Objective To assess the clinical efficacy and safety of intra-articular injection of hyaluronic acid (HA) combined with polydeoxyribonucleotide (PDRN) in patients with knee osteoarthritis in comparison with that of HA alone.
Methods The current single-center, prospective, randomized, double-blind, controlled study was conducted in 36 patients with knee osteoarthritis at our medical institution. All the eligible patients (n=30) were equally assigned to two treatment arms (trial group ‘HA+PDRN’ and control group ‘HA’). For efficacy assessment, the patients were evaluated for the visual analogue scale (VAS) scores, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Knee Society Scores (KSS), all of which served as efficacy outcome measures. We monitored time-dependent changes in efficacy outcome measures at baseline and 1, 3 and 6 months. Subsequently, we compared differences in changes in efficacy outcome measures at 6 months from baseline between the two groups. Moreover, we assessed the safety based on the treatment-emergent adverse events (TEAEs), adverse drug reactions (ADRs) and any other complications serving as safety outcome measures.
Results There were significant differences in changes in the VAS scores, the WOMAC scores in all domains, except ‘Stiffness’, the total WOMAC scores, and the KSS scores in all the domains at 6 months from baseline between the two groups (p<0.05). In our series, there were no TEAEs, ADRs, and any other complications.
Conclusion Intra-articular injections of HA combined with PDRN can also be considered in the treatment of knee osteoarthritis. However, further large-scale and multi-center studies are required to demonstrate the potential of the proposed combination.
Citations
Citations to this article as recorded by
Emerging wound-healing injectable polydeoxyribonucleotide: potential as a prohibited doping method and its simple detection via CRISPR/Cas12a system Joon-Yeop Yi, Sanghwa Park, Minyoung Kim, Yujin Jeong, HyunA Shin, Yeojeong Cho, Mijin Jeon, Min-Kyu Oh, Changmin Sung International Journal of Biological Macromolecules.2025; 309: 142999. CrossRef
Polydeoxyribonucleotide as a Regenerative Agent in Dermatology and Wound Healing: Mechanisms, Clinical Applications, and Safety Gi Young Park, Byeong-Churl Jang Keimyung Medical Journal.2025; 44(1): 9. CrossRef
Points to ponder on the role of polynucleotides in regenerative and aesthetic medicine: a systematic review William Richard Webb, Eqram Rahman, Parinitha Rao, Hany Niamey Abu-Farsakh, Nanze Yu, Patricia E. Garcia, Sotirios Ioannidis, Karim Sayed, Elias Tam, Wolfgang G. Philipp-Dormston, Mohammad Najlah, Zakia Rahman, Jean D. A. Carruthers, Ash Mosahebi European Journal of Plastic Surgery.2024;[Epub] CrossRef
An injectable hyaluronic acid-Polydeoxyribonucleotides (HA-PDRN) crosslinked hydrogel as a dermal filler Guo jiahong, Fang wei, Wang feifei European Polymer Journal.2024; 219: 113395. CrossRef
Recent advances on polydeoxyribonucleotide extraction and its novel application in cosmeceuticals Thi Hanh Nguyen, San-Lang Wang, Van Bon Nguyen International Journal of Biological Macromolecules.2024; 282: 137051. CrossRef
Injectable “Skin Boosters” in Aging Skin Rejuvenation: A Current Overview Nark-Kyoung Rho, Hyun-Seok Kim, Soo-Young Kim, Won Lee Archives of Plastic Surgery.2024; 51(06): 528. CrossRef
Clinical Updates in Polydeoxyribonucleotide Injection Tae-Yeong Kim, Yong-Tae Kim, Jung-Taek Hwang Journal of the Korean Orthopaedic Association.2024; 59(6): 386. CrossRef
