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Pain & Musculoskeletal rehabilitation

Effect of Soft Surface Stepping Exercise on Physical Activity Among Community-Dwelling Elderly: A Prospective Randomized Controlled Trial
Chonticha Kaewjoho, Puttipong Poncumhak, Pacharee Manoy, Suphannika Ladawan, Narongsak Khamnon
Ann Rehabil Med 2025;49(2):91-103.   Published online April 22, 2025
DOI: https://doi.org/10.5535/arm.240119
Objective
To investigate the effects of modified stepping exercises over six weeks on functional mobility and individual lower extremity muscle strength in community-dwelling older individuals.
Methods
This prospective randomized controlled trial design was conducted in thirty-two older adults who completed a modified stepping exercises program (n=16 for soft-surface stepping exercise; n=16 for firm-surface stepping exercise). These exercises were practiced for 50 minutes/day, three days/week, over six weeks. They were assessed for their functional mobility relating to levels of independence at baseline, after 4 weeks, after 6 weeks of intervention, and at 1 month after the last intervention sessions.
Results
Both groups showed significant improvements in functional mobility, lower extremity muscle strength, and walking speed after 4 and 6 weeks of intervention, as well as at the one-month follow-up. However, the soft-surface stepping exercise group exhibited significantly greater improvements in dynamic balance (p=0.035) and lower extremity muscle strength (p=0.015) compared to the firm-surface stepping exercise group after 6 weeks of intervention. Additionally, the soft-surface group demonstrated superior gains in hip flexor (p=0.041), hip extensor (p=0.047), hip adductor (p=0.026), and hip abductor strength (p=0.046), with these enhancements maintained at the one-month follow-up.
Conclusion
Soft-surface stepping exercise that involves whole-body movements offers a promising alternative to promote independence and safety among community-dwelling older adults. This study underscores the need for future research to evaluate the sustained impact of these benefits post-intervention, particularly during a retention period following the intervention.
  • 5,030 View
  • 111 Download
Efficacy and Safety of Intra-articular Injections of Hyaluronic Acid Combined With Polydeoxyribonucleotide in the Treatment of Knee Osteoarthritis
Seihee Yoon, Jung Joong Kang, Jungin Kim, Seunghun Park, Jong Moon Kim
Ann Rehabil Med 2019;43(2):204-214.   Published online April 30, 2019
DOI: https://doi.org/10.5535/arm.2019.43.2.204
Objective
To assess the clinical efficacy and safety of intra-articular injection of hyaluronic acid (HA) combined with polydeoxyribonucleotide (PDRN) in patients with knee osteoarthritis in comparison with that of HA alone.
Methods
The current single-center, prospective, randomized, double-blind, controlled study was conducted in 36 patients with knee osteoarthritis at our medical institution. All the eligible patients (n=30) were equally assigned to two treatment arms (trial group ‘HA+PDRN’ and control group ‘HA’). For efficacy assessment, the patients were evaluated for the visual analogue scale (VAS) scores, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Knee Society Scores (KSS), all of which served as efficacy outcome measures. We monitored time-dependent changes in efficacy outcome measures at baseline and 1, 3 and 6 months. Subsequently, we compared differences in changes in efficacy outcome measures at 6 months from baseline between the two groups. Moreover, we assessed the safety based on the treatment-emergent adverse events (TEAEs), adverse drug reactions (ADRs) and any other complications serving as safety outcome measures.
Results
There were significant differences in changes in the VAS scores, the WOMAC scores in all domains, except ‘Stiffness’, the total WOMAC scores, and the KSS scores in all the domains at 6 months from baseline between the two groups (p<0.05). In our series, there were no TEAEs, ADRs, and any other complications.
Conclusion
Intra-articular injections of HA combined with PDRN can also be considered in the treatment of knee osteoarthritis. However, further large-scale and multi-center studies are required to demonstrate the potential of the proposed combination.

