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"Hyperostosis"

Original Article

Characteristics and Clinical Course of Dysphagia Caused by Anterior Cervical Osteophyte
Hee Eun Choi, Geun Yeol Jo, Woo Jin Kim, Hwan Kwon Do, Jun Koo Kwon, Se Heum Park
Ann Rehabil Med 2019;43(1):27-37.   Published online February 28, 2019
DOI: https://doi.org/10.5535/arm.2019.43.1.27
Objective
To investigate swallowing characteristics of patients with dysphagia caused by anterior cervical osteophytes (ACOs) and compare clinical courses according to treatment options.
Methods
A retrospective analysis of 1,866 videofluoroscopic swallowing studies (VFSS) of patients with ACOs from electronic medical records was performed. Patients with other diseases that could explain the dysphagia were excluded. Dysphagia characteristics and severity and clinical and radiological characteristics of subjects with ACOs were evaluated. Dysphagia characteristics and clinical course were compared among three treatment groups: surgical treatment, swallowing rehabilitation, and conservative treatment.
Results
Subjects were 22 men and 1 woman with a mean age of 78.69±8.01 years. The mean osteophyte thickness was 9.07±3.84 mm. It was significantly thicker in the surgical group than that in other groups (p=0.01). ACOs were most frequently found at C5 level. This level also had the thickest osteophytes. However, videofluoroscopic dysphagia scales (VDS) were not significantly different among the three treatment groups. The pharyngeal phase score of the VDS was significantly higher in the surgical group (p=0.041). Dysphagia severity was decreased significantly in the surgical group at 3 months after the initial VFSS (p=0.004).
Conclusion
The main swallowing characteristics in patients with ACOs were dysphagia features of the pharyngeal phase, including inappropriate airway protection, decreased laryngeal elevation, and reduced epiglottis inversion. When determining treatment options, it may be helpful to consider dysphagia severity at pharyngeal phase and osteophyte thickness.