Pseudoseptic Reaction to an Intra-Articular Polydeoxyribonucleotide Injection into the Ankle: A Case Report Seungcheol Yu, Hangaram Kim, Youngwoong Choi, Jeongsoo Kim International journal of Pain.2024; 15(2): 106. CrossRef
Intra-articular injections of polynucleotides for joint preconditioning before the injections of bionic cross-link hyaluronic acid. Case report Irina S. Svintsitskaya, Konstantin Yu. Volkov, Aleksei Chetaikin Storm Terapevticheskii arkhiv.2024; 96(12): 1238. CrossRef
Therapeutic effects of polydeoxyribonucleotide in an in vitro neuronal model of ischemia/reperfusion injury Seongmoon Jo, Ahreum Baek, Yoonhee Cho, Sung Hoon Kim, Dawoon Baek, Jihye Hwang, Sung-Rae Cho, Hyun Jung Kim Scientific Reports.2023;[Epub] CrossRef
Skin boosters – The upcoming boom in cosmetic dermatology for healthy skin Maya Vedamurthy, Vaishnavi Duvvuru, Vijaya Lakshmi Chelikani Cosmoderma.2023; 3: 82. CrossRef
Role and Effectiveness of Intra-articular Injection of Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Systematic Review Sumant Chavda, Syed Arman Rabbani, Tarun Wadhwa Cureus.2022;[Epub] CrossRef
Polydeoxyribonucleotide: A promising skin anti-aging agent Aawrish Khan, Guobao Wang, Feng Zhou, Lunli Gong, Jun Zhang, Lili Qi, Haiyan Cui Chinese Journal of Plastic and Reconstructive Surgery.2022; 4(4): 187. CrossRef
Adenosine A2A receptor agonist polydeoxyribonucleotide ameliorates short-term memory impairment by suppressing cerebral ischemia-induced inflammation via MAPK pathway Il-Gyu Ko, Jun-Jang Jin, Lakkyong Hwang, Sang-Hoon Kim, Chang-Ju Kim, Jung Won Jeon, Jun-Young Chung, Jin Hee Han, Giuseppe Pignataro PLOS ONE.2021; 16(3): e0248689. CrossRef
Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering Tae-Hee Kim, Seong-Yeong Heo, Gun-Woo Oh, Soo-Jin Heo, Won-Kyo Jung Marine Drugs.2021; 19(6): 296. CrossRef
Mesenchymal Stem Cells Use in the Treatment of Tendon Disorders: A Systematic Review and Meta-Analysis of Prospective Clinical Studies Woo Sup Cho, Sun Gun Chung, Won Kim, Chris H. Jo, Shi-Uk Lee, Sang Yoon Lee Annals of Rehabilitation Medicine.2021; 45(4): 274. CrossRef
Viscosupplementation in the Therapy for Osteoarthritic Knee Junghyun Park, Hue Jung Park, Min Cheol Rho, Jin Joo Applied Sciences.2021; 11(24): 11621. CrossRef
A Comprehensive Review of Viscosupplementation in Osteoarthritis of the Knee Jacquelin Peck, Annabel Slovek, Paulo Miro, Neeraj Vij, Blake Traube, Christopher Lee, Amnon A. Berger, Hisham Kassem, Alan D. Kaye, William F. Sherman, Alaa Abd-Elsayed Orthopedic Reviews.2021;[Epub] CrossRef
Polydeoxyribonucleotide Regulation of Inflammation Maria Teresa Colangelo, Carlo Galli, Stefano Guizzardi Advances in Wound Care.2020; 9(10): 576. CrossRef
The efficacy and safety of polydeoxyribonucleotide for the treatment of knee osteoarthritis Man Soo Kim, Ryu Kyoung Cho, Yong In Medicine.2019; 98(39): e17386. CrossRef
Polydeoxyribonucleotide (PDRN) is safe and effective in wound healing, cellular growth, synthesis of extracellular matrix protein, and inflammation reduction via activation of adenosine A2 receptors. We report a 28-year-old male patient treated with PDRN injections for chronic non-healing wound refractory to negative pressure wound therapy, skin graft, or growth factors. Three injections of PDRN were administered at the wound site into the anterior and medial sides of the left stump on the 1st, 4th, and 9th days of hospitalization. The PDRN ameliorated wound healing by enhancing cell growth, tissue repair, and angiogenesis. PDRN application represents a potential treatment for non-healing wounds obviating the need for additional therapies, and hospitalization, as well as improve patient’s activities of daily living.
