Annals of Rehabilitation Medicine

Original Article: J Korean Acad Rehabil Med. 2004;28(5):412-417.; Influence of Lesion Location on Cortical Recovery Pattern in Hemiparetic Stroke Patients.; Jang, Sung Ho , Son, Su Min , Ahn, Sang Ho , Cho, Sang Hyun , Jang, Han Won , Cho, Yun Woo , Yang, Dong Seok , Lee, Dong Gyu; ¹Department of Physical Medicine and Rehabilitation, Yeungnam University College of Medicine, Korea. sumin430@hanmail.net
²Department of Physical Therapy, Yonsei University College of Health Science, Korea.
³Department of Diagnostic Radiology, Yeungnam University College of Medicine, Korea.

Abstract: Objective
The aim of this study was to elucidate how the location of cerebral infarct influences cortical recovery pattern in hemiparetic stroke patients.Method: Forty-three chronic stroke patients and 21 control subjects were recruited for the study. The patients were classified into 4 groups according to infarct locations: cortex (CO), corona radiata (CR), posterior limb of the internal capsule (PL), and brainstem (BS). Functional MRI was performed using the blood oxygen level-dependent technique at 1.5 T with the motor task of hand grasp-release movements.Results: The activation pattern of the primary sensori-motor cortex (SM1) was found to be significantly influenced by the lesion locations, but that of the secondary motor area was not (Pearson's chi-square test, p＜0.05). The 'contralateral' SM1 activation was the major response in the control group (85.7%) and in the BS group (75.0%). On the other hand, the major activation pattern was 'peri-lesional' in the CO group (peri-lesional 57.1%, peri-lesional and ipsilateral 42.9%), 'bilateral activation' in the CR (85.7%) and the PL group (100.0%).Conclusion: Our results suggested that motor recovery mechanisms could be different according to location of cerebral infarct. (J Korean Acad Rehab Med 2004; 28: 412-417)

Keywords :Functional magnetic resonance imaging, Stroke, Motor recovery, Hemiplegia