J Korean Acad Rehabil Med Search

CLOSE


Journal of the Korean Academy of Rehabilitation Medicine 2001;25(3):486-490.
The Relations between Bone Density and Plasma Leptin in Postmenopausal Women.
Choi, Eun
Department of Rehabilitation Medicine, Soonchunhyang University College of Medicine.
폐경 후 여성에서 골밀도와 혈중 Leptin치의 관계
최은
순천향대학교 의과대학 재활의학교실
Abstract

Objective
To investigate the relationship between the plasma leptin concentration and bone metabolism in postmenopausal women with osteoporosis to improve the understanding of the role of leptin in controlling bone mass.


Method
Fifty four postmenopausal women (ages 64⁑8.59 years, body weights 58.14⁑6.92 kg) with osteoporosis were included. The biochemical markers of bone metabolism and serum leptin concentration were measured using the radioimmunoassay. Bone mineral densities were measured by dual energy X-ray absorptiometry. And we investigate the correlation between serum leptin concentration and the biochemical markers of bone metabolism or bone mineral density.


Results
The bone mineral densities were 0.639⁑0.130 g/cm2 in mid-lumbar area, 0.684⁑0.098 g/cm2 in femoral neck and 0.491⁑0.117 g/cm2 in Ward's triangle. The mean value of serum osteocalcin was 26.84⁑16.73 ng/ml, the mean value of urine deoxypyridinoline was 11.84⁑6.08 nmol/mmol Cr, and the plasma concentration of leptin was 11.51⁑8.64 ng/ml. There was no correlation between plasma leptin concentrations and the markers of bone metabolism or bone mineral density.


Conclusion
We could not confirm the significant correlation between the circulating leptin concentration and the bone mass in postmenopausal women. Our data suggest circulating plasma leptin does not have a significant direct influence on bone metabolism and bone mass in postmenopausal women.

Key Words: Plasma leptin, Bone mineral density, Menopause


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Terms of Use   |   Privacy Polity
Editorial Office
Department of Rehabilitation Medicine, Seoul National University Boramae Medical Center,
20 Boramae-ro 5-gil, Dongjak-gu, Seoul, 07061, Korea
Tel: +82-2-870-2679    Fax: +82-2-870-2679    E-mail: edit@e-arm.org
Business Registration: 110-82-07460                

Copyright © 2019 by Korean Academy of Rehabilitation Medicine. All rights reserved.

Developed in M2community

Close layer
prev next