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Journal of the Korean Academy of Rehabilitation Medicine 1993;17(3):354-361.
Antigen-induced arthritis in rabbits.
Kim, Jin Ho , Han, Tai Ryoon , Lee, Kyoung Moo
Department of Rehabilitation Medicine, Seoul National University College of Medicine, Department of Rehabilitation Medicine, Chungbuk National University College of Medicine
가토에서 이종 단백질에 의한 면역성 유발 관절염에 대한 연구
김진호, 한태륜, 이경무
서울대학교 의과대학 재활의학교실, 충북대학교 의과대학 재활의학교실

A total of eighty rabbits were immunized with bovine serum albumin or ovalbumin by intradermal injections of antigen-adjuvant emulsion. Level of antibody to the injected antigen was increased about 5 weeks after injection. Intra-articular antigen injections in the knee joints were done to each rabbit by 8 week after first immunization.

An arthritis-score system was established to evaluate the inductivity of knee-arthritis, and such induced signs of inflammation in the joints.

Increase in joint diameter, temperature elevations, erythemas were noted on the knee joint after intra-articular injection. The arthritis-score was higher in ovalbumin-treated group.

Microscopically, the synovial membrane showed hyperplasias, inflammatory cell infiltrations, lymphoid follicle formations and capillary dilatations.

Key Words: Rabbit, Antigen, Arthritis
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