Objective: To determine whether estradiol (E2), lipid profile, biochemical markers, and bone mineral density (BMD) are related according to postmenopausal period.
Method: One hundred fifty four women were divided into four groups according to the time past menopause: group I (0∼5 years), group II (6∼10 years), group III (11∼15 years), group IV (more than 16 years). Group I, II, III were subdivided into osteoporosis group (t-score＜2.5) and non-osteoporosis group (t-score≥2.5). E2, lipid profile, osteocalcin, alkaline phosphatase, deoxypyridinoline, and BMD by DEXA were measured in all groups.
Results: There were significant inverse correlation between BMD and postmenopausal period (p＜0.05). Deoxypyridinoline and osteocalcin were correlated with postmenopausal period but there was no statistical significance. Deoxypyridinoline and osteocalcin were increased in osteoporosis group compared to non-osteoporosis group but there was no statistical significance. E2 had significant inverse correlations with postmenopausal period (p＜0.05). E2 had no correlation with factors such as biochemical markers and lipid profile in group I, II, III but had adverse correlation with deoxypyridinoline in group IV.
Conclusion: No specific biochemical markers regarding the duration of menopause were found. Regardless of the duration of menopause, checking both osteocalcin and deoxypyridinoline was statistically significant for the evaluation of postmenopausal osteoporosis.
