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Ann Rehabil Med > Volume 37(4); 2013 > Article
Yi, Shim, Kim, Baek, Jung, Kim, and Han: Prevalence of the Rotator Cuff Tear Increases With Weakness in Hemiplegic Shoulder

Abstract

Objective

To investigate the relationship between the rotator cuff tear (RCT) and the muscle strength in hemiplegic side, and the effects of paralysis on the affected shoulders in hemiplegic patients.

Methods

A cross-sectional observational study performed in a university hospital was presented. The study enrolled 55 participants with hemiplegia of diverse degree of motor paresis, excluding those with bilateral lesions, history of major trauma or other co-existing musculoskeletal disorders of the shoulder. The main outcome measurements were muscle strength of the affected upper extremity (based on Medical Research Council scale), RCTs of the bilateral shoulders (by ultrasonography), and presence of shoulder pain, subluxation of the glenohumeral joint, passive range of motions, and subacromial spurs.

Results

Comparing each side of the shoulders, the prevalence of shoulder pain and supraspinatus muscle tear was higher (p<0.0001, p=0.007), and the range of motion was restricted (p<0.0001, p<0.0001, p<0.0001, p<0.0001) in the affected side. There was a significant trend toward higher prevalence of RCT and shoulder subluxation in the weaker shoulder (p=0.019, p<0.0001). In a multivariate analysis, Manual Muscle Test grade of less than three was an independent risk factor for RCT (p=0.025).

Conclusion

RCT in hemiplegia had a linear trend with muscle weakness in the affected side and the degree of weakness was an independent risk factor for the occurrence of RCT. In addition, shoulder pain, limitation of range of motions, and RCT were more frequent on the hemiplegic side of the shoulders. It is the first study to reveal a linear trend between RCT and upper extremity weakness and will provide physicians an insight to the management of RCTs in hemiplegic patients.

INTRODUCTION

Hemiplegic shoulder pain (HSP) is one of the most common problems after stroke [1-3]. HSP impedes rehabilitation and adversely affects the functional gain [4-7]. Despite the high prevalence and clinical importance, literatures regarding HSP reported conflicting findings regarding the incidence, risk factors, etiology, and treatments. Such discordance partly stems from the differences in the definition of HSP, population characteristics, or the timing of examination among the studies. Thus far, several factors have been proposed as causes of HSP: adhesive capsulitis, complex regional pain syndrome, rotator cuff tear (RCT), joint subluxation, spasticity, and others [7-11].
Among them, RCTs have claimed attention as a considerable portion of the cause of HSP [8,12]. However, there is a controversy over their causal relationship between RCT and hemiplegia. Some studies observed an increased prevalence of RCTs in hemiplegic shoulders compared to the contralateral one or normal control [12,13], and indicated that HSP from RCTs could be markedly reduced by injecting local anesthetics injection into the subacromial space based on the postulate in which the cuff tendons being impinged against the acromion in hemiplegic shoulders [8]. In contrast, other studies found no difference in the incidence of RCT between the affected and unaffected sides, or between hemiplegic and control groups [7,9,10]. Hakuno et al. [9] reported that RCT in hemiplegia were associated with premorbid shoulder pain, not with HSP. The disagreement among studies confuses physicians with the clinical significance of RCT in hemiplegia and treatment of HSP.
Various factors are attributed to the pathogenesis of RCTs, in the general condition. The causative factors of RCT can be divided into the extrinsic and intrinsic ones [14]. Extrinsic factors include anatomical variances, such as the shape of the acromion [15-17], intense mechanical activities or traumatic injuries [18-20]. Intrinsic factors primarily refer to degeneration from aging or repetitive microtrauma [21,22], histologic properties, such as hypovascularity [23-25], biochemical or biomechanical milieu [26] or oxidative stresses [27-29]. If RCTs do develop in hemiplegic shoulders, either intrinsic or extrinsic factors can be suspected to elicit RCTs. For instance, hemiplegic patients may experience alteration of biomechanical or biochemical properties of the rotator cuffs, or they may also be vulnerable to external trauma without appropriate protection by active movement. At any case, motor weakness in hemiplegia can be presumed, with logical plausibility, to be in relation to RCTs.
Therefore, the present study was conducted to investigate the relationship between the RCT and the motor weakness of hemiplegia, and other effects of the paralysis on the affected shoulders in hemiplegic patients.

