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Journal of the Korean Academy of Rehabilitation Medicine 1994;18(2):3.
Local Steroid Effect on Recovery of Acute Conduction Block of Rat Caudal Nerve
Sang Heon Lee, M.D. , Hee Kyu Kwon, M.D.
Department of Rehabilitation Medicine, Korea University College of Medicine
백서 미부신경에서 급성 신경전도차단의 회복에 대한 국소 스테로이드 주사효과
이상헌, 권희규
고려대학교 의과대학 재활의학교실

Local steroid injection to the recently compressed nerve might facilitate the recovery of conduction block. Steroid relieves high-tissue pressure secondary to inflammatory reaction such as edema or cell infiltration.

The purpose of the study was to investigate the effect of local steroid injection in acute experimental compression neuropathy with complete conduction block of the caudal nerves of 31 rats. The day after compression, the compression site was injected with 0.4 mL dexamethasone acetate (4 mg/mL suspension) in eleven rats (group A), and 0.4 mL normal saline in another eight rats (group B). The remaining twelve rats (group C) received no injection. The amplitudes of the compound muscle action potential (CMAP) and motor nerve conduction velocity (NCV) over the compression segment were measured before and after nerve compression. The recovery rate of amplitude of CMAP and NCV in group A was significantly higher than that in groups B or C (p<0.05).

Key Words: Steroid, Conduction block, Compression neuropathy


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