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Journal of the Korean Academy of Rehabilitation Medicine 2010;34(3):259-264.
Effects of Continuous Repetitive Transcranial Magnetic Stimulation on Pain Response in Spinal Cord Injured Rat.
Bae, Young Kyung , Kim, Su Jeong , Seo, Jeong Min , Cho, Yun Woo , Ahn, Sang Ho , Kang, In Soon , Park, Hea Woon , Hwang, Se Jin
1Department of Pathology, College of Medicine, Yeungnam University, Korea.
2Institute of Medical Science, Yeungnam University, Korea.
3Department of Molecular Medicine, Kyungpook National University School of Medicine, Korea.
4Department of Rehabilitation Medicine, College of Medicine, Yeungnam University, Korea.
5Department of Rehabilitation Medicine, School of Medicine, Catholic University of Daegu, Korea. hwprm@cu.ac.kr
6Department of Anatomy and Cell Biology, College of Medicine, Hanyang University, Korea.
척수손상 흰쥐의 통증에 대한 지속적인 반복 경두개 자기자극의 효과
배영경, 김수정1, 서정민2, 조윤우3, 안상호3, 강인순4, 박해운4, 황세진5
영남대학교 의과대학 병리학교실, 1영남대학교 의과학연구소, 2경북대학교 의학전문대학원 분자의학교실, 3영남대학교 의과대학 재활의학교실, 4대구가톨릭대학교 의과대학 재활의학교실, 5한양대학교 의과대학 해부세포생물학교실
Abstract
Objective
To investigate the effects of continuous repetitive transcranial magnetic stimulation (rTMS) on pain response in spinal cord injured rat.
Method
Forty Sprague-Dawley rats (200∼250 grams, female) were used. Thoracic spinal cord (T9) was contused using New York University (NYU) spinal cord impactor. Ten gram weight rod was dropped from a height of 25 mm to produce spinal cord contusion model with moderate injury. The animals were randomly assigned to two groups: one exposed to real magnetic stimulation (real-rTMS group) and the other not exposed to magnetic stimulation (sham- rTMS group). rTMS was applied for 8 weeks. To assess the effect of continuous rTMS on below-level pain responses after spinal cord injury (SCI), the hindpaw withdrawal response for thermal stimuli, cold stimuli and mechanical stimuli were compared between two groups.
Results
Behavioral response for pain showed that hindpaw withdrawal response for cold stimuli was reduced significantly from 4 weeks after SCI in real-rTMS group compared with sham group (p<0.05).
Conclusion
These results suggest that continuous rTMS may have beneficial effects on attenuation of cold allodynia after SCI, and it might be an additional non-invasive therapeutic method in patients with chronic neuropathic pain after SCI. (J Korean Acad Rehab Med 2010; 34: 259-264)
Key Words: Repetitive transcranial magnetic stimulation (rTMS), Spinal cord injury, Neuropathic pain, Cold allodynia


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