MATERIALS AND METHODS

Participants

We recruited study participants from the tertiary referral, university hospital in a metropolitan between April 2007 and March 2009. Eligible participants were patients with HSP secondary to strokes or other brain lesions. Hemiplegia was diagnosed when they developed unilateral weakness of sudden onset, which was compatible with brain lesions confirmed by imaging studies, such as magnetic resonance image or computed tomography of the brain. Patients were excluded if 1) weakness was bilateral, 2) any history of intensive trauma of the shoulder was reported, or 3) known musculoskeletal problems of the shoulder preexisted.
The study protocol was approved by the Institutional Review Board of the hospital and all participants gave informed consent.

Outcome measurement

The patients' demographic data, regarding sex, age, height, weight, duration of hemiplegia, presence of diabetes, hemiplegic side, and profiles of the brain lesion were collected. All the participants were asked whether they have pain on either side of their shoulder.

Muscle strength

Physicians evaluated muscle strength of the upper extremity by Manual Muscle Test (MMT), following the Medical Research Council scale. The strength of elbow flexion, with the forearm in supination, represented the upper extremity strength in this study; although shoulder abduction might be more appropriate to indicate proximal strength of the upper extremity, it was not adopted with the concern of the influence by rotator cuff disorders.

Range of motions

Passive range of motions (ROMs) was measured with goniometer, while the patient sitting on a stool. Abduction, forward flexion and external rotation were measured, with the subject asked to relax as much as possible, and the examiner pressing down on the clavicle and scapula with one hand.

Subluxation on physical examination

The subluxation of the glenohumeral joint was examined by palpating the subacromial regions of the both sides and compared the affected side with the unaffected side, while patients were seated and relaxed. When palpated space between the acromion and the humeral head was wider than the unaffected side by one half finger breadth or more, it was judged to be the subluxation.

Radiologic findings

For subjects who had a shoulder X-rays on the day of the examination, the official records of the X-rays were reviewed for checking the presence of subluxations or subacromial spurs on the affected shoulders.

Sonographic findings

All participants received sonographic evaluations of the both, affected and unaffected, shoulders (Accuvix V20; Medison, Seoul, Korea). Ultrasonography routinely checked whether the shoulder contains long biceps tendon sheath swelling, rotator cuff tear, or acromioclavicular joint degeneration.

Statistical analysis

The demographic variables (sex, age, height, weight, duration of hemiplegia, diabetes, and profiles of the brain lesions) and clinical parameters (shoulder subluxation, subacromial spur, and shoulder pain) were compared among the five groups divided by the upper extremity motor power. Since the sample size was not large enough to guarantee normal distribution, Pearson χ2 or Fisher exact tests and Kruskal-Wallis tests were used. The information about the shoulder on the affected and unaffected side was compared between them, using McNemar and Wilcoxon signed-rank tests. A linear-by-linear association was used to compare the ordinal variables, as needed. To determine the independent risk factors for RCT, a multiple regression analysis with logistic model was used to control for the effects of confounding variables. The significance level was determined at 5%, and all statistical analyses were performed using SPSS software (SPSS Inc., Chicago, IL, USA).

RESULTS

Demographic and clinical parameters

Among the included 55 patients, twenty-eight patients (51%) were male sex, and the mean age was 63.5 years old. Thirty-eight patients (69%) had infarction, fifteen (27%) had hemorrhage, and two (4%) had tumor for the etiology of the hemiplegia. The duration from the hemiplegia onset to the examination was 54.0 days (range, 6-197 days). Sixteen patients (29%) had hemiplegia on the right side and twenty patients (36%) had diabetes.
Eleven, 14, 9, 11, and 10 patients presented upper extremity muscle power of MMT grade 0, 1, 2, 3, and 4 (Table 1). All the demographic variables were comparable among the five groups. The prevalence of subacromial spur and shoulder pain on each side showed no statistical differences as well. However, shoulder subluxation was statistically different among those groups (p<0.001 for subluxations on physical exams, p=0.003 for those on the X-rays).

