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Journal of the Korean Academy of Rehabilitation Medicine 2003;27(6):922-927.
The Effect of Sub-threshold 1 Hz and 20 Hz Repetitive Transcranial Magnetic Stimulation on Corticospinal Excitability.
Yoo, Woo Kyoung , Chung, Gwang Ik , Lee, Ju Hyung , Choi, Eun Hee , Jun, Ah Young , Kim, Jong chul , Ahn, Hyo Je
Department of Rehabilitation Medicine, Hallym University College of Medicine, Korea. okbomb@lycos.co.kr
1 Hz와 20 Hz 역치하 반복경두부자기자극에 의한 대뇌피질 흥분도 변화
유우경, 정광익, 이주형, 최은희, 전아영, 김종철, 안효제
한림대학교 의과대학 재활의학교실
Abstract
Objective
This explored whether the effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on corticospinal excitability are dependent on the stimulation frequency.


Method
Ten subjects were investigated using either 20 Hz or 1 Hz rTMS. To reduce inter-individual variability, we explored same subject in one week interval with different frequency. TMS was conducted with intensity of 90% of motor threshold. The effect of rTMS with EMG amplitude evoked in First Dorsal Interossei by TMS. Test motor evoked potentials were evaluated with intensity of 110% of motor threshold before rTMS, during the interval and immediately, 5 minutes, 20 minutes after the end of train.


Results
The analysis showed a significant decrease of cortical excitability after 1 Hz rTMS and an increase after 20 Hz rTMS. In low-frequency, Motor Evoked Potential (MEP) amplitude decreased quickly after initial 300 pulses stimulation. In high-frequency, there were some variation of individual MEP in the response to rTMS. The changes of MEP amplitude after 1200 stimulation continued until 20 minutes.


Conclusion
These results provided basic evidence of rTMS for modulation of cortical excitability and could be further applied in patients group. (J Korean Acad Rehab Med 2003; 27: 922-927)

Key Words: Repetitive transcranial magnetic stimulation, Motor cortex


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