J Korean Acad Rehabil Med Search


Journal of the Korean Academy of Rehabilitation Medicine 2000;24(4):611-627.
Effects of Methylphenidate on Cognitive Impairment Following Brain Injury: A double-blind placebo-controlled study.
Kim, Yun Hee , Na, Seung Yong , Shin, Yong Il , Seo, Jeong Hwan
Department of Rehabilitation Medicine, Chonbuk National University College of Medicine.
뇌손상 후 인지기능장애에 대한 메칠페니데이트의 효과 ⁣이중맹검 위약대조 연구⁣
김연희, 나승용, 신용일, 서정환
전북대학교 의과대학 재활의학교실

To evaluate the effect of methylphenidate on cognitive function especially on working memory and visuospatial attention in the patients with traumatic brain injury (TBI).

Eighteen subjects, 16 males and 2 females, with TBI were enrolled. Their mean age was 34.2 years old. A double-blind placebo-controlled study was designed. The baseline cognitive assessment was performed before the administration of drug. Two days after the baseline study, 20 mg of methylphenidate or placebo was administered. The second cognitive assessment was performed 2 hours after the treatment. The follow-up assessment conducted two days after the second test. Cognitive assessments consisted of 'one-back working memory task' and 'endogenous visuospatial attention task', designed using SuperLab Pro 2.0 software.

In one-back working memory test, there was significant improvement of response accuracy in methylphenidate group in comparison with placebo group (p<0.01). Significant shortening of reaction time was also seen after the administration of drug in methylphenidate group (p<0.05). In endogenous visuospatial attention test, significant improvement of response accuracy was noticed after the administration of drug in methylphenidate group (p<0.05).

These results demonstrated that the administration of methylphenidate was beneficial in improving cognitive function following TBI. The effect was prominent in the accuracy of working memory.

Key Words: Working memory, Methylphenidate, Traumatic brain injury, Working memory, Visuospatial attention


Browse all articles >

Terms of Use   |   Privacy Polity
Editorial Office
Department of Rehabilitation Medicine, Seoul National University Hospital
101 Daehak-ro, Jongno-gu, Seoul, Korea
Tel: +82-10-8678-2671    Fax: +82-2-6072-5244    E-mail: edit@e-arm.org; edit.karm@gmail.com
Business Registration: 110-82-07460                

Copyright © 2024 by Korean Academy of Rehabilitation Medicine.

Developed in M2PI

Close layer