Citations

Citations to this article as recorded by  
  • Nanoformulated PDRN Improves Anti‐Inflammatory and Wound Healing Activities
    Ji‐Hye Kang, Min Jeong Jeon, Sung‐Eun Kim, Won Kyung Hwang, Mi‐Young Lee
    Macromolecular Bioscience.2026;[Epub]     CrossRef
  • Emerging wound-healing injectable polydeoxyribonucleotide: potential as a prohibited doping method and its simple detection via CRISPR/Cas12a system
    Joon-Yeop Yi, Sanghwa Park, Minyoung Kim, Yujin Jeong, HyunA Shin, Yeojeong Cho, Mijin Jeon, Min-Kyu Oh, Changmin Sung
    International Journal of Biological Macromolecules.2025; 309: 142999.     CrossRef
  • Polydeoxyribonucleotide as a Regenerative Agent in Dermatology and Wound Healing: Mechanisms, Clinical Applications, and Safety
    Gi Young Park, Byeong-Churl Jang
    Keimyung Medical Journal.2025; 44(1): 9.     CrossRef
  • Polydeoxynucleotide (PDRN) Pharmacopuncture for Musculoskeletal Disorders: A Scoping Review of Treatment Protocols and Clinical Efficacy
    Taegwang Nam, Jeonghoon Lyu, Yujeong Kang, Seung-Yun Oh, Tae Han Yook
    Innovations in Acupuncture and Medicine.2025;[Epub]     CrossRef
  • The promising potential of polynucleotide injections for knee osteoarthritis: A systematic review of literature and meta‐analysis of randomized control trials
    Joseph Elphingstone, Michael Bowler, Pietro Conte, Giuseppe Anzillotti, Elizaveta Kon
    Journal of Experimental Orthopaedics.2025;[Epub]     CrossRef
  • PDRN: Research and Application Trends in Medical and Health Field
    宇石 黄
    Hans Journal of Biomedicine.2025; 15(06): 1095.     CrossRef
  • Points to ponder on the role of polynucleotides in regenerative and aesthetic medicine: a systematic review
    William Richard Webb, Eqram Rahman, Parinitha Rao, Hany Niamey Abu-Farsakh, Nanze Yu, Patricia E. Garcia, Sotirios Ioannidis, Karim Sayed, Elias Tam, Wolfgang G. Philipp-Dormston, Mohammad Najlah, Zakia Rahman, Jean D. A. Carruthers, Ash Mosahebi
    European Journal of Plastic Surgery.2024;[Epub]     CrossRef
  • An injectable hyaluronic acid-Polydeoxyribonucleotides (HA-PDRN) crosslinked hydrogel as a dermal filler
    Guo jiahong, Fang wei, Wang feifei
    European Polymer Journal.2024; 219: 113395.     CrossRef
  • Recent advances on polydeoxyribonucleotide extraction and its novel application in cosmeceuticals
    Thi Hanh Nguyen, San-Lang Wang, Van Bon Nguyen
    International Journal of Biological Macromolecules.2024; 282: 137051.     CrossRef
  • Injectable “Skin Boosters” in Aging Skin Rejuvenation: A Current Overview
    Nark-Kyoung Rho, Hyun-Seok Kim, Soo-Young Kim, Won Lee
    Archives of Plastic Surgery.2024; 51(06): 528.     CrossRef
  • Clinical Updates in Polydeoxyribonucleotide Injection
    Tae-Yeong Kim, Yong-Tae Kim, Jung-Taek Hwang
    Journal of the Korean Orthopaedic Association.2024; 59(6): 386.     CrossRef
  • Pseudoseptic Reaction to an Intra-Articular Polydeoxyribonucleotide Injection into the Ankle: A Case Report
    Seungcheol Yu, Hangaram Kim, Youngwoong Choi, Jeongsoo Kim
    International journal of Pain.2024; 15(2): 106.     CrossRef
  • Intra-articular injections of polynucleotides for joint preconditioning before the injections of bionic cross-link hyaluronic acid. Case report
    Irina S. Svintsitskaya, Konstantin Yu. Volkov, Aleksei Chetaikin Storm
    Terapevticheskii arkhiv.2024; 96(12): 1238.     CrossRef
  • Therapeutic effects of polydeoxyribonucleotide in an in vitro neuronal model of ischemia/reperfusion injury
    Seongmoon Jo, Ahreum Baek, Yoonhee Cho, Sung Hoon Kim, Dawoon Baek, Jihye Hwang, Sung-Rae Cho, Hyun Jung Kim
    Scientific Reports.2023;[Epub]     CrossRef
  • Skin boosters – The upcoming boom in cosmetic dermatology for healthy skin
    Maya Vedamurthy, Vaishnavi Duvvuru, Vijaya Lakshmi Chelikani
    Cosmoderma.2023; 3: 82.     CrossRef
  • Role and Effectiveness of Intra-articular Injection of Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Systematic Review
    Sumant Chavda, Syed Arman Rabbani, Tarun Wadhwa
    Cureus.2022;[Epub]     CrossRef
  • Polydeoxyribonucleotide: A promising skin anti-aging agent
    Aawrish Khan, Guobao Wang, Feng Zhou, Lunli Gong, Jun Zhang, Lili Qi, Haiyan Cui
    Chinese Journal of Plastic and Reconstructive Surgery.2022; 4(4): 187.     CrossRef
  • Adenosine A2A receptor agonist polydeoxyribonucleotide ameliorates short-term memory impairment by suppressing cerebral ischemia-induced inflammation via MAPK pathway
    Il-Gyu Ko, Jun-Jang Jin, Lakkyong Hwang, Sang-Hoon Kim, Chang-Ju Kim, Jung Won Jeon, Jun-Young Chung, Jin Hee Han, Giuseppe Pignataro
    PLOS ONE.2021; 16(3): e0248689.     CrossRef
  • Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering
    Tae-Hee Kim, Seong-Yeong Heo, Gun-Woo Oh, Soo-Jin Heo, Won-Kyo Jung
    Marine Drugs.2021; 19(6): 296.     CrossRef
  • Mesenchymal Stem Cells Use in the Treatment of Tendon Disorders: A Systematic Review and Meta-Analysis of Prospective Clinical Studies
    Woo Sup Cho, Sun Gun Chung, Won Kim, Chris H. Jo, Shi-Uk Lee, Sang Yoon Lee
    Annals of Rehabilitation Medicine.2021; 45(4): 274.     CrossRef
  • Viscosupplementation in the Therapy for Osteoarthritic Knee
    Junghyun Park, Hue Jung Park, Min Cheol Rho, Jin Joo
    Applied Sciences.2021; 11(24): 11621.     CrossRef
  • A Comprehensive Review of Viscosupplementation in Osteoarthritis of the Knee
    Jacquelin Peck, Annabel Slovek, Paulo Miro, Neeraj Vij, Blake Traube, Christopher Lee, Amnon A. Berger, Hisham Kassem, Alan D. Kaye, William F. Sherman, Alaa Abd-Elsayed
    Orthopedic Reviews.2021;[Epub]     CrossRef
  • Polydeoxyribonucleotide Regulation of Inflammation
    Maria Teresa Colangelo, Carlo Galli, Stefano Guizzardi
    Advances in Wound Care.2020; 9(10): 576.     CrossRef
  • The efficacy and safety of polydeoxyribonucleotide for the treatment of knee osteoarthritis
    Man Soo Kim, Ryu Kyoung Cho, Yong In
    Medicine.2019; 98(39): e17386.     CrossRef
  • 18,335 View
  • 526 Download
  • 17 Web of Science
  • 24 Crossref
Does Adequate Lumbar Segmental Motion Reflect Recovery Process in Acute Lumbar Disc Herniation?
Hyuntae Kim, Ho Joong Jung, Minsun Kim, Seong-Eun Koh, In-Sik Lee
Ann Rehabil Med 2019;43(1):38-44.   Published online February 28, 2019
DOI: https://doi.org/10.5535/arm.2019.43.1.38
Objective
To investigate if the extent of lumbar segmental motion is correlated with the recovery process in the form of pain intensity in patients with acute single level lumbar disc herniation (LDH).
Methods
A retrospective review of medical records was performed on patients presented with acute low back pain from January 2011 to December 2017. With prerequisites of undergoing both lumbar spine magnetic resonance imaging and functional radiography, patients with etiologies other than single level LDH were excluded. A total of 46 patients were selected, including 27 patients with disc herniation at L4-5 level and 19 patients at L5-S1 level. Pearson correlation analysis of pain intensity against segmental range of motion (sROM) and percentage of sROM of each lumbar segment was performed at the initial evaluation point and follow-ups.
Results
Serial documentation of pain intensity and functional radiography exhibited an inverse correlation between changes in visual analogue scale (VAS) and sROM in single level LDH at L4-5 level (r=-0.69, p<0.05). In addition, percentage of sROM showed a negative correlation with pain intensity at the aforementioned segment (r=-0.74, p<0.05). Initial pain intensity was also inversely correlated to sROM of the affected segment (r=-0.83, p<0.01 at L4-5; r=-0.82, p<0.05 at L5-S1).
Conclusion
Improvement in sagittal mobility of the affected segment in LDH adequately reflected mitigation of low back pain during the recovery process. This conjunction could illustrate that the involved segment is overcoming natural immobilization, evidently demonstrating an inverse relationship between initial pain intensity and limitation of sagittal range of motion.