Citations

Citations to this article as recorded by  
  • Cervical osteophytes resulting in dysphagia: A case report with literature review
    Hoshmand R. Asaad, Sivan H. Salih, Dana T. Gharib, Shaho F. Ahmed, Karokh F. HamaHussein, Deari A. Ismaeil, Hezha A. Mohammed, Azad S. Hattam, Sarwat T. San Ahmed, Twana Omer Saeed, Berun A. Abdalla, Fahmi H. Kakamad
    Radiology Case Reports.2026; 21(2): 752.     CrossRef
  • Esophageal and Oropharyngeal Dysphagia: Clinical Recommendations From the United European Gastroenterology and European Society for Neurogastroenterology and Motility
    Amir Mari, Francesco Calabrese, Andrea Pasta, Greta Lorenzon, Bas Weusten, Jutta Keller, Pierfrancesco Visaggi, Sabine Roman, Elisa Marabotto, Ram Dickman, Jordi Serra, Nicola De Bortoli, Paola Iovino, Daniel Pohl, Dan Dumitrascu, Mentore Ribolsi, Claudia
    United European Gastroenterology Journal.2025; 13(6): 855.     CrossRef
  • Ventral osteophytes of the first two cervical vertebrae as a cause of dysphagia, surgical treatment (clinical case)
    A. S. Nikitin, R. M. Nanaev, O. B. Kulakov, O. V. Levchenko
    Russian journal of neurosurgery.2025; 27(2): 113.     CrossRef
  • Advancing modified barium swallow pre-sorting with deep learning: a new paradigm for the first step analysis in X-ray swallowing study
    Shitong Mao, Mohamed A. Naser, Sheila Buoy, Kristy K. Brock, Katherine A. Hutcheson
    International Journal of Computer Assisted Radiology and Surgery.2025;[Epub]     CrossRef
  • Cervical Diffuse Idiopathic Skeletal Hyperostosis (DISH) as an Underrecognized Cause of Dysphagia: A Case Series and Review of the Literature
    Emmanouela Dionysia Laskaratou, Ioannis Sperelakis, Nikolaos Trygonis, Rozalia Dimitriou, Georgios Kontakis
    Cureus.2025;[Epub]     CrossRef
  • Dysphagia as the main symptom in anterior cervical spine osteophytes (Forestier disease and cervical spondylosis deformans). Case reports and literature review
    A.V. Trashin, N.V. Vikherev, E.M. Belov, V.A. Shamanin, V.V. Stepanenko
    Burdenko's Journal of Neurosurgery.2024; 88(2): 69.     CrossRef
  • A Case of Dysphagia Due to Large Osteophytic Lesions in the Cervical Spine: A Conservative Approach
    Christos Lyrtzis, Alexandros Poutoglidis, Athina Stamati, Nikolaos Lazaridis, George Paraskevas
    Cureus.2024;[Epub]     CrossRef
  • Diagnosis and Management of Anatomical Causes of Dysphagia: From Hypopharynx to Upper Esophagus
    Min Woo Park
    Journal of the Korean Dysphagia Society.2023; 13(1): 8.     CrossRef
  • The Impact of Cervical Spinal Disease on Pharyngeal Swallowing Function
    Rameen K. Walters, Rachana Gudipudi, Kate Davidson, Melissa Cooke, Jenna Barengo, Drasti Smyre, Kendrea L. Garand, Bonnie Martin-Harris, Maria G. Matheus, Shaun A. Nguyen, Ashli K. O'Rourke
    American Journal of Speech-Language Pathology.2023; 32(2): 565.     CrossRef
  • Anterior Cervical Spine Surgery Complicated With Dysphagia
    Liu Wei, Li Sulian, Li Tonglian, Zhang Yan, Liu Zongchao
    Orthopaedic Nursing.2023; 42(5): 297.     CrossRef
  • Spinal Osteophytosis: An Uncommon Cause of Dysphagia
    Andreia De Matos, Cristiane Macedo, Patrícia Afonso Mendes
    GE - Portuguese Journal of Gastroenterology.2022; 29(3): 215.     CrossRef
  • Disfagia por osteofitose cervical anterior: relato de caso
    Mateus Morais Aires, Gabriela Marie Fukumoto, Sarah Lima Ribeiro, Leonardo Haddad, Eliézia Helena de Lima Alvarenga
    CoDAS.2022;[Epub]     CrossRef
  • Zero‐Profile Implant System for Treatment of Dysphagia Caused by Noncontiguous Anterior Cervical Osteophytes—A Case Report with Literature Review
    Zihan Peng, Hao Liu, Ying Hong, Yang Meng
    Orthopaedic Surgery.2022; 14(10): 2782.     CrossRef
  • Giant Anterior Cervical Osteophyte Causing Dysphagia
    Sang Joon Kang, Hoe Jong Jeong, Won Cheol Jeong, Sang-Won Ha, Seung Min Kim
    Journal of the Korean Neurological Association.2022; 40(3): 267.     CrossRef
  • Aggravation of dysphagia after surgical removal of anterior cervical osteophytes: a case report
    Young-In Go, Gi-Wook Kim, Yu-Hui Won, Sung-Hee Park, Myoung-Hwan Ko, Jeong-Hwan Seo, Da-Sol Kim
    Journal of International Medical Research.2022;[Epub]     CrossRef
  • Anterior Cervical Osteophyte Resection for Treatment of Dysphagia
    Joshua M. Kolz, Mohammed A. Alvi, Atiq R. Bhatti, Marko N. Tomov, Mohamad Bydon, Arjun S. Sebastian, Benjamin D. Elder, Ahmad N. Nassr, Jeremy L. Fogelson, Bradford L. Currier, Brett A. Freedman
    Global Spine Journal.2021; 11(4): 488.     CrossRef
  • Hypertrophic anterior cervical osteophyte
    Takaomi Kobayashi, Alan Kawarai Lefor, Tadatsugu Morimoto
    Reumatología Clínica.2021; 17(9): 552.     CrossRef
  • Hypertrophic anterior cervical osteophyte
    Takaomi Kobayashi, Alan Kawarai Lefor, Tadatsugu Morimoto
    Reumatología Clínica (English Edition).2021; 17(9): 552.     CrossRef
  • Impact of Osteophytectomy on Swallowing Function in a Patient with Chronic Dysphagia
    Melissa M Howard, Justin Phillips, Stefan Henley, Sarah E. Green, Emily R. Rosario
    OBM Geriatrics.2021; 05(03): 1.     CrossRef
  • Ostéophytes vertébraux : une cause rare de dysphagie chez le sujet jeune
    M. Le Guen, G. Lahlou, S. Le Burel, T. Chaara, H. Nielly, H. Vanquaethem, L. Gilardin
    La Revue de Médecine Interne.2019; 40: A112.     CrossRef
  • 9,621 View
  • 157 Download
  • 14 Web of Science
  • 20 Crossref

Case Report

Surgical Treatments on Patients with Anterior Cervical Hyperostosis-Derived Dysphagia
Ah Rom Song, Hee Seung Yang, Eunjin Byun, Youngbae Kim, Kwan Ho Park, Kyung Lyul Kim
Ann Rehabil Med 2012;36(5):729-734.   Published online October 31, 2012
DOI: https://doi.org/10.5535/arm.2012.36.5.729

Anterior cervical hyperostosis may be a cause of dysphagia. For anterior cervical hyperostosis, medical or surgical treatments can be adhibited in view of the causative mechanisms and intensities of dysphagia. We report 3 cases of cervical hyperostosis-derived progressive dysphagia that underwent operation. Radiologic diagnosis and Video Fluoroscopic Swallowing Study were performed on the three patients for evaluation. One had history of recurrent aspiration pneumonia accompanied by weight loss, another complained of dysphagia only when swallowing pills, and the third experienced recurrence symptom with reossification. All patients reported gradual improvement of dysphagia immediately after their cervical osteophytes were resected through the anterior approach. In relation to postoperative improvement, however, they expressed different degrees of satisfaction according to severity of symptoms. Surgical treatment, performed for the anterior cervical hyperostosis-derived dysphagia, can immediately relieve symptoms of difficulty in swallowing. This might especially be considered as an appropriate treatment option for severe dysphagia.

