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Journal of the Korean Academy of Rehabilitation Medicine 2004;28(4):301-305.
Central Neural Networks of Verbal Working Memory and Visuospatial Attention: An Interference Approach Using Low-frequency Repetitive Transcranial Magnetic Stimulation.
Ko, Myoung Hwan , Seo, Jeong Hwan , Jang, Sung Ho , Yoo, Woo Kyoug , Kim, Yun Hee
1Department of Physical Medicine and Rehabilitation, Chonbuk National University Medical School, Research Institute of Clinical Medicine, Korea.
2Department of Physical Medicine and Rehabilitation, School of Medicine, Yeungnam University, Korea.
3Department of Rehabilitation, Hallym University College of Medicine, Korea.
4Department of Physical Medicine and Rehabilitation, Samsung Medical Center & Center for Clinical Medicine, SBRI, Sungkyunkwan University School of Medicine, Korea. yunkim@smc.samsung.co.kr
반복 경두개자기자극을 이용한 작업기억 및 시공간 주의력 뇌 신경망 연구
고명환, 서정환, 장성호1, 유우경2, 김연희3
전북대학교 의과대학 재활의학교실 및 임상의학연구소, 1영남대학교 의과대학 재활의학교실, 2한림대학교 의과대학 재활의학교실, 3성균관대학교 의과대학 삼성서울병원 재활의학과 및 임상의학연구센터
We evaluated a role of prefrontal and parietal cortex in verbal working memory and visuospatial attention using repetitive transcranial magnetic stimulation (rTMS).
In six healthy volunteers, bilateral prefrontal and parietal cortex was stimulated with rTMS (90% of motor threshold, 10 trains of 1 Hz rTMS) during performed cognitive tasks (two-back verbal working memory task and endogenous visuospatial attention task). rTMS was applied to 4 different sites over left prefrontal, right prefrontal, left parietal and right parietal areas at F3, F4, P3 and P4 location on the scalp, according to the 10/20 EEG system. The sham stimulation was applied with the coil placed perpendicular to the scalp.
Reaction time (RT) was significantly prolonged by left prefrontal TMS in verbal working memory. In addition, performance deterioration was also observed during rTMS over the right prefrontal and left parietal areas. In visuospatial attention task, RT was significantly prolonged by right parietal TMS.
These results show that left prefrontal cortex play a major role in the network of working memory, and right parietal cortex is important area in the visuospatial attention. We suggest that an rTMS could be a useful method for evaluation of neural network in human brain. (J Korean Acad Rehab Med 2004; 28: 301-305)
Key Words: Repetitive transcranial magnetic stimulation, Working memory, Visuospatial attention, Cognition


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