To investigate the question of whether serum leptin levels might be associated with post-stroke depression.
We studied 130 patients who experienced a first episode of stroke of more than three months' duration, without any previous history of depression or speech disorders. Data were collected regarding the patient demographics, depressive mood (Diagnostic and Statistical Manual of Mental Disorders 4th edition [DSM-IV] criteria and Beck Depression Inventory) and serum leptin levels measured by an enzyme-linked immunosorbent assay (ELISA). In addition, the Korean version of Modified Barthel Index (K-MBI) and Korean version of Mini-Mental State Examination (K-MMSE) were used to assess the subjects' independence, in regard to the activities of daily living and cognition. A statistical analysis was performed to determine differences the serum leptin levels between patients with depression and those without depression, and to determine the difference in the MBI and K-MMSE scores between the groups separated according to the serum leptin levels.
Higher serum leptin levels were observed in patients with depression, compared with those without depression (38.5 ng/mL [range, 25.1-59.2 ng/mL] vs. 8.2 ng/mL [range, 4.9-17.8 ng/mL]; p<0.01. The serum leptin level showed an association with depression (odds ratio, 1.21; 95% confidence interval, 1.01-1.45; p=0.021). The K-MMSE and K-MBI improvement scores were lower, with statistical significance, in the group with the highest leptin level (>30 mg/dL), compared to the other two groups.
High serum leptin levels are associated with depression after stroke, and patients with elevated serum leptin levels were disadvantaged in regard to functional and cognitive outcomes.
Citations
Objective: To investigate the relationship between the plasma leptin concentration and bone metabolism in postmenopausal women with osteoporosis to improve the understanding of the role of leptin in controlling bone mass.
Method: Fifty four postmenopausal women (ages 64⁑8.59 years, body weights 58.14⁑6.92 kg) with osteoporosis were included. The biochemical markers of bone metabolism and serum leptin concentration were measured using the radioimmunoassay. Bone mineral densities were measured by dual energy X-ray absorptiometry. And we investigate the correlation between serum leptin concentration and the biochemical markers of bone metabolism or bone mineral density.
Results: The bone mineral densities were 0.639⁑0.130 g/cm2 in mid-lumbar area, 0.684⁑0.098 g/cm2 in femoral neck and 0.491⁑0.117 g/cm2 in Ward's triangle. The mean value of serum osteocalcin was 26.84⁑16.73 ng/ml, the mean value of urine deoxypyridinoline was 11.84⁑6.08 nmol/mmol Cr, and the plasma concentration of leptin was 11.51⁑8.64 ng/ml. There was no correlation between plasma leptin concentrations and the markers of bone metabolism or bone mineral density.
Conclusion: We could not confirm the significant correlation between the circulating leptin concentration and the bone mass in postmenopausal women. Our data suggest circulating plasma leptin does not have a significant direct influence on bone metabolism and bone mass in postmenopausal women.
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