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Journal of the Korean Academy of Rehabilitation Medicine 2000;24(1):100-107.
The Significance of Anti-type I Collagen Antibody Titer in Occupational Low Back Pain.
Lee, Jongmin , Kwon, Yong Wook , Kim, Soo Keun , Lim, Hyun Sul , Kim, Ji Yong , Chung, Junho
1Department of Rehabilitation Medicine, Dongguk University College of Medicine.
2Department of Preventive Medicine, Dongguk University College of Medicine.
3Department of Biochemistry, Dongguk University College of Medicine.
직업성 요통 환자에서 항 제 I 형 교원질 항체역가의 의의
이종민, 권용욱, 김수근1, 임현술1, 김지용1, 정준호2
동국대학교 의과대학 재활의학교실, 1예방의학교실, 2생화학교실
Abstract

Objective
To assess the significance of anti-type I collagen antibody titer in estimating cumulative trauma and predicting the presence of occupational low back pain.


Method
Under the hypothesis that cumulative trauma on the spine will expose collagen and stimulate the formation of auto-antibody, we measured the serum anti-type I collagen antibody titers (IgM and IgG) in 408 male workers of a metal welding and manufacturing company. The antibody titers were measured in duplicates by ELISA. Statistical analysis was done to compare the titers according to occupational profiles (type of occupation and duration of employment) and clinical profiles (occurrence of low back pain, duration of low back pain and clinical impression).


Results
The anti-type I collagen IgG antibody titers were significantly increased in labor workers (n=357) in comparison with office workers (n=51)(p<0.05). Among the labor workers both IgM and IgG antibody titers were increased in the low back pain group (n=50) though it did not reach statistical significance (p-value of IgM antibody titers=0.07). IgM and IgG antibody titers were increased in the chronic low back pain group (≥3 months)(n=8).


Conclusion
These data suggest that anti-type I collagen IgM and IgG antibody may be useful in predicting the presence of occupational low back pain and estimating cumulative trauma, respectively.

Key Words: Anti-type I collagen antibody, Occupational low back pain, Cumulative trauma


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