Citations
Citations to this article as recorded by
An NIR-responsive hydrogel loaded with polydeoxyribonucleotide nano-vectors for enhanced chronic wound healing Yanzhen Sun, Yao Li, Xiaokang Ding, Pan Xu, Xiaodong Jing, Hailin Cong, Hao Hu, Bing Yu, Fu-Jian Xu Biomaterials.2025; 314: 122789. CrossRef
Non-surgical treatment of diabetic foot ulcers on the dorsum of the foot with polydeoxyribonucleotide injection: Two case reports Yooseok Ha, Jeong-Hee Kim, Jiyoung Kim, Hyeokjae Kwon World Journal of Clinical Cases.2024; 12(20): 4446. CrossRef
СУЧАСНІ МЕТОДИ ЛІКУВАННЯ РУБЦІВ ПІСЛЯ ЗАГОЄННЯ РАН, ОТРИМАНИХ ПІСЛЯ ВОГНЕПАЛЬНИХ ПОРАНЕНЬ І МІННО-ВИБУХОВИХ ТРАВМ РІЗНОГО ГЕНЕЗУ ТА ЛОКАЛІЗАЦІЇ У ВІЙСЬКОВИХ І. М. Салайда Здобутки клінічної і експериментальної медицини.2024; (2): 150. CrossRef
Analgesic Effect of Human Placenta Hydrolysate on CFA-Induced Inflammatory Pain in Mice Keun-Tae Park, Heejoon Jo, So-Hyun Jeon, Kyeongsoo Jeong, Minju Im, Jae-Won Kim, Jong-Pil Jung, Hoe Chang Jung, Jae hun Lee, Woojin Kim Pharmaceuticals.2024; 17(9): 1179. CrossRef
A chitosan derivative-crosslinked hydrogel with controllable release of polydeoxyribonucleotides for wound treatment Yanzhen Sun, Xiaodong Jing, Yang Liu, Bing Yu, Hao Hu, Hailin Cong, Youqing Shen Carbohydrate Polymers.2023; 300: 120298. CrossRef
Efficacy of Polydeoxyribonucleotide in Promoting the Healing of Diabetic Wounds in a Murine Model of Streptozotocin-Induced Diabetes: A Pilot Experiment Jiyoung Yun, SaeGwang Park, Ha Young Park, Kyung Ah Lee International Journal of Molecular Sciences.2023; 24(3): 1932. CrossRef
Rotator Cuff Tendon Regeneration Sang-Eun Park, Jong-Hun Ji, Hyun-Sik Jun Journal of the Korean Orthopaedic Association.2023; 58(5): 365. CrossRef
Topical Polydeoxyribonucleotide Loaded in Hydrogel Formulation for Wound Healing in Diabetic Rats Mariya Dmitriyeva, Timur Suleimenov, Daulet Yessenbayev, Dulat Turebayev, Saltanat Urazova, Mirsaid Izimbergenov, Saken Kozhakhmetov, Talgat Omarov, Medet Toleubayev Open Access Macedonian Journal of Medical Sciences.2022; 10(A): 198. CrossRef
Current Progress and Outlook of Nano-Based Hydrogel Dressings for Wound Healing Xiao Zhang, Pengyu Wei, Zhengyang Yang, Yishan Liu, Kairui Yang, Yuhao Cheng, Hongwei Yao, Zhongtao Zhang Pharmaceutics.2022; 15(1): 68. CrossRef
Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering Tae-Hee Kim, Seong-Yeong Heo, Gun-Woo Oh, Soo-Jin Heo, Won-Kyo Jung Marine Drugs.2021; 19(6): 296. CrossRef
Alginate/chitosan-based hydrogel loaded with gene vectors to deliver polydeoxyribonucleotide for effective wound healing Xiaodong Jing, Yanzhen Sun, Yang Liu, Xiaoli Ma, Hao Hu Biomaterials Science.2021; 9(16): 5533. CrossRef
Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing Da Yong Shin, Ji-Ung Park, Min-Ha Choi, Sukwha Kim, Hyoun-Ee Kim, Seol-Ha Jeong Scientific Reports.2020;[Epub] CrossRef
The Effects of Polydeoxyribonucleotide on Wound Healing and Tissue Regeneration: A Systematic Review of the Literature Maria T Colangelo, Carlo Galli, Stefano Guizzardi Regenerative Medicine.2020; 15(6): 1801. CrossRef
First
Prev