Citations

Citations to this article as recorded by  
  • Relationships and representations of brain structures, connectivity, dynamics and functions
    Oliver Schmitt
    Progress in Neuro-Psychopharmacology and Biological Psychiatry.2025; 138: 111332.     CrossRef
  • 6,507 View
  • 97 Download
  • 1 Crossref
Effect of Intra-articular Hyaluronic Acid Injection on Hemiplegic Shoulder Pain After Stroke
Myung Hun Jang, Chang-Hyung Lee, Yong-Il Shin, Soo-Yeon Kim, Sung Chul Huh
Ann Rehabil Med 2016;40(5):835-844.   Published online October 31, 2016
DOI: https://doi.org/10.5535/arm.2016.40.5.835
Objective

To evaluate the efficacy of intra-articular hyaluronic acid (IAHA) injection for hemiplegic shoulder pain (HSP) after stroke.

Methods

Thirty-one patients with HSP and limited range of motion (ROM) without spasticity of upper extremity were recruited. All subjects were randomly allocated to group A (n=15) for three weekly IAHA injection or group B (n=16) for a single intra-articular steroid (IAS) injection. All injections were administered by an expert physician until the 8th week using a posterior ultrasonography-guided approach. Shoulder joint pain was measured using the Wong-Baker Scale (WBS), while passive ROM was measured in the supine position by an expert physician.

