부산대학교 의과대학 재활의학교실, 1병리학교실 |
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| Abstract |
Objective
To evaluate the degeneration changes of disc injury rabbit model produced by needle puncture to intervertebral disc and to observe the histological changes of the degenerated disc treated with intradiscal steroid.
Method
The subjects were composed of 10 L4-5 intervertebral discs (study group) and 10 L3-4 intervertebral discs (control group) of Newzealand white rabbits. The rabbits' discs were exposed by anterior approach and degeneration was elicited by 21 G needle puncture. After 4 weeks, the study group was injected with 0.2 ml triamcinolone acetonide (Tamcetone 40 mg/ml) and the control group was injected with 0.2 ml normal saline, intradiscally. The discs were extracted on 4 weeks after degeneration and stainedwith Hematoxylin-Eosin and investigated by light microscopy.
Results
Degenerative changes, including fissuring and focal fibrosis, were elicited in the all groups, but there were no significant histological differences between the two groups.
Conclusion
We concluded that the degenerative changes are well observed in disc injury rabbit model. The mollification of discogenic pain following intradiscal steroid injection in practice may not be explained from light microscopic histological changes of the disc. Further biochemical or electromicroscopic study will be necessary to clarify the mechanism of alleviation of discogenic pain by intradiscal steroid. (J Korean Acad Rehab Med 2006; 30: 51-56) |
| Key Words:
Intradiscal steroid injection, Discogenic pain, Histological change, Disc degeneration |
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