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Journal of the Korean Academy of Rehabilitation Medicine 2005;29(1):87-91.
The Change of Serum and Synovial IGF-I Level in Patients with Knee Osteoarthritis.
Kim, Sang Beom , Park, Sang Hyun , Yoon, Kisung , Lee, Kyeong Woo , Hyun, Kwak , Park, Kyung A
Department of Physical Medicine and Rehabilitation Medicine, Dong-A University College of Medicine, Korea. ufsmfx@hanmail.net
퇴행성 슬관절염 환자에서 혈청 및 활액 IGF-1의 변화
김상범, 박상현, 윤기성, 이경우, 곽현, 박경아
동아대학교 의과대학 재활의학교실
Abstract
Objective
The purpose of this study was to investigate the serum and synovial IGF-I levels in 30 patients with knee osteoarthritis (OA) and the relationships among the IGF-I level, pain intensity and severity of knee OA.
Method
Thirty patients who met criteria of knee OA of American Rheumatology Association participated in this study. Samples of serum and synovial fluid were obtained from all patients. The levels of IGF-I were determined by radioimmunoassay (RIA). The intensity of pain was assessed by Pain Rating Score (PRS) and Visual Analogue Scale (VAS). The severity of knee OA was evaluated by Kellgren's grade of knee OA.
Results
The mean serum and synovial IGF-I level was 231.66±86.15 ng/ml and 122.42±37.79 ng/ml, respectively. There was no correlation between pain intensity and IGF-I levels. Neither was there statistically significant correlation between Kellgren's grade and IGF-I levels.
Conclusion
The serum and synovial IGF-I levels were not related with pain intensity and severity of knee OA. (J Korean Acad Rehab Med 2005; 29: 87-91)
Key Words: Knee osteoarthritis, IGF-I


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