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Journal of the Korean Academy of Rehabilitation Medicine 2006;30(2):142-147.
Clinical Features of Central Neuropathic Pain after Contusive Spinal Cord Injury in Rats.
Lee, So Young , Im, Hyeong Lyong , Kim, Jae Hyung , Jung, Sung Hwan , Choi, In Sung , Lee, Sam Gyu
1Department of Physical Medicine & Rehabilitation, Chonnam National University Medical School, Korea. sam91@chonnam.ac.kr
2Chonnam National University Hwasun Hospital, Korea.
척수좌상 백서모델에서 중추 신경병증성 통증의 발현양상
이소영1, 임형룡, 김재형1, 정성환, 최인성, 이삼규
전남대학교 의과대학 재활의학교실, 1화순전남대학교병원 재활의학과
To investigate the characteristics of the central neuropathic pain (CNP) after contusive spinal cord injury in rats.
Twenty Sprague-Dawley rats (300⁑50 g, male) undergone the free-drop contusion injury from the drop- height of 2.5 cm at T10 cord (n=20) and ten rats undergone sham operation (n=10) were subjected to the neurobehavioral analyses by the Basso Beattie Bresnahan (BBB) locomotor rating scales, Touch testTM sensory evaluator (TTSE, North Coast Medical Inc., Canada) and Plantar test (Ugo Basile, Italy) after contusion at the 1st, 3rd, 5th, 7th, 14th, 21st and 28th day.
The scores of BBB scales were the lowest at the1st day and then slowly increased to spontaneous recovery state, but they were significantly lower than those of control group (p<0.05). The thresholds of mechanical allodynia were significantly increased just after cord contusion, but progressed to decline, and significantly decreased after the 21st day (p<0.05). The latencies of thermal hyperalgesia were delayed just after cord contusion, but significantly shorter than those of the control group after the 7th day (p<0.05).
These results would be helpful for the study of the CNP after contusive spinal cord injury in rats. (J Korean Acad Rehab Med 2006; 30: 142-147)
Key Words: Central neuropathic pain, Spnal cord injury, Mechanical allodynia, Thermal hyperalgesia


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