Diabetic muscle infarction (DMI) is an unusual neuromuscular complication of diabetes mellitus. It tends to occur in young, poorly controlled, insulin dependent diabetic patient with end-organ complication. We report a 24-year-old woman with diabetic muscle infarction in both lower extremities. DMI began with an abrupt onset of pain, tenderness, swelling and formation of a firm mass. MRI revealed an increase in the signal intensity on T2 weighted image and SPECT showed an increased uptake of Tc-99m-pyrophosphate (PYP) in affected muscles. We report this case with review of the literature.