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"Locomotion"

Review Article

Spinal cord injury

Robot-Assisted Gait Training in Individuals With Spinal Cord Injury: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Jong Mi Park, Yong Wook Kim, Su Ji Lee, Ji Cheol Shin
Ann Rehabil Med 2024;48(3):171-191.   Published online June 28, 2024
DOI: https://doi.org/10.5535/arm.230039
Spinal cord injury (SCI) rehabilitation emphasizes locomotion. Robotic-assisted gait training (RAGT) is widely used in clinical settings because of its benefits; however, its efficacy remains controversial. We conducted a systematic review and meta-analysis to investigate the efficacy of RAGT in patients with SCI. We searched international and domestic databases for articles published until April 18, 2024. The meta-analysis employed a random effects model to determine the effect size as either mean difference (MD) or standardized MD (SMD). Evidence quality was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Twenty-three studies with a total of 690 participants were included in the final analysis. The overall pooled effect size for improvement in activities of daily living was 0.24, with SMD (95% confidence interval [95% CI], 0.04–0.43; GRADE: high) favoring RAGT over conventional rehabilitation. Muscular strength (MD, 0.23; 95% CI, 0.02–0.44; GRADE: high), walking index for SCI (MD, 0.31; 95% CI, 0.07–0.55; GRADE: moderate) and 6 min walk test distance (MD, 0.38; 95% CI, 0.14–0.63; GRADE: moderate) showed significant improvement in the robot group. Subgroup analysis revealed that subacute patients and intervention periods >2 months were more effective. This meta-analysis revealed that RAGT significantly improved activities of daily living, muscular strength, and walking abilities. Additional studies are needed to identify the optimal treatment protocol and specific patient groups for which the protocol is most effective.

Citations

Citations to this article as recorded by  
  • Effects of Unpredictable Perturbation Training on a Split-Belt Treadmill on Physical Performance in Older Adults: A Randomized Controlled Trial
    Kap-Soo Han, Myoung-Hwan Ko
    Geriatrics.2025; 10(1): 23.     CrossRef
  • Advances and New Therapies in Traumatic Spinal Cord Injury
    Antonio Montoto-Marqués, Jesús Benito-Penalva, María Elena Ferreiro-Velasco, Mark Andrew Wright, Sebastian Salvador-De la Barrera, Hatice Kumru, Nelson Gaitán-Pérez, Agustin Hernández-Navarro, Antonio Rodríguez-Sotillo, Fernando Martins Braga, Angela Pale
    Journal of Clinical Medicine.2025; 14(7): 2203.     CrossRef
  • Factors influencing on functional independence outcomes after hospitalization and rehabilitation in children with spinal cord injury
    Hong-Bo Zhao, Xiang-Jiang Rong, Qi Zhang, Ting-Ting Ma, He Yan, Tian-Tian Zhou, Yan-Qing Zhang
    BMC Pediatrics.2025;[Epub]     CrossRef
  • 4,983 View
  • 153 Download
  • 3 Web of Science
  • 3 Crossref
Original Articles

Brain disorders

Feasibility and Usability of a Robot-Assisted Complex Upper and Lower Limb Rehabilitation System in Patients with Stroke: A Pilot Study
Kyoung Tae Kim, Yongmin Choi, Jang Hyuk Cho, Soyoung Lee
Ann Rehabil Med 2023;47(2):108-117.   Published online April 30, 2023
DOI: https://doi.org/10.5535/arm.23017
Objective
To evaluate the feasibility and usability of cost-effective complex upper and lower limb robot-assisted gait training in patients with stroke using the GTR-A, a foot-plate based end-effector type robotic device.
Methods
Patients with subacute stroke (n=9) were included in this study. The enrolled patients received 30-minute robot-assisted gait training thrice a week for 2 weeks (6 sessions). The hand grip strength, functional ambulation categories, modified Barthel index, muscle strength test sum score, Berg Balance Scale, Timed Up and Go Test, and Short Physical Performance Battery were used as functional assessments. The heart rate was measured to evaluate cardiorespiratory fitness. A structured questionnaire was used to evaluate the usability of robot-assisted gait training. All the parameters were evaluated before and after the robot-assisted gait training program.
Results
Eight patients completed robot-assisted gait training, and all parameters of functional assessment significantly improved between baseline and posttraining, except for hand grip strength and muscle strength test score. The mean scores for each domain of the questionnaire were as follows: safety, 4.40±0.35; effects, 4.23±0.31; efficiency, 4.22±0.77; and satisfaction, 4.41±0.25.
Conclusion
Thus, the GTR-A is a feasible and safe robotic device for patients with gait impairment after stroke, resulting in improvement of ambulatory function and performance of activities of daily living with endurance training. Further research including various diseases and larger sample groups is necessary to verify the utility of this device.

