Of the various entrapment neuropathies, we can meet the Carpal Tunnel Syndrome most frequently in clinic. And the development of electrophysiological study enables us to diagnose Tarsal Tunnel Syndrome more easily, so we can experience these cases occasionally.

Generally, entrapment neuropathies are classified into two main causes, the one is localized problem and the other is systemic one. The systemic causes have been said that they are accompanied with various diseases such as rhumatoid arthritis, ankylosing spondylitis, diabetes mellitus, etc. So special and precise studies for their differential diagnosis are required.

In addition, entrapment neuropathies combined with hyperlipidemia has been hardly reported yet, and the reports for these cases are very rare at home and abroad. Now, this paper reports two cases which had been diagnosed as Tarsal Tunnel Syndrome accompanying hyperlipidemia and diabetes mellitus, and also reports for the relationship between hyperlipidemia and entrapment neuropathies, their pathology, and book review.