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Information- Original Article
- J Korean Acad Rehabil Med. 2003;27(2):250-254.
- Effects of Exercise Therapy on Natural Killer Cell Cytotoxic Activity in Breast Cancer Patients after Curative Surgery.
- Na, Young Moo , Lim, Kil Byung , Lee, Hong Jae , Kim, Yong Kyun , Lee, Yoon Jeong , Lee, Hue Dae , Lee, Geon Cheol
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1Department of Rehabilitation Medicine, Inje University Ilsan Paik Hospital, Korea. yacha@hanmail.net
2Department of Rehabilitation Medicine, Yonsei University College of Medicine, Korea.
3Department of General Surgery, Yonsei University College of Medicine, Korea.
4Department of Physical Therapy, Kyung-Nam College of Information & Technology, Korea.
- Abstract
- Objective
Exercise may contribute to alteration in cancer in many ways. The major cell in cellular immunity to defense against cancer cell is natural killer [NK] cell. So this study is aimed to investigate the effects of exercise on NK cell cytotoxic activity (NKCA) in breast cancer patients who underwent mastectomy.Method: Thirty-one breast cancer patients who had undergone curative surgery were randomly assigned to an exercise group (n=16) and a non-exercise group (n=15). Exercise therapy was consisted of aerobic activity such as bicycle ergometer for 30 minutes, twice a day, five times each week for 2 weeks. The venous blood samplings were obtained on postoperative days 1, 7 and 14. NKCA was assayed by cytotoxic response against K562 cells. The venous blood samplings were obtained on postoperative days 1, 7 and 14. NKCA was assayed by cytotoxic response against K562 cells.
Results: The baseline study did not show any statistical difference between exercise group and non-exercise group. Mean NKCA of day 7 decreased in both groups compared with that at postoperative day 1 (p＜0.05). At day 14, the difference of the mean NKCA between two groups was not significant, but the mean NKCA of the exercise group without metastasis demonstrated a significant increase compared with that of the non-exercise group without metastasis (p＜0.05).
Conclusion: This study suggested that early moderate exercise had a beneficial effect on the function of NK cells in early stage of breast cancer patients after curative surgery. A further study will be needed to evaluate long-term effect of exercise on NK cell. (J Korean Acad Rehab Med 2003; 27: 250-254)
Keywords :Natural killer cell cytotoxic activity, Breast cancer, Exercise therapy, Cancer rehabilitation