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Journal of the Korean Academy of Rehabilitation Medicine 2008;32(5):491-500.
Effects of Transplantation of Human Embryonic Stem Cellson Functional Recovery in Spinal Cord Injured Rats.
Jung, Kwang Ik , Park, Chang Il , Park, Eun Sook , Shin, Ji Cheol
1Department of Physical Medicine and Rehabilitation, Hallym University College of Medicine, Korea. jki@hallym.ac.kr
2Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Korea.
척수손상 쥐에서 인간 배아 줄기세포의 이식이 기능적 회복에 미치는 효과
정광익, 박창일1, 박은숙1, 신지철1
한림대학교 의과대학 재활의학교실, 1연세대학교 의과대학 재활의학교실 및 재활의학연구소
Abstract
Objective
To investigate the functional recovery following the transplantation of human embryonic stem (hES) cells into an injured rat spinal cord.
Method
Sprague-Dawley rats were subjected to the spinal cord injury (SCI) using the New York University impactor. The rats were randomly allocated into three groups of 12 rats each, one media-treated and two hES cell-transplanted groups (5×103/5Ռl, 2×104/5Ռl). The hES cells were transplanted 1 week after a SCI.
Results
The hES cells transplanted into the rats were found to promote the hind limb performance 8 weeks after transplantation. In the electrophysiological study, the transplanted rats showed significantly shortened latencies and increased amplitudes of motor and somatosensory evoked potentials, compared to the media-treated rats. In the spinal cord of the hES cell-treated group, the pathological findings including the glial scar formation and degenerative changes were attenuated and the human Tau protein-positive cells were identified in the vicinity of the necrotic cavity and in the white matter.
Conclusion
These results suggest that the transplantation of hES cells might play a role in promoting the functional recovery after a SCI. (J Korean Acad Rehab Med 2008; 32: 491-500)
Key Words: Spinal cord injury, Human embryonic stem cells, Transplantation, Functional recovery


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