Clinical Features of Central Neuropathic Pain after Contusive Spinal Cord Injury in Rats.

, Lee, So Young; , Im, Hyeong Lyong; , Kim, Jae Hyung; , Jung, Sung Hwan; , Choi, In Sung; , Lee, Sam Gyu

Original Article

Journal of the Korean Academy of Rehabilitation Medicine 2006;30(2):142-147.

Lee, So Young , Im, Hyeong Lyong , Kim, Jae Hyung , Jung, Sung Hwan , Choi, In Sung , Lee, Sam Gyu

¹Department of Physical Medicine & Rehabilitation, Chonnam National University Medical School, Korea. sam91@chonnam.ac.kr
²Chonnam National University Hwasun Hospital, Korea.

척수좌상 백서모델에서 중추 신경병증성 통증의 발현양상

이소영¹, 임형룡, 김재형¹, 정성환, 최인성, 이삼규

전남대학교 의과대학 재활의학교실, ¹화순전남대학교병원 재활의학과

Abstract

Objective
To investigate the characteristics of the central neuropathic pain (CNP) after contusive spinal cord injury in rats.
Method
Twenty Sprague-Dawley rats (300⁑50 g, male) undergone the free-drop contusion injury from the drop- height of 2.5 cm at T10 cord (n=20) and ten rats undergone sham operation (n=10) were subjected to the neurobehavioral analyses by the Basso Beattie Bresnahan (BBB) locomotor rating scales, Touch test^TMsensory evaluator (TTSE, North Coast Medical Inc., Canada) and Plantar test^Ⱂ (Ugo Basile, Italy) after contusion at the 1^st, 3^rd, 5^th, 7^th, 14^th, 21^st and 28^th day.
Results
The scores of BBB scales were the lowest at the1^st day and then slowly increased to spontaneous recovery state, but they were significantly lower than those of control group (p＜0.05). The thresholds of mechanical allodynia were significantly increased just after cord contusion, but progressed to decline, and significantly decreased after the 21^st day (p＜0.05). The latencies of thermal hyperalgesia were delayed just after cord contusion, but significantly shorter than those of the control group after the 7^th day (p＜0.05).
Conclusion
These results would be helpful for the study of the CNP after contusive spinal cord injury in rats. (J Korean Acad Rehab Med 2006; 30: 142-147)

Key Words: Central neuropathic pain, Spnal cord injury, Mechanical allodynia, Thermal hyperalgesia