| The Effect of Intrathecal Baclofen Injection on Muscle Stretch Reflex in Spinal Cord Injured Rabbit. |
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Woo, Young Tae , Sung, Duk Hyun , Lee, Yang Gyun , Jung, June Yong , Jeong, Soon Tak , Park, Sung Min , Choi, Young Kwon |
1Department of Physical Medicine and Rehabilitation, Samsung Medical Center, Sungkyunkwan University College of Medicine, Korea. dhsung@smc.samsung.co.kr
2Department of Physical Medicine and Rehabilitation, Soonchunhyang University College of Medicine, Korea.
3Department Physical Medicine and Rehabilitation, National Cancer Center, Korea. |
| 척수 손상 토끼의 근 신장 반사에서 척수강내 바클로펜 주입법의 효과 |
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우영태, 성덕현, 이양균1, 정준용2, 정순탁, 박성민, 최영권 |
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성균관대학교 의과대학 삼성서울병원 재활의학교실, 1순천향대학교 의과대학 재활의학교실, 2국립암센터 재활의학과 |
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| Abstract |
Objective
To develop an experimental model that is useful to evaluate the effect of antispastic medication administered intrathecally and to titrate the intrathecal baclofen effect quantitatively by using muscle stretch reflex.
Method
Ten rabbits were laminectomized posteriorly and intrathecal catheter was inserted. Then the spinal cords were contused by 12.5 g⁓20 cm weight drop around 12th thoracic vertebra. After 8∼12 days, muscle stretch reflex was measured before intrathecal baclofen injection (ITBI) and after ITBI 30 minutes, 60 minutes, and 120 minutes. Rabbits' triceps surae were dissected and stretched 5 mm at the rate of 2 mm/sec using a step motor. The change of muscle tension was graphed into the time (length)-tensioncurve. The slope in the time (length)-tension curve was defined as stiffness index (SI).
Results
The measurement of muscle stretch reflex was available in 5 of 10 spinal cord injured rabbits. The proportion of SI reduced significantly at 60 minutes and 120 minutes compared to baseline (p=0.005, p＜0.001).
Conclusion
Our data proved the antispastic effect of ITBI quantitatively by using muscle stretch reflex. We concluded that the quantitative measurement method of the antispastic effect of ITBI will be useful in evaluating antispastic effect by intrathecal administration of the other antispastic medications. (J Korean Acad Rehab Med 2004; 28: 311-318) |
| Key Words:
Spasticity, Spinal cord injury, Stretch reflex, Stiffness index, Intrathecal baclofen |
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