Results

There were no significant intergroup differences in WBS or ROM at the 8th week. Improvements in forward flexion and external rotation were observed from the 4th week in the IAHA group and the 8th week in the IAS group. Subjects experienced a statistically significant improvement in pain from the 1st week in the IAS and from the 8th week in IAHA group, respectively.

Conclusion

IAHA seems to have a less potent ability to reduce movement pain compared to steroid in the early period. However, there was no statistically significant intergroup difference in WBS and ROM improvements at the 8th week. IAHA might be a good alternative to steroid for managing HSP when the use of steroid is limited.

Citations

Citations to this article as recorded by  
  • Efficacy of injection therapies in reducing hemiplegic shoulder pain: a systematic review and meta-analysis
    Jing Nie, Hang Zhou, Shenao Du, Haowei Zhang, Yiying Liu, Xiangyang Wei, Wenhua Ning, Haiming Wang
    Frontiers in Neurology.2025;[Epub]     CrossRef
  • Prevalence of Hemiplegic Shoulder Pain in Iran: A Systematic Review and Meta-analysis
    Aryoobarzan Rahmatian, Elham Bastani, Fariba Shokri, Ali Karbasfrushan
    Anesthesiology and Pain Medicine.2023;[Epub]     CrossRef
  • Effectiveness of Botulinum Toxin A in Treatment of Hemiplegic Shoulder Pain: A Systematic Review and Meta-analysis
    Hui-Min Xie, Ting-Ting Guo, Xuan Sun, Han-Xiao Ge, Xue-Dan Chen, Ke-Jia Zhao, Li-Ning Zhang
    Archives of Physical Medicine and Rehabilitation.2021; 102(9): 1775.     CrossRef
  • Comparative Effectiveness of Injection Therapies for Hemiplegic Shoulder Pain in Stroke: A Systematic Review and Network Meta-Analysis
    Yi-Hsiang Chiu, Ke-Vin Chang, Wei-Ting Wu, Po-Cheng Hsu, Levent Özçakar
    Pharmaceuticals.2021; 14(8): 788.     CrossRef
  • The Effect of Chuna Manual Therapy for Shoulder Pain in Hemiplegic Patients after Stroke: A Systematic Review and Meta-Analysis
    Eun-Mi Oh, Eun-Jung Lee
    Journal of Korean Medicine Rehabilitation.2020; 30(3): 89.     CrossRef
  • The effects of ultrasound-guided corticosteroid injection for the treatment of hemiplegic shoulder pain on depression and anxiety in patients with chronic stroke
    Min Cheol Chang
    International Journal of Neuroscience.2017; 127(11): 958.     CrossRef
  • The effectiveness of 2 consecutive intra-articular polydeoxyribonucleotide injections compared with intra-articular triamcinolone for hemiplegic shoulder pain
    Donghwi Park, Kwang Jae Yu, Ju Young Cho, Seung Beom Woo, Junu Park, Zeeihn Lee, Jong Min Kim
    Medicine.2017; 96(46): e8741.     CrossRef
  • Pathophysiology of adhesive capsulitis of shoulder and the physiological effects of hyaluronan
    Xiangnan Yuan, Zhiqiang Zhang, Jianjun Li
    European Journal of Inflammation.2017; 15(3): 239.     CrossRef
  • 8,948 View
  • 91 Download
  • 9 Web of Science
  • 8 Crossref
Objective

To evaluate the feasibility of a new position (internal rotation in hanging) in ultrasonography, we compared the length of the glenohumeral joint space and the effectiveness of steroid injection with the hanging position and with the commonly used abdomen or cross position.

Methods

A prospective, randomized controlled trial was performed in 42 patients with adhesive capsulitis of shoulder. We used three arm positions for the posterior approach as follows: the patient's palm on thigh, other hand on abdomen (abdomen position); hand on patient's opposite shoulder (cross position); arm in hanging position with internal rotation of shoulder (hanging position). The order of shoulder position was randomized and blinded. Real-time ultrasonography-guided intra-articular steroid injection was performed by posterior approach at the first position in each patient. The Brief Pain Inventory (BPI), the Shoulder Pain and Disability Index (SPADI), and range of motion (ROM) were measured before steroid injection and 2 weeks after injection.

Results

The lengths of the joint space were 2.88±0.75, 2.93±0.89, and 2.82±0.79 mm in abdomen, cross, and hanging position respectively, with no significant difference among the three positions (p=0.429). Treatment efficacy was significantly improved in ROM, total BPI, and SPADI in all three positions (p<0.001). The changes in ROM for shoulder abduction were 23.6°±19.7°, 22.2°±20.9°, and 10.0°±7.8° in abdomen, cross, and hanging position, respectively. Changes in total BPI scores were 25.1±15.7, 23.6.±18.0, 11.6±6.1, and changes in total SPADI score were 35.0±14.2, 30.9±28.9, and 16.5±10.3 in abdomen, cross, and hanging position, respectively. There were no significant difference among the three positions for all parameters (p=0.194, p=0.121, and p=0.108, respectively.

