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Journal of the Korean Academy of Rehabilitation Medicine 2007;31(4):387-393.
The Effect on Fos Expression in Rat Spinal Cord following Stimulation to Dorsal Root Ganglion by Pulsed Radiofrequency.
Seo, Jeong Hwan , Byeon, Whan Taek , Kwon, Young Bae , Sim, Young Joo
1Department of Rehabilitation Medicine, Chonbuk National University Medical School, Korea. oggum@daum.net
2Department of Pharmacology, Chonbuk National University Medical School, Korea.
3Department of Rehabilitation Medicine, Changwon Hospital, Korea.
백서 후근신경절에 박동성 고주파 자극이 척수 내 Fos 발현에 미치는 영향
서정환, 변환택1, 권영배2, 심영주
전북대학교 의과대학 재활의학교실 및 2약리학교실, 1창원 산재병원 재활의학과
Abstract
Objective
To reconfirm the relationship between the Fos expression and the pulsed radiofrequency which very few articles have reported.
Method
Thirty-four male Sprague-Dawely rats were enrolled: 8 for lumbar 3rd dorsal root ganglion (DRG) stimulation, 4 for L3 and L4 DRGs, 5 for C5 and C6 DRGs, 8 for sham L3 DRGs, 5 for sham L3 and L4 DRGs, and 4 for sham C5 and C6 DRGs. Without laminectomy, each lumbar DRG was stimulated with PRF for 2 minutes 2 times with 42°C. Sham group was stimulated with PRF electrode but without any stimulation. Three hours after the stimulations, spinal cord was thin sectioned for immunohistochemistry and Fos expression was calculated. Individual sections were digitized with 4096 gray levels using a computer assisted image analysis system. With laminectomy, cervical DRGs was stimulated with the same method of lumbar DRGs. Sham stimulation was applied to the sham group.
Results
No significant difference of Fos expression was observed on dorsal horn of rat in operated site, 3 hours later after operation, between the PRF and sham group in lumbar DRGs and the PRF and sham groups in cervical DRGs.
Conclusion
The expression of Fos was not significantly related with the cervical and the lumbar DRGs stimulation with PRF. (J Korean Acad Rehab Med 2007; 31: 387-393)
Key Words: Fos, Pulsed radiofrequency, Dorsal root ganglion
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