Citations

Citations to this article as recorded by  
  • Changes in body composition, physical fitness and quality of life on robotic gait assisted training in patients with Guillain-Barré Syndrome: a case report
    Moon Jin Lee, Sung Jin Yoon
    Physical Activity and Nutrition.2024; 28(4): 009.     CrossRef
  • Smart Devices for Health and Wellness Applied to Tele-Exercise: An Overview of New Trends and Technologies Such as IoT and AI
    Antonio Fabbrizio, Alberto Fucarino, Manuela Cantoia, Andrea De Giorgio, Nuno D. Garrido, Enzo Iuliano, Victor Machado Reis, Martina Sausa, José Vilaça-Alves, Giovanna Zimatore, Carlo Baldari, Filippo Macaluso
    Healthcare.2023; 11(12): 1805.     CrossRef
  • 5,064 View
  • 114 Download
  • 1 Web of Science
  • 2 Crossref
Degree of Contribution of Motor and Sensory Scores to Predict Gait Ability in Patients With Incomplete Spinal Cord Injury
Jinkyoo Moon, Junghoon Yu, Jaewoo Choi, MinYoung Kim, Kyunghoon Min
Ann Rehabil Med 2017;41(6):969-978.   Published online December 28, 2017
DOI: https://doi.org/10.5535/arm.2017.41.6.969
Objective

To identify different contributions of motor and sensory variables for independent ambulation of patients with incomplete spinal cord injury (SCI), and reveal the most significant contributors among the variables.

Methods

The retrospective study included 30 patients with incomplete SCI and lesions were confirmed by magnetic resonance imaging. Motor and sensory scores were collected according to the International Standards for Neurological Classification of Spinal Cord Injury. The variables were analyzed by plotting ROC (receiver operating characteristic) curves to estimate their differential contributions for independent walking. The most significant functional determinant was identified through the subsequent logistic regression analysis.

Results

Motor and sensory scores were significantly different between the ambulators and non-ambulators. The majority was associated to the function of lower extremities. Calculation of area under ROC curves (AUC) revealed that strength of hip flexor (L2) (AUC=0.905, p<0.001) and knee extensor (L3) (AUC=0.820, p=0.006) contributed the greatest to independent walking. Also, hip flexor strength (L2) was the single most powerful predictor of ambulation by the logistic regression analysis (odds ratio=6.3, p=0.049), and the model fit well to the data.

Conclusion

The most important potential contributor for independent walking in patients with incomplete SCI is the muscle strength of hip flexors, followed by knee extensors compared with other sensory and motor variables.

Citations

Citations to this article as recorded by  
  • Classifying clinical phenotypes of functional recovery for acute traumatic spinal cord injury. An observational cohort study
    Pascal Mputu Mputu, Marie Beauséjour, Andréane Richard-Denis, Nader Fallah, Vanessa K. Noonan, Jean-Marc Mac-Thiong
    Disability and Rehabilitation.2024; 46(25): 6069.     CrossRef
  • Gait recovery in patients with late assessment of incomplete spinal cord injury: A retrospective study in Argentina
    Marcelo A. Gatti, Yamila Dieni, Lucia Yaccuzzi, María E. Rivas, Daniela G. L. Terson de Paleville
    The Journal of Spinal Cord Medicine.2024; : 1.     CrossRef
  • Walking Outcome After Traumatic Paraplegic Spinal Cord Injury: The Function of Which Myotomes Makes a Difference?
    Adrian Cathomen, Doris Maier, Jiri Kriz, Rainer Abel, Frank Röhrich, Michael Baumberger, Giorgio Scivoletto, Norbert Weidner, Rüdiger Rupp, Catherine R. Jutzeler, John D. Steeves, Armin Curt, Marc Bolliger
    Neurorehabilitation and Neural Repair.2023; 37(5): 316.     CrossRef
  • Development of an unsupervised machine learning algorithm for the prognostication of walking ability in spinal cord injury patients
    Zachary DeVries, Mohamad Hoda, Carly S Rivers, Audrey Maher, Eugene Wai, Dita Moravek, Alexandra Stratton, Stephen Kingwell, Nader Fallah, Jérôme Paquet, Philippe Phan
    The Spine Journal.2020; 20(2): 213.     CrossRef
  • Does prolonged walking cause greater muscle fatigability in individuals with incomplete spinal cord injury compared with matched-controls?
    Jefferson Rodrigues Dorneles, Frederico Ribeiro Neto, Carlos Wellington Gonçalves, Rodrigo Rodrigues Gomes Costa, Rodrigo Luiz Carregaro
    Gait & Posture.2020; 78: 65.     CrossRef
  • Gait rehabilitation in persons with spinal cord injury using innovative technologies: an observational study
    Giulia Stampacchia, Matteo Olivieri, Alessandro Rustici, Carla D’Avino, Adriana Gerini, Stefano Mazzoleni
    Spinal Cord.2020; 58(9): 988.     CrossRef
  • 6,525 View
  • 98 Download
  • 7 Web of Science
  • 6 Crossref
Improved Gait Speed After Robot-Assisted Gait Training in Patients With Motor Incomplete Spinal Cord Injury: A Preliminary Study
Seungwon Hwang, Hye-Ri Kim, Zee-A Han, Bum-Suk Lee, Soojeong Kim, Hyunsoo Shin, Jae-Gun Moon, Sung-Phil Yang, Mun-Hee Lim, Duk-Youn Cho, Hayeon Kim, Hye-Jin Lee
Ann Rehabil Med 2017;41(1):34-41.   Published online February 28, 2017
DOI: https://doi.org/10.5535/arm.2017.41.1.34
Objective

