The Effect of Isoflavone on Bone Mineral Density and Maximum Load in Stroke Rat.

, Won, Sun Jae; , Ko, Young Jin; , Kim, Jong Hyun; , Kim, Hye Won; , Lim, Ji Eun; , Jeung, In Suek; , Lee, Jong In

Original Article

Journal of the Korean Academy of Rehabilitation Medicine 2005;29(6):635-639.

Won, Sun Jae , Ko, Young Jin , Kim, Jong Hyun , Kim, Hye Won , Lim, Ji Eun , Jeung, In Suek , Lee, Jong In

Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Korea. ljikyh@catholic.ac.kr

뇌경색 백서에서 이소플라본이 골밀도 및 최대부하에 미치는 영향

원선재, 고영진, 김종현, 김혜원, 임지은, 정인숙, 이종인

가톨릭대학교 의과대학 재활의학교실

Abstract

Objective
Because bone metabolic changes progress from initial stage of stoke, early prevention and treatment have been important. Isoflavone has been proved to be effective in post-menopausal osteoporosis. Therefore the authors used a stroke rat model and evaluated the effects of isoflavone on bone metabolism from initial stage of stroke.
Method
Female Sprague-Dawley rats were randomly divided into 2 separate groups; a stroke without isoflavone supplement group and stroke with isoflavone supplement group. The bone mineral density (BMD) in 4th and 5th lumbar vertebrae were measured at the day before stroke, 11th and 18th days after the stroke. The BMD in excised distal femur and proximal tibia and the maximum load offemur neck and tibia shaft were measured at 18th days after the stroke.
Results
On the 18th day after stroke, BMD of stroke with isoflavone group was significantly higher than that of stroke without isoflavone group in 4th and 5th lumbar vertebrae and distal femur. The maximum load of stroke with isoflavone group was significantly higher than that of stroke without isoflavone group in femur neck.
Conclusion
The results suggested that isoflavone supplement in stroke rat had beneficial effect on bone metabolism from the initial stage of stroke. (J Korean Acad Rehab Med 2005; 29: 635-639)

Key Words: Isoflavone, Osteoporosis, Stroke, Bone mineral density, Maximum load