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Journal of the Korean Academy of Rehabilitation Medicine 1994;18(4):19.
A Study on the Influence of Lidocaine and/or Fentany1 to Nerve Conduction Study
Young Ho Koh, M.D.. Seong Eun Koh, M.D.. Soon Yeol Chong, M.D.. , Jin Sang Chung, M.D.
Department of Rehabilitation Medicine, Kon-Kuk University, College of Medicine

and Literature Chonbuk National University

Lidocaine과 Fentany1이 신경 전도에 미치는 영향
고영호, 고성은, 정순열, 정진상
건국대학교 의과대학 부속병원 재활의학과
Abstract

Lidocaine and fentany1 are frequently used as analgesic agents or blockers of pathway. To evaluate the influence of lidocaine and/or fentany1 to nerve conduction, we divided 29 wistar rats(200~300gm) into four groups such as 4% lidocaine(2mg/100g) dripping, mixed solution(4% lidocaine and fentany1) dripping, fentany1(2.5ug/100g) dripping, saline solution dripping. Rats were anesthetized with ether and pentothal sodium(2mg/100g) and their sciatic nerves were surgically exposed and were dripped with experimental solution according to groups. Sensory nerve action potentials(SNAP) were examined according to time sequence such as pre-dripping, post-dripping 2 min., 5 min., 10 min., 20 min., 30 min respectively.

The results were as follows:

1) Significantly prolonged latencies and decreased amplitudes were noted in 2 min., 5 min., 10 min., and 20 min. after dripping of lidocaine as compared to that of pre-dripping, respectively (p>0.05)

2) Significantly prolonged latencies were noted in 2 min., 5 min., 10 min., 20 min., and significantly decreased amplitudes were noted in 5 min., 10 min., after dripping of mixed solution as compared to that of pre-dripping, respectively (p<0.05)

3) There was no significant change between pre-and post-dripping of fentany1 or saline solution, respectively (p>0.05).

So we concluded that lidocaine or mixed solution(lidocaine and fentany1) was effective in blocking of nerve conduction, but synergic effects of fentany1 addition was not observed in nerve conduction study.

Key Words: Lidocaine, Fentanyl, Sensory nerve action potential


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