To evaluate the clinical features that could serve as predictive factors for improvement in gait speed after robotic treatment.

Methods

A total of 29 patients with motor incomplete spinal cord injury received 4-week robot-assisted gait training (RAGT) on the Lokomat (Hocoma AG, Volketswil, Switzerland) for 30 minutes, once a day, 5 times a week, for a total of 20 sessions. All subjects were evaluated for general characteristics, the 10-Meter Walk Test (10MWT), the Lower Extremity Motor Score (LEMS), the Functional Ambulatory Category (FAC), the Walking Index for Spinal Cord Injury version II (WISCI-II), the Berg Balance Scale (BBS), and the Spinal Cord Independence Measure version III (SCIM-III) every 0, and 4 weeks. After all the interventions, subjects were stratified using the 10MWT score at 4 weeks into improved group and non-improved group for statistical analysis.

Results

The improved group had younger age and shorter disease duration than the non-improved group. All subjects with the American Spinal Injury Association Impairment Scale level C (AIS-C) tetraplegia belonged to the non-improved group, while most subjects with AIS-C paraplegia, AIS-D tetraplegia, and AIS-D paraplegia belonged to the improved group. The improved group showed greater baseline lower extremity strength, balance, and daily living function than the non-improved group.

Conclusion

Assessment of SCIM-III, BBS, and trunk control, in addition to LEMS, have potential for predicting the effects of robotic treatment in patients with motor incomplete spinal cord injury.

Citations

Citations to this article as recorded by  
  • The Effect of Assistive Robotic Technologies on Quality of Life and Functional Independence in Individuals with Spinal Cord Injury
    Abdurrahim Yıldız, Rüstem Mustafaoğlu, Nur Kesiktaş
    Journal of Basic and Clinical Health Sciences.2024; 8(3): 580.     CrossRef
  • Gait quality after robot therapy compared with physiotherapy in the patient with incomplete spinal cord injured: A systematic review
    Isabella Fabbri, Fabio Betti, Roberto Tedeschi
    eNeurologicalSci.2023; : 100467.     CrossRef
  • Clinical Utility of Robot-Assisted Gait Training in Patients with Spinal Cord Injury Caused by Electrical Burns: A Case Report
    Seung-Yeol Lee, Cheong-Hoon Seo, Yoon-Soo Cho, So-Young Joo
    Journal of Clinical Medicine.2023; 12(23): 7220.     CrossRef
  • Settings matter: a scoping review on parameters in robot-assisted gait therapy identifies the importance of reporting standards
    Florian van Dellen, Rob Labruyère
    Journal of NeuroEngineering and Rehabilitation.2022;[Epub]     CrossRef
  • Feasibility of Overground Gait Training Using a Joint-Torque-Assisting Wearable Exoskeletal Robot in Children with Static Brain Injury
    Juntaek Hong, Jongweon Lee, Taeyoung Choi, Wooin Choi, Taeyong Kim, Kyuwan Kwak, Seongjun Kim, Kyeongyeol Kim, Daehyun Kim
    Sensors.2022; 22(10): 3870.     CrossRef
  • A Survey on Socially Assistive Robotics: Clinicians’ and Patients’ Perception of a Social Robot within Gait Rehabilitation Therapies
    Denniss Raigoso, Nathalia Céspedes, Carlos A. Cifuentes, Antonio J. del-Ama, Marcela Múnera
    Brain Sciences.2021; 11(6): 738.     CrossRef
  • Social Human-Robot Interaction for Gait Rehabilitation
    Nathalia Cespedes, Marcela Munera, Catalina Gomez, Carlos A. Cifuentes
    IEEE Transactions on Neural Systems and Rehabilitation Engineering.2020; 28(6): 1299.     CrossRef
  • Morning Walk®-Assisted Gait Training Improves Walking Ability and Balance in Patients with Ataxia: a Randomized Controlled Trial
    Chul Jung, Dae Yul Kim, Sara Kwon, Min Ho Chun, JaYoung Kim, Sung Hyun Kim
    Brain & Neurorehabilitation.2020;[Epub]     CrossRef
  • 7,287 View
  • 239 Download
  • 11 Web of Science
  • 8 Crossref
Korean Version of the ABILOCO Questionnaire in the Assessment of Locomotion in Hemiplegic Stroke Patients
Won Joon Lee, Geun Young Park, Zee A Han, Hye Won Kim, Sei Un Cho, Seon Jeong Oh, Hyun Mi Oh, Sun Im
Ann Rehabil Med 2013;37(1):72-81.   Published online February 28, 2013
DOI: https://doi.org/10.5535/arm.2013.37.1.72
Objective

