The Effects of Dilution Volume of Botulinum Toxin A on the Spasticity of Children with Cerebral Palsy.

, Rhim, Seung Yoon; , Kim, Mi Jung; , Han, Seung Hoon

Original Article

Journal of the Korean Academy of Rehabilitation Medicine 2008;32(3):294-299.

Rhim, Seung Yoon , Kim, Mi Jung , Han, Seung Hoon

Department of Rehabilitation Medicine, Hanyang University College of Medcine, Korea. stephan72@hanmail.net

보툴리눔 독소의 희석 용적에 따른 뇌성마비 환아의 경직의 변화

임승윤, 김미정, 한승훈

한양대학교 의과대학 재활의학교실

Abstract

Objective
To evaluate the effects of the dilution volume of botulinum toxin A on spasticity of children with cerebral palsy.
Method
Total 18 legs of 9 children with cerebral palsy were enrolled. 100 units of botulinum toxin were diluted with 4 cc or 2 cc of normal saline and injected to the medial and lateral heads of Gastrocnemius. Modified Ashworth scale, modified Tardieu test and range of motion (ROM) of ankle and knee were measured. Measurements were obtained before and at 1, 7, 14, 30, 60, 90, and 180 days after injection, respectively.
Results
Spasticity tested by modified Ashworth scale and modified Tardieu test decreased and ROM of ankle and knee increased after 14 days since injection in both groups (p＜0.05). In low dilution group, maximal ROM of ankle and knee was obtained at 30^th day after injection. In high dilution group, maximal ROM of ankle and knee was achieved at 14^th day after injection and maximal ROM of knee at 30^th day after injection. However, there was no significant differences between high dilution group and low dilution group in different times.
Conclusion
Management of spasticity with botulinum toxin in cerebral palsy was not related to dilution volume. (J Korean Acad Rehab Med 2008; 32: 294-299)

Key Words: Cerebral palsy, Botulinum toxin A, Spasticity, Children, Dilution