Conclusion

For patients with adhesive capsulitis who cannot achieve or maintain abdomen or cross position, scanning and injection with the shoulder in internal rotation with hanging position may be a useful alternative.

Citations

Citations to this article as recorded by  
  • Effects of Transcatheter Arterial Embolization for Chronic Intractable Shoulder Pain: A Prospective Clinical Study
    Kun Yung Kim, Young-Min Han, Myoung-Hwan Ko, Jeong-Hwan Seo, Sung-Hee Park, Yu Hui Won, Gi-Wook Kim, Tun-Chieh Chen
    International Journal of Clinical Practice.2025;[Epub]     CrossRef
  • Effect of Arm Position on Visualization of Target Zone for Posterior Glenohumeral Joint Injection
    James Kho, Ghassan Almeer, Christine Azzopardi, Ravneet Singh, Steven James, Rajesh Botchu
    Indian Journal of Musculoskeletal Radiology.2020; 2: 104.     CrossRef
  • Treatment of Adhesive Capsulitis of the Shoulder
    Lauren H. Redler, Elizabeth R. Dennis
    Journal of the American Academy of Orthopaedic Surgeons.2019; 27(12): e544.     CrossRef
  • 9,316 View
  • 109 Download
  • 2 Web of Science
  • 3 Crossref
Range of Motion of the Ankle According to Pushing Force, Gender and Knee Position
Kang Hee Cho, Yumi Jeon, Hyunkeun Lee
Ann Rehabil Med 2016;40(2):271-278.   Published online April 25, 2016
DOI: https://doi.org/10.5535/arm.2016.40.2.271
Objective

To investigate the difference of range of motion (ROM) of ankle according to pushing force, gender and knee position.

Methods

One hundred and twenty-eight healthy adults (55 men, 73 women) between the ages of 20 and 51, were included in the study. One examiner measured the passive range of motion (PROM) of ankle by Dualer IQ Inclinometers and Commander Muscle Testing. ROM of ankle dorsiflexion (DF) and plantarflexion (PF) according to change of pushing force and knee position were measured at prone position.

Results

There was significant correlation between ROM and pushing force, the more pushing force leads the more ROM at ankle DF and ankle PF. Knee flexion of 90° position showed low PF angle and high ankle DF angle, as compared to the at neutral position of knee joint. ROM of ankle DF for female was greater than for male, with no significant difference. ROM of ankle PF for female was greater than male regardless of the pushing force.

Conclusion

To our knowledge, this is the first study to assess the relationship between pushing force and ROM of ankle joint. There was significant correlation between ROM of ankle and pushing force. ROM of ankle PF for female estimated greater than male regardless of the pushing force and the number of measurement. The ROM of the ankle is measured differently according to the knee joint position. Pushing force, gender and knee joint position are required to be considered when measuring the ROM of ankle joint.

