Annals of Rehabilitation Medicine

Case Report: J Korean Acad Rehabil Med. 2003;27(2):275-279.; The Resininferatoxin Therapy for the Hyperreflexive Neurogenic Bladder: Report of two cases of spinal cord injured patients.; Park, Joo Hyun , Park, Geun Young , Lee, Be Na , Sung, Jin Young; Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Korea. serrom@hanmail.net

Abstract: Resiniferatoxin, a substance isolated from some species of Euphorbia, a cactus-like plant, shows pharmacological effects similar to those of capsaicin. We administered resiniferatoxin for treating detrusor hyperreflexia to patient with chronic spinal cord injury. Resiniferatoxin solution (100 ml at a concentration of 10^⁣7, 10^⁣6 M) was instilled twice into the bladder of patient with detrusor hyperreflexia and left in place for 30 minutes. Effects on bladder function were monitored at 1 month later follow-up. One month after the last resiniferatoxin instillation, patients reported a significant symptomatic improvement of their incontinence and increased mean bladder capacity. (J Korean Acad Rehab Med 2003; 27: 275-279)

Keywords :Resiniferatoxin, Detrusor hyperreflexia, Neurogenic bladder, Spinal cord injury