Vasculitis is a clinico-pathological process characterized by inflammation and necrosis of blood vessels. The clinical spectrum ranges from a primary disease process restricted to blood vessels in the absence of an underlying disease to a secondary component of the primary disease. We experienced a case of polyarteritis nodosa who complained of progressive pain and weakness in back and lower extremities. Polyarteritis nodosa should be considered as one of the causes of pain and weakness in back and extremities.