Citations

Citations to this article as recorded by  
  • Outcomes of Open Osteophytectomy in Dysphagia Related to Cervical Osteophytes: A Systematic Review
    Raj Malhotra, Hamza Khan, Joseph Celidonio, Keshav Kumar, Rohan Suresh, Kenneth Yan
    Annals of Otology, Rhinology & Laryngology.2025;[Epub]     CrossRef
  • Quantitative analysis and stochastic modeling of osteophyte formation and growth process on human vertebrae based on radiographs: a follow-up study
    Tong Wu, Changxi Wang, Kang Li
    Scientific Reports.2024;[Epub]     CrossRef
  • The Impact of Cervical Spinal Disease on Pharyngeal Swallowing Function
    Rameen K. Walters, Rachana Gudipudi, Kate Davidson, Melissa Cooke, Jenna Barengo, Drasti Smyre, Kendrea L. Garand, Bonnie Martin-Harris, Maria G. Matheus, Shaun A. Nguyen, Ashli K. O'Rourke
    American Journal of Speech-Language Pathology.2023; 32(2): 565.     CrossRef
  • Diagnosis and Management of Anatomical Causes of Dysphagia: From Hypopharynx to Upper Esophagus
    Min Woo Park
    Journal of the Korean Dysphagia Society.2023; 13(1): 8.     CrossRef
  • Diffuse idiopathic skeletal hyperostosis of the cervical spine causing dysphagia and airway obstruction: an updated systematic review
    Netanja I. Harlianto, Jonneke S. Kuperus, Firdaus A.A. Mohamed Hoesein, Pim A. de Jong, Jacob A. de Ru, F. Cumhur Öner, Jorrit-Jan Verlaan
    The Spine Journal.2022; 22(9): 1490.     CrossRef
  • Dysphagie bei Erkrankungen der Halswirbelsäule
    R. Riepl, T. K. Hoffmann, E. Goldberg-Bockhorn, P. Richter, R. Reiter
    HNO.2019; 67(10): 801.     CrossRef
  • Early Detection of Anterior Cervical Osteophytes Causing Dysphagia by Esophagogastroduodenoscopy
    Min Su Chu, Han Seung Ryu, In Tae Hwang, Ki Chang Sohn, Dong Ho Jo, Byung Hun Lim, Suck Chei Choi
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2015; 15(3): 187.     CrossRef
  • Partial Epiglottoplasty for Pharyngeal Dysphagia due to Cervical Spine Pathology
    Nausheen Jamal, Andrew Erman, Dinesh K. Chhetri
    Otolaryngology–Head and Neck Surgery.2015; 153(4): 586.     CrossRef
  • Anterior Herniation of Partially Calcified and Degenerated Cervical Disc Causing Dysphagia
    Cagatay Ozdol, Cezmi Cagri Turk, Ali Erdem Yildirim, Ali Dalgic
    Asian Spine Journal.2015; 9(4): 612.     CrossRef
  • Presentation and treatment of anterior cervical hyperostosis
    MC Quaye, JL Fowler, JT Griffiths
    The Annals of The Royal College of Surgeons of England.2015; 97(6): e85.     CrossRef
  • Dysphagia produced by cervical spine osteophyte. A case report
    Claudio Silveri, Juan Manuel Velasco, Asdrúbal Silveri
    Coluna/Columna.2014; 13(2): 150.     CrossRef
  • 7,359 View
  • 58 Download
  • 11 Crossref

