Sjogren's syndrome is an important but poorly recognized cause of peripheral neuropathy. Several forms of peripheral nerve dysfunction occur in Sjogren's syndrome, including trigeminal sensory neuropathy, mononeuropathy multiplex, distal sensorimotor polyneuropathy and pure sensory neuropathy. Rarely, chronic relapsing inflammatory polyneuropathy and multiple cranial neuropathies appear. This report described a patient with primary subacute pure sensory ataxic neuropathy associated with primary Sjogren's syndrome, who presented with ataxia and sensory loss of extremities. The possibility of subacute pure sensory ataxic neuropathy associated with Sjogren's syndrome should be considered in patient, especially middle aged women, who develop sensory neuropathy with ataxia and kinesthetic loss.

Objective
To reconfirm the relationship between the Fos expression and the pulsed radiofrequency which very few articles have reported. Method: Thirty-four male Sprague-Dawely rats were enrolled: 8 for lumbar 3rd dorsal root ganglion (DRG) stimulation, 4 for L3 and L4 DRGs, 5 for C5 and C6 DRGs, 8 for sham L3 DRGs, 5 for sham L3 and L4 DRGs, and 4 for sham C5 and C6 DRGs. Without laminectomy, each lumbar DRG was stimulated with PRF for 2 minutes 2 times with 42°C. Sham group was stimulated with PRF electrode but without any stimulation. Three hours after the stimulations, spinal cord was thin sectioned for immunohistochemistry and Fos expression was calculated. Individual sections were digitized with 4096 gray levels using a computer assisted image analysis system. With laminectomy, cervical DRGs was stimulated with the same method of lumbar DRGs. Sham stimulation was applied to the sham group. Results: No significant difference of Fos expression was observed on dorsal horn of rat in operated site, 3 hours later after operation, between the PRF and sham group in lumbar DRGs and the PRF and sham groups in cervical DRGs. Conclusion: The expression of Fos was not significantly related with the cervical and the lumbar DRGs stimulation with PRF. (J Korean Acad Rehab Med 2007; 31: 387-393)

Objective
To investigate the pain-related behaviors and the changes of CX3CR1 expression in the dorsal root ganglion (DRG) in a rat model of lumbar disc herniation. Method A total of 90 male Sprague-Dawley rats were used. A laminectomy was performed to expose left L5 nerve roots and corresponding DRG. Autologous nucleus puplosus was implanted on the left L5 nerve root proximal to the DRG without mechanical compression. Sham operation was also done with the same procedure as mentioned above. Thermal hyperalgesia and mechanical allodynia were assessed at 1, 5, 10, 20 and 30 days after surgery. Real time PCR and immunohistochemistry after behavioral test were performed. Results In the lumbar disc herniation rats, significant reduction of thermal withdrawal latency indicating thermal hyperalgesia was shown on the ipsilateral hindpaw on postoperative day 1 (p＜0.01) and peaked on day 10 (p＜0.05) and maintained throughout day 30 (p＜0.05). The reduction of mechanical allodynia threshold, indicating mechanical allodynia, was observed on the ipsilateral hindpaw on postoperative day 1 (p＜0.01) and continued throughout day 30 (p＜0.01). Real time PCR showed the decrease in mRNA expression of CX3CR1 in the ipsilateral DRG on day 1 (p＜0.05) and the significant increase on day 20 (p＜0.05). The immunoreactivity for CX3CR1 was also increased in ipsilateral DRG on day 10 and 20. Conclusion These data suggest that lumbar disc herniation induces thermal hyperalgesia and mechanical allodynia and upregulates the expression of CX3CR1 in dorsal root ganglion. Expression of CX3CR1 might be associated with subacute neuropathic pain after intervertebral disc herniation.