Citations

Citations to this article as recorded by  
  • Effects of cryotherapy on function, pain intensity, swelling, and dorsiflexion range of motion in acute ankle sprain: Protocol for the FROST randomised controlled trial
    Julio Miranda, Hytalo Jesus Silva, Fabiane Gontijo Correa, Rafaela Figueiredo, Gabriel Fonseca, Victor Guilherme Oliveira, Sérgio Samuel Borba Fonseca Silva, Samuel Pereira Santos, Itayano Mendes Lamas, Frederico Ataíde, Anderson Santons, Sérgio Antunes S
    PLOS One.2025; 20(6): e0325456.     CrossRef
  • Barriers to Enrollment in a Post-Stroke Neuromodulation and Walking Study: Implications for Recruiting Women
    Twinkle Mehta, Brice Cleland, Sangeetha Madhavan
    Neurorehabilitation and Neural Repair.2024; 38(3): 207.     CrossRef
  • The influence of gender and sport on popliteal angle and dorsiflexion in junior high school students
    Krzysztof Pietrzak, Artur Bania, Krzysztof Nowocień, Bartosz Kraszewski, Marzena Wiernicka
    BMC Musculoskeletal Disorders.2024;[Epub]     CrossRef
  • A New Method to Evaluate Joint Hypermobility in Paediatric Patients with Neurodevelopmental Disorders: A Preliminary Study
    Leonardo Zoccante, Marco Luigi Ciceri, Gianfranco Di Gennaro, Marco Zaffanello
    Children.2024; 11(9): 1150.     CrossRef
  • A User-Friendly Nonmotorized Device for Ankle Rehabilitation
    Rogério Sales Gonçalves, Lucas Antônio Oliveira Rodrigues, René Humbert, Giuseppe Carbone
    Robotics.2023; 12(2): 32.     CrossRef
  • Countermovement Jump Performance Is Related to Ankle Flexibility and Knee Extensors Torque in Female Adolescent Volleyball Athletes
    Vassilios Panoutsakopoulos, Eleni Bassa
    Journal of Functional Morphology and Kinesiology.2023; 8(2): 76.     CrossRef
  • Brain white matter correlates of learning ankle tracking using a wearable device: importance of the superior longitudinal fasciculus II
    Chishan Shiao, Pei-Fang Tang, Yu-Chen Wei, Wen-Yih Isaac Tseng, Ta-Te Lin
    Journal of NeuroEngineering and Rehabilitation.2022;[Epub]     CrossRef
  • Walking on a Vertically Oscillating Platform with Simulated Gait Asymmetry
    Mashaer Alyami, Jeff A. Nessler
    Symmetry.2021; 13(4): 555.     CrossRef
  • Bottom-Up Kinetic Chain in Drop Landing among University Athletes with Normal Dynamic Knee Valgus
    Nazatul Izzati Jamaludin, Farhah Nadhirah Aiman Sahabuddin, Raja Khairul Mustaqim Raja Ahmad Najib, Muhamad Lutfi Hanif Shamshul Bahari, Shazlin Shaharudin
    International Journal of Environmental Research and Public Health.2020; 17(12): 4418.     CrossRef
  • Normal active range of motion of lower extremity joints of the healthy young adults in Cairo, Egypt
    Shimaa T. Abu El Kasem, Sobhy M. Aly, Ehab M. Kamel, Hisham M. Hussein
    Bulletin of Faculty of Physical Therapy.2020;[Epub]     CrossRef
  • Determining the Reliability of a New Method for Measuring Joint Range of Motion Through a Randomized Controlled Trial
    So Young Ahn, Hanbit Ko, Jeong Oh Yoon, Sun Ung Cho, Jong Hyun Park, Kang Hee Cho
    Annals of Rehabilitation Medicine.2019; 43(6): 707.     CrossRef
  • Range of motion and ankle injury history association with sex in pediatric and adolescent athletes
    Dai Sugimoto, Ronald E. McCartney, Robert L. Parisien, Jesse Dashe, Dennis R. Borg, William P. Meehan
    The Physician and Sportsmedicine.2018; 46(1): 24.     CrossRef
  • 13,167 View
  • 113 Download
  • 15 Web of Science
  • 12 Crossref
Effects of Repeated Steroid Injection at Subacromial Bursa With Different Interval
Seung Deuk Byun, Yong Ho Hong, Sung Kyung Hong, Jin Won Song, Seung Beom Woo, Jae Hyun Noh, Jong Min Kim, Zee Ihn Lee
Ann Rehabil Med 2014;38(6):805-811.   Published online December 24, 2014
DOI: https://doi.org/10.5535/arm.2014.38.6.805
Objective

To evaluate the effects of repeated steroid injection at subacromial bursa with different interval for patient with periarticular shoulder disorder.

Methods

Group A (n=10) received subacromial bursa injection only on their first visit, group C (n=10) received the injection on their first visit and one week later, and group B (n=10) received the injection on their first visit and two weeks later. All injections were done with a combination of 40 mg (1.0 mL) of triamcinolone and 5.0 mL 0.5% lidocaine (6 mL total). We examined the active range of motion (AROM) of the shoulder joint, visual analogue scale (VAS), and shoulder disability questionnaire (SDQ) at baseline at 1, 2, and 4 weeks after the initial injection.

Results

In VAS, comparing the changes in VAS between groups, group B showed significant improvements compared with group A or C at 4 weeks after the initial injection (p<0.05). In SDQ, comparing the changes in SDQ between the groups, group B and C showed more improvement than group A at 4 weeks after the initial injection, but these results were not statistically significant (p>0.05). In AROM, comparing the changes in AROM of external rotation between groups, group B and C showed significant improvement compared with group A at 4 weeks after the initial injection (p<0.05).

Conclusion

It may be more effective in pain relief for patients with periarticular disorder to receive subacromial bursa injections twice with 2-week interval, as opposed to once.