Original Articles

The Prevalence and Clinical Features of Diffuse Idiopathic Skeletal Hyperostosis in the Patients with Dorsal Back Pain.
Park, Yun Hee , Sung, Duk Hyun , Huh, Jung Phil , Kwon, Jong Won
J Korean Acad Rehabil Med 2009;33(5):564-571.
Objective
To investigate the prevalence and clinical features of diffuse idiopathic skeletal hyperostosis (DISH) in patients with dorsal back pain. Method: A total of 229 patients (119 men and 110 women) with dorsal back pain were included. Medical records including age, sex, chief complaints, medical history, physical findings, laboratory data, and musculoskeletal radiographs were reviewed retrospectively. Results: Twenty-seven (11.8%, by Resnick's criteria) and thirty-eight (16.6%, by Julkunen's criteria) of the 229 patients were diagnosed with DISH by thoracic spine radiographs. A significant increase of risk with age was observed (Resnick's criteria: odds ratio 1.10, 95% CI 1.05∼1.16, p< 0.001, Julkunen's criteria: odds ratio 1.08, 95% CI 1.04∼1.12, p<0.001). Male sex (Resnick's criteria: odds ratio 2.65, 95% CI 1.01∼6.95, p=0.048, Julkunen's criteria: odds ratio 2.87, 95% CI 1.27∼6.59, p=0.011) and inflammatory pain (Resnick's criteria: odds ratio 7.76, 95% CI 2.69∼22.33, p<0.001, Julkunen's criteria: odds ratio 3.84, 95% CI 1.55∼9.47, p=0.004) showed higher risk for development of DISH. Mean body mass index of patients with DISH were higher in all age groups, and they showed higher prevalence of DM and hyperlipidemia than general population. Conclusion: Patients with dorsal back pain showed higher prevalence of DISH than previous results with random samples. Aging, male sex and inflammatory pain might be a risk factor for development of DISH. Also, obesity, DM and hyperlipidemia might be strongly related with DISH. (J Korean Acad Rehab Med 2009; 33: 564-571)
  • 1,634 View
  • 12 Download
HLA-B27 Positive and HLA-B27 Negative Ankylosing Spondylitis: A Comparative Study in Diagnostic Process and Clinical Features.
Sung, Duk Hyun , Yoon, Young Cheol , Kim, Eun Jin , Park, Kwang Hong
J Korean Acad Rehabil Med 2007;31(2):220-227.
Objective
To investigate the differences in clinical and radiologic features between HLA-B27 positive ankylosing spondylitis (AS) and HLA B27 negative AS. Method: Ninety-nine consecutive patients who were suspected as AS in initial diagnostic process were studied. HLA-B27 was examined with microlymphocytotoxicity method in all patients. A radiologist and a physiatrist re- read plain pelvis radiographies of all patients. Difference in onset age and C-reactive protein (CRP) depending on HLA B27 status and an association between HLA B27 status and clinical and radiologic features were tested. Results: Sacroiliitis (≥bilateral grade 2) was identified in 63 of 77 patients with HLA B27 and 7 of 22 patients without HLA B27 through the re-reading process. Ten percent of definite AS was HLA B27 negative AS. Five of 22 patients without HLA B27 were diagnosed as diffuse idiopathic skeletal hyperostosis. There was a significant association between sacroiliitis (≥bilateral grade 2) and HLA B27 (p<0.05) in re-reading process. No significant difference was found in onset age, and CRP depending on HLA B27 status. No significant association was noted between HLA B27 and gender, clinical and radiologic features. Conclusion: HLA B27 is useful in diagnosing AS in patients with clinical features of AS and sacroiliitis (≥unilateral grade 1). None of clinical and radiologic parameters are associated with HLA B27 status. It does not make difference in onset age of AS. To make a more concrete conclusion, a study of a much larger number of HLA B27 negative AS patients will be necessary. (J Korean Acad Rehab Med 2007; 31: 220-227)
  • 2,536 View
  • 31 Download
Case Report
Spinal Cord Injury in Diffuse Idiopathic Skeletal Hyperostosis: A case report.
Kim, Jeong A , Han, Soo Jeong , Lee, Ju Kang , Lee, Chyung Ki
J Korean Acad Rehabil Med 1997;21(4):795-799.

Diffuse idiopathic skeletal hyperostosis(DISH) is a relatively common disorder. It is a noninflammatory disease occuring predominantly in middle aged elderly men characterized by calcification and ossification of the anterolateral aspects of vertebral column. It's clinical manifestations are minor: usually cervical stiffness, trunk stiffness and moderate pain. However some severe neurologic complications can occur due to spinal cord compression. We report a case with DISH who got spinal cord injury after minor trauma.

A 65-year-old man admitted to the neurosurgery department with a complaint of weakness in lower extremities and paresthesia in upper extremities which were developed after slip down. He had a 10 year history of slowly progressive neck stiffness and weakness in lower extremities. Plain X-ray does not reveal any evidence of fracture in cervical spine or sacroilitis but showed calcification of the anterior longitudinal ligament. The disc spaces were maintained well. MRI showed ossification of the posterior longitudinal ligament causing severe narrowing of the vertebral canal and compression of the spinal cord. Under the diagnosis of spinal cord injury with DISH, the patient was treated conservatively. Despite these treatment, neurologic impairment aggrevated. Surgical decompression of cervical and thoracolumbar spinal cord was done and the patient improved to the quadcane ambulation level.

  • 2,033 View
  • 14 Download
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