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Journal of the Korean Academy of Rehabilitation Medicine 2008;32(6):612-618.
Effects of Functional Magnetic Stimulation on the Functional Recovery in a Rat Model of Spinal Cord Injury.
Park, Hea Woon , Kim, Su Jeong , Seo, Jeong Min , Cho, Yun Woo , Jang, Min Chul , Kim, Dong Kyu , Ahn, Sang Ho
1Department of Rehabilitation Medicine, Daegu Catholic University Medical Center, Korea.
2Institute of Biomedical Engineering, Yeungnam University, Korea.
3Department of Rehabilitation Medicine, College of Medicine, Yeungnam University, Korea. spineahn@yumail.ac.kr
척수손상 모델 흰쥐에서의 기능적 자기자극 치료의 효과
박해운, 김수정1, 서정민1, 조윤우2, 장민철2, 김동규2, 안상호2
대구가톨릭대학병원 재활의학교실, 1영남대학교 의료공학연구소, 2영남대학교 의과대학 재활의학교실
Abstract
Objective
To investigate the effects of functional magnetic stimulation (FMS) on the functional recovery in a rat model of spinal cord injury (SCI).
Method
Forty-five Sprague-Dawley rats (200∼250 grams, female) were used. Rats were laminectomized and the T9 segment of spinal cord was contused using New York University (NYU) spinal impactor. Ten gram weight rod was dropped from a height of 25 mm to produce moderately contused spinal cord injury model. The animals were randomly assigned to 2 groups: one exposed to FMS (FMS group) and the other not exposed to FMS (non-FMS group). Transcranial functional magnetic stimulation was noninvasively applied for 4 weeks. To compare the results between FMS group and non-FMS group, motor functions were evaluated with the Basso, Beattie, and Bresnahan (BBB) locomtor rating scale and inclined plane test, and somatosensory evoked potentials (SEP) and motor evoked potentials (MEP) were also recorded.
Results
There was a significant difference in locomotor recovery between FMS group and non-FMS group (p<0.05). Measurement of MEP was also indicated that amplitude of MEP in FMS group is larger than that in non-FMS group.
Conclusion
These results indicate that FMS may have beneficial effects on motor recovery after spinal cord injury and the benefits of FMS could be an additional non-invasive therapeutic method for clinical trials in patients with spinal cord injury. (J Korean Acad Rehab Med 2008; 32: 612- 618)
Key Words: Functional magnetic stimulation, Spinal cord injury, Motor recovery, Motor evoked potential, Somatosensory evoked potential


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