Citations

Citations to this article as recorded by  
  • Role of Platelet Rich Plasma (PRP) injection in treatment of rotator cuff tear
    Nermin Hassan El Gharbawy, Hossam Salaheldin Labib
    Egyptian Rheumatology and Rehabilitation.2020;[Epub]     CrossRef
  • Ultrasound-guided injection of platelet rich plasma versus corticosteroid for treatment of rotator cuff tendinopathy: Effect on shoulder pain, disability, range of motion and ultrasonographic findings
    Doaa H. Ibrahim, Nagat M. El-Gazzar, Hanan M. El-Saadany, Radwa M. El-Khouly
    The Egyptian Rheumatologist.2019; 41(2): 157.     CrossRef
  • Efficacy of ultrasonography-guided intra-articular steroid injection of the shoulder and excercising in patients with adhesive capsulitis: Glenohumeral versus subacromial approaches
    Soha F. Khallaf, Mervat I. Hussein, Amal M. El-Barbary, Radwa M. El Khouly
    The Egyptian Rheumatologist.2018; 40(4): 277.     CrossRef
  • Early Clinical Outcomes after Subacromial Injection of Ketorolac in Patients with Shoulder Impingement Syndrome: A Comparison with Steroid Injection
    Jieun Kwon, Ye Hyun Lee, Hae Min Kim, Jong Min Kim, Hyun Suk Jung, Seung Rim Yi
    Journal of the Korean Orthopaedic Association.2017; 52(2): 170.     CrossRef
  • The Effectiveness of Ultrasound-guided Bee Venom Pharmacopuncture Combined with Integrative Korean Medical Treatment for Rotator cuff Diseases : A Retrospective Case Series※
    Jeong Kyo Jeong, Gi Nam Park, Kyung Min Kim, So Yun Kim, Eun Seok Kim, Jung Ho Kim, Seung Kyu Nam, Young Il Kim
    The Acupuncture.2016; 33(4): 165.     CrossRef
  • 6,077 View
  • 76 Download
  • 4 Web of Science
  • 5 Crossref
The Comparison of Effects of Suprascapular Nerve Block, Intra-articular Steroid Injection, and a Combination Therapy on Hemiplegic Shoulder Pain: Pilot Study
Woo Hyun Jeon, Gun Woong Park, Ho Joong Jeong, Young Joo Sim
Ann Rehabil Med 2014;38(2):167-173.   Published online April 29, 2014
DOI: https://doi.org/10.5535/arm.2014.38.2.167
Objective

To assess the relative effectiveness of three injections methods suprascapular nerve block (SSNB) alone, intra-articular steroid injection (IAI) alone, or both-on relief of hemiplegic shoulder pain.

Methods

We recruited 30 patients with hemiplegic shoulder pain after stroke. SSNB was performed in 10 patients, IAI in 10 patients, and a combination of two injections in 10 patients. All were ultrasonography guided. Each patient's maximum passive range of motion (ROM) in the shoulder was measured, and the pain intensity level was assessed with a visual analogue scale (VAS). Repeated measures were performed on pre-injection, and after injection at 1 hour, 1 week, and 1 month. Data were analyzed by Kruskal-Wallis and Friedman tests.

Results

All variables that were repeatedly measured showed significant differences in shoulder ROM with time (p<0.05), but there was no difference according injection method. In addition, VAS was statistically significantly different with time, but there was no difference by injection method. Pain significantly decreased until a week after injection, but pain after a month was relatively increased. However, pain was decreased compared to pre-injection.

Conclusion

The three injection methods significantly improved shoulder ROM and pain with time, but no statistically significant difference was found between them.

Citations

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  • Comparison of the efficacy of intramuscular botulinum toxin type-A injection into the pectoralis major and the teres major muscles and suprascapular nerve block for hemiplegic shoulder pain: a prospective, double-blind, randomized, controlled trial
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A Comparison of the Short-Term Effects of a Botulinum Toxin Type A and Triamcinolone Acetate Injection on Adhesive Capsulitis of the Shoulder
Young-Jin Joo, Se-Jin Yoon, Chang-Won Kim, Jung-Hwan Lee, Young-Jin Kim, Jung-Hoi Koo, Sun-Hong Song
Ann Rehabil Med 2013;37(2):208-214.   Published online April 30, 2013
DOI: https://doi.org/10.5535/arm.2013.37.2.208
Objective

To evaluate the short-term clinical effects of the intra-articular injection of botulinum toxin type A (BoNT-A) for the treatment of adhesive capsulitis.

Methods

A prospective, controlled trial compared the effects of intra-articular BoNT-A (Dysport; 200 IU, n=15) with the steroid triamcinolone acetate (TA; 20 mg, n=13) in patients suffering from adhesive capsulitis of the shoulder. All patients were evaluated using a Numeric Rating Scale (NRS) of the pain intensity and a measurement of the range of motion (ROM) at baseline (before treatment) and at 2, 4, and 8 weeks post-treatment.

Results

The NRS at 2 weeks (BoNT-A vs. TA; 5.0 vs. 5.2), 4 weeks (4.1 vs. 4.9) and 8 weeks (3.8 vs. 4.6) of both treatment groups were significantly lower than that measured at baseline (7.4 vs. 7.6). The ROM of patients' shoulders increased significantly from baseline in both treatment groups. There was no significant difference in the NRS of pain intensity or the ROM between the two groups. Reduction in the pain intensity score was maintained for 8 weeks post-injection in both groups. There were no significant adverse events in either treatment group.

Conclusion

The results suggest that there are no significant short-term differences between the intra-articular injections of BoNT-A and TA. Although BoNT-A has a high cost, it may be used as a safe alternative of TA to avoid the steroid-induced side effects or as a second-line agent, for patients who have failed to respond to the current treatments.

