This study was designed to evaluate the clinical value of ^99mTc HMPAO (Hexamethyl Propylene Amine Oxyme) brain SPECT (Single Photon Emission Computed Tomography) in visualization of topographical involvement of cerebral palsy. Ten children with cerebral palsy (4: spastic diplegia, 2: spastic quadriplegia, 2: athetoid quadriplegia, 2: hemiplegia) were studied. The results showed that SPECT abnormalities were congruent in most cases with their to pographical involvement of disabilities, despite of no correlative abnormality demonstrated by conventional radiological studies including CT or MRI. These results indicated that ^99mTc HMPAO brain SPECT might have a potential clinical value in visualization of related site and extent with topographical disabilities.