Effect of hemiplegia on the shoulder

The affected and unaffected shoulders of 55 hemiplegia patients were compared between them (Table 2). The prevalence of shoulder pain and supraspinatus muscle tear were significantly different between the two groups (p<0.001 and p=0.007, respectively). ROMs to all directions-abduction, forward flexion, external rotation, and internal rotation-also presented statistical differences between the two groups (p<0.001, p<0.001, p<0.001, p<0.001, respectively).

Muscle strength and rotator cuff tear

RCTs and shoulder subluxations according to the upper extremity muscle strength were shown (Fig. 1). A significant trend toward higher prevalence of RCT and shoulder subluxation in weaker motor power was demonstrated using a linear-by-linear association (p=0.019 and p<0.001, respectively).
A multivariate analysis with logistic regression model for RCTs adjusting sex, age, duration of hemiplegia, hemiplegic side, diabetes, and motor function of the upper extremity-MMT grade weaker than three-was also demonstrated (Table 3). Upper extremity muscle strength weaker than grade three was identified as an independent risk factor for RCT (p=0.025, odds ratio=4.23).

DISCUSSION

The purpose of this study was to investigate the relationship between the RCT and muscle strength in the hemiplegic side, and the effects of the paralysis on the affected shoulders in hemiplegic patients. It was demonstrated that hemiplegic shoulder have higher prevalence of shoulder pain, supraspinatus tear, and limited ROMs. A significant trend toward higher prevalence of RCT and shoulder subluxation in weaker upper extremity motor power was observed, and the muscle strength was identified as an independent predisposing factor for the RCT.
The results of the current study correspond with the previous studies that demonstrated increased prevalence of the RCT in hemiplegia [8,12,13], but disagree with other reports that suggested no association between them [7,9,10]. However, our results may explain the existing disagreement among the previous studies. The observation that the occurrence of RCT in hemiplegia was dependent on the severity of motor weakness suggests that the association of RCT with hemiplegia can be altered, according to the distribution of motor paresis within the study populations. That is, studies that recruited patients of milder paresis would document equivocal association between RCT and hemiplegia [7,11], while studies with participants of more severe paresis would reveal a significant association between them [9,13].
Our results suggest several explanations on how RCT can develop in hemiplegic shoulders. First, increased tension on the rotator cuff tendon might induce its biomechanical failure. According to the experiments about mechanical properties of the glenohumeral joint, the supraspinatus tendon was reported as the strongest static stabilizer against inferior translation of the humerus [30,31]. However, in the circumstances where the dynamic stabilizers, such as deltoid and other shoulder girdle muscles, fail to sustain the downward force of the gravity, just as in hemiplegia, the supraspinatus tendon is inevitably exposed to the increased tensile load [30,32]. The weaker the muscle strength, the more tension is imposed on the supraspinatus tendon. Although the tendon would maintain its integrity within the tolerable range of stress-strain relationship, a prolonged tensile overload may cause mechanical fatigue, loss of elasticity and eventually the tear of the tendon. That scheme is substantiated by the observation that most RCTs of the hemiplegic shoulder involved the articular side of the supraspinatus; 28 tears out of 33 were on the articular side and 30 tears were in the supraspinatus tendon. It is worth to note that the articular side of the tendon can endure less tension and less deformation than the bursal side [26]. Second, paretic shoulder girdle muscles may predispose rotator cuff tendons to repetitive trauma. Altered kinetics of the shoulder in hemiplegia might provoke impingement at the subacromial space [33,34] or there may be iatrogenic soft tissue injuries caused by passive mobilization of the shoulder during a routine physiotherapy for rehabilitation [35,36]. In such cases, the absence of protective, coordinated movement by active contraction would probably aggravate the rotator cuff tendinopathy.