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    Mathieu Gagnière, Camille Daste, Raphaël Campagna, Jean-Luc Drapé, Antoine Feydy, Henri Guerini, Marie-Martine Lefèvre-Colau, François Rannou, Christelle Nguyen
    Annals of Physical and Rehabilitation Medicine.2025; 68(1): 101877.     CrossRef
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    Jung Hwan Lee, Jun Ho Lee, Min Cheol Chang
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    Peng Zheng, Yu Shi, Hang Qu, Meng lin Han, Zhi qiang Wang, Qing Zeng, Manxu Zheng, Tao Fan
    Trials.2024;[Epub]     CrossRef
  • Cytokines' Role in the Pathogenesis and Their Targeting for the Prevention of Frozen Shoulder: A Narrative Review
    Ahmed Alghamdi, Ali H Alyami, Raad M. M Althaqafi, Ahmed Alzeyadi, Faisal S Alrubaei, Almuhanad A Alyami , Mohamed S Singer, Abdulelah A Saati , Wasn T Alotaibi , Maha O Alsharif
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  • Frozen shoulder
    Neal L. Millar, Adam Meakins, Filip Struyf, Elaine Willmore, Abigail L. Campbell, Paul D. Kirwan, Moeed Akbar, Laura Moore, Jonathan C. Ronquillo, George A. C. Murrell, Scott A. Rodeo
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    Nicole Blanshan, Hollis Krug
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    Ke-Vin Chang, Yi-Hsiang Chiu, Wei-Ting Wu, Po-Cheng Hsu, Levent Özçakar
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    Giulia Bellon, Andrea Venturin, Stefano Masiero, Alessandra Del Felice
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    Mathilde Courseau, Pascale Vergne Salle, Danièle Ranoux, Anais de Pouilly Lachatre
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    Helka M. Heikkilä, Tarja S. Jokinen, Pernilla Syrjä, Jouni Junnila, Anna Hielm-Björkman, Outi Laitinen-Vapaavuori, Louis S Premkumar
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Efficacy of Ultrasonography-Guided Injections in Patients with Facet Syndrome of the Low Lumbar Spine
Dong Hwan Yun, Hee-Sang Kim, Seung Don Yoo, Dong Hwan Kim, Jinn Man Chon, Seong He Choi, Dae Gyu Hwang, Pil Kyo Jung
Ann Rehabil Med 2012;36(1):66-71.   Published online February 29, 2012
DOI: https://doi.org/10.5535/arm.2012.36.1.66
Objective

To investigate the efficacy of ultrasonography (US)-guided injections in patients with low lumbar facet syndrome, compared with that in patients who received fluoroscopy (FS)-guided injections.

Method

Fifty-seven subjects with facet syndrome of the lumbar spine of the L4-5 and L5-S1 levels were randomly divided into two groups to receive intraarticular injections into the facet joint. One group received FS-guided facet joint injections and the other group received US-guided facet joint injections. Treatment effectiveness was assessed using a visual analogue scale (VAS), physician's and patient's global assessment (PhyGA, PaGA), and the modified Oswestry Disability Index (MODI). All parameters were evaluated four times: before injections, and at a week, a month, and three months after injections. We also measured, in both groups, how long it took to complete the whole procedure.

Results

Each group showed significant improvement from the facet joint injections on the VAS, PhyGA, PaGA, and MODI (p<0.05). However at a week, a month, and three months after injections, no significant differences were observed between the groups with regard to VAS, PhyGA, PaGA, and MODI (p>0.05). Statistically significant differences in procedure time were observed between groups (FS: 248.7±6.5 sec; US: 263.4±5.9 sec; p=0.023).

Conclusion

US-guided injections in patients with lumbar facet syndrome are as effective as FS-guided injections for pain relief and improving activities of daily living.

Citations

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  • 69 Download
  • 32 Crossref
Subacromial Bursa Injection of Hyaluronate with Steroid in Patients with Peri-articular Shoulder Disorders
Seung Deuk Byun, Dong Hwi Park, Won Duck Choi, Zee Ihn Lee
Ann Rehabil Med 2011;35(5):664-672.   Published online October 31, 2011
DOI: https://doi.org/10.5535/arm.2011.35.5.664
Objective

To investigate the additive effect of sono-guided subacromial bursa injection of hyaluronate with steroid in patients with peri-articular shoulder disorders.

Method

This prospective randomized controlled trial involved 26 patients who had shoulder pain. Group A, consisting of 13 patients, was treated with a sono-guided subacromial bursa injection containing a mixture of 0.5% lidocaine (5 ml) and triamcinolone 40 mg (1 ml), followed by injection with sodium hyaluronate (2 ml) once a week for 3 weeks. The other 13 patients (Group B) were treated with a sono-guided subacromial bursa injection containing a mixture of 0.5% lidocaine (5 ml) and triamcinolone 40 mg (1 ml) once a week for 3 weeks. The effects were assessed using a visual analogue scale (VAS) of shoulder pain, active range of motion (AROM), shoulder function assessment scale (SFA), shoulder disability questionnaire (SDQ) at study entry and every week from first