To investigate the intra- and inter-rater reliability of the Korean version of the ABILOCO questionnaire (K-ABILOCO).

Methods

The original ABILOCO questionnaire was translated into Korean and back-translated into English. Stroke patients (n=30) with hemiplegia were evaluated using the K-ABILOCO at one week interval. At each visit, the physiatrist also evaluated patient performance of the activities described in the K-ABILOCO, and the total logit scores were recorded. The total scores were used to evaluate intraclass correlation (ICC). Test-retest scores and each test scores were compared to obtain the intra- and inter-rater reliability.

Results

The K-ABILOCO showed good intra-rater correlation at one week interval in both patient and physiatrist evaluations (ICC=0.81, 0.91), respectively. It also showed a high inter-rater correlation between the patient and physiatrist at both the first and second visits (ICC=0.76, 0.84), respectively.

Conclusion

The K-ABILOCO is a useful tool that may reliably evaluate the locomotion ability in hemiplegic stroke patients.

Citations

Citations to this article as recorded by  
  • Psychometric Properties of the Turkish Version of the Abiloco: Factor Analysis
    Esra Keskin, Ayşe Livanelioğlu
    Evaluation & the Health Professions.2024; 47(1): 119.     CrossRef
  • Validity and reliability of the Arabic quick disabilities of the arm, Shoulder and Hand (QuickDASH-Arabic)
    Ali H. Alnahdi
    Musculoskeletal Science and Practice.2021; 53: 102372.     CrossRef
  • Walking speed best explains perceived locomotion ability in ambulatory people with chronic stroke, assessed by the ABILOCO questionnaire
    Patrick R. Avelino, Kênia K.P. Menezes, Lucas Rodrigues Nascimento, Iza Faria-Fortini, Christina Danielle Coelho de Morais Faria, Luci F. Teixeira-Salmela
    Brazilian Journal of Physical Therapy.2019; 23(5): 412.     CrossRef
  • Test‐Retest Reliability of the ABILOCO Questionnaire in Individuals with Stroke
    Kênia K. P. de Menezes, Patrick R. Avelino, Iza Faria‐Fortini, Marluce L. Basílio, Lucas R. Nascimento, Luci F. Teixeira‐Salmela
    PM&R.2019; 11(8): 843.     CrossRef
  • The Effects of Botulinum Toxin Injections on Plantar Flexor Spasticity in Different Phases After Stroke: A Secondary Analysis From a Double‐Blind, Randomized Trial
    Hyun‐Mi Oh, Geun‐Young Park, Young Min Choi, Hyung Jung Koo, Yongjun Jang, Sun Im
    PM&R.2018; 10(8): 789.     CrossRef
  • Assessing Locomotion Ability in West African Stroke Patients: Validation of ABILOCO-Benin Scale
    Emmanuel Sègnon Sogbossi, Jean-Louis Thonnard, Charles Sèbiyo Batcho
    Archives of Physical Medicine and Rehabilitation.2014; 95(8): 1470.     CrossRef
  • Does botulinum toxin injection site determine outcome in post-stroke plantarflexion spasticity? Comparison study of two injection sites in the gastrocnemius muscle: a randomized double-blind controlled trial
    Sun Im, Joo Hyun Park, Seong Kon Son, Jae-Eun Shin, Sae Hoon Cho, Geun-Young Park
    Clinical Rehabilitation.2014; 28(6): 604.     CrossRef
  • 4,923 View
  • 31 Download
  • 7 Crossref
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