In this study, shoulder subluxation also had a trend according to the muscle strength on the hemiplegic side. It was significantly different among the five groups divided by motor power as well. There is a possibility that the presence of shoulder subluxation in weaker upper extremity strength might predispose or precipitate RCTs. On the contrary, another possibility that apparent RCTs in weaker shoulder might entail the subluxation is also present. These possibilities cannot be differentiated in this study. However, it can hardly be contradicted that the weakness is a preceding condition for the subluxation, and thus, the current study was focused on the occurrence of RCT in relation to the severity of paresis.
Meanwhile, not only supraspinatus tear, but also shoulder pain and limitation of ROM were more common in the affected side. However, there was no trend between the motor power of affected shoulder and shoulder pain or limitation of ROMs. Other previous studies did not reveal a definite relationship of RCT to HSP [9,37], either, suggesting that RCT may not be the main pathology of HSP. In addition, most degenerative RCTs were known to be asymptomatic [1] in the aged population; the RCT in hemiplegic shoulder might be pathophysiologically analogous to asymptomatic degenerative RCTs. Therefore, the results of higher prevalence of pain and limitation of ROM in the affected shoulder might be coincidental findings, which may be present in the hemiplegic shoulders.
This is the first study that demonstrated a difference of the prevalence of RCT among the different upper extremity muscle strength groups. The results presented a strong trend toward higher prevalence of RCT in weaker upper extremities, and pointed out that the motor function of the affected side may be the independent predisposing factor for the RCTs.
On the other hand, the prevalence of RCT in this study was up to 55% and was much higher than the previous cadaveric study result of 30% [1]. However, the current study included patients with HSP, in contrast to the cadaveric study, which recruited both symptomatic and asymptomatic subjects. Further, the observed prevalence was similar with the previously reported prevalence of RCT in HSP, 50% [11] and 40% [38].
There are a few limitations to be considered in our study. Most of all, since the subject collection was not randomized, the study population may not represent crude hemiplegic patients. Second, the study was designed as a cross-sectional study. Thus, the association between weakness and RCTs cannot necessarily indicate their causal relationship. Third, the sample size was not large enough to evaluate the associations of various clinical parameters with RCT or HSP. The sample size was calculated to test the association between hemiplegia and RCT, and the correlation of RCT with muscle weakness; other hypotheses were not included in the design of the study. Lastly, we measured elbow flexion to evaluate the upper extremity motor power to prevent shoulder pain from interfering with shoulder motor power measurement. However shoulder abductor or flexor power would have a more close relationship with the mechanism of RCTs. Further study with larger sample size and longitudinal follow-up may confirm the causality between the hemiplegia and RCT or evaluate other possible relationship among the other factors.
In conclusion, RCT in hemiplegia had a linear trend with muscle weakness in the affected side and the weakness might be the independent risk factor for the occurrence of RCT. In addition, shoulder pain, limitation of ROMs, and RCT were more frequent on the hemiplegic of shoulders. It is the first study to reveal a linear trend between RCT and weakness of the hemiplegia, and will provide physicians an insight to the management of RCTs in hemiplegic patients. Further research with longitudinal follow-up may provide more information regarding the mechanism of RCT.

CONFLICTS OF INTEREST

No potential conflict of interest relevant to this article was reported.

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Fig. 1
Rotator cuff tears and shoulder subluxations according to the motor function. A trend toward higher prevalence of rotator cuff tear and shoulder subluxation in weaker upper extremities was demonstrated (p=0.019 and p<0.001, respectively; using linear-by-linear association).
arm-37-471-g001.jpg
Table 1
Demographic and clinical variables of the participants
arm-37-471-i001.jpg

Values are presented as number (%) or mean±standard deviation.

a)p<0.01.

Table 2
Effect of hemiplegia on the shoulder
arm-37-471-i002.jpg

Values are presented as number (%) or mean±standard deviation.

LBT, long biceps tendon; AC, acromioclavicular.

a)p<0.01.

Table 3
Multivariate analysis with logistic regression model for rotator cuff tears
arm-37-471-i003.jpg

OR, odds ratio; CI, confidence interval; MMT Gr, Manual Muscle Test grade.

a)p<0.05.

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