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"Hypertrophic olivary degeneration"

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"Hypertrophic olivary degeneration"

Case Reports
Bilateral Hypertrophic Olivary Degeneration with Oculopalatal Tremor after Brainstem Hemorrhage: A case report.
Lee, Gyu Ho , Kim, Sei Joo , Yoon, Joon Shik , Jo, Jung Mo
J Korean Acad Rehabil Med 2010;34(1):96-98.
Hypertrophic olivary degeneration is a form of transynaptic degeneration, which is caused by a lesion in the dentate-rubro-olivary pathway. Commonly described lesions were brainstem stroke, neoplasm, demyelination, and trauma. It's clinical presentations are Holmes tremor, and palatal tremor. This case was a 49-year-old man who was diagnosed as bilateral brainstem hemorrhage. About 2 months later, he had developed bilateral Holmes tremor of upper extremities and oculopalatal termor. Brain MRI was performed at 13 months after onset. MRI showed hyperintense and hypertrophied lesion on T2-weighted image in both inferior olivary nuclei. (J Korean Acad Rehab Med 2010; 34: 96-98)
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Post-traumatic Hypertrophic Olivary Degeneration: A case report.
Choi, Hong Seok , Yoon, Chul Ho , Lee, Eun Shin , Kim, Jae Hyoung , Park, Young Sook , Shin, Dong Hoon , Shin, Hee Suk
J Korean Acad Rehabil Med 2002;26(4):480-484.

Hypertrophic olivary degeneration is usually caused by a lesion in the triangle of Guillain and Mollaret. The inciting pathology includes ischemic, inflammatory, degenerative or, less frequently, traumatic lesions. Clinically, it is usually accompanied by palatal myoclonus or other forms of segmental myoclonus. We present four patients with hypertrophic olivary degeneration studied with MRI after severe head trauma. MRI was performed between 5 and 18 months respectively after trauma. Although post-traumatic tremor was observed in three patients, none of patients showed palatal myoclonus. MRI showed multiple post-traumatic lesions within the dentato-rubro-olivary pathway associated with enlargement and increased signal intensity of the inferior olives. (J Korean Acad Rehab Med 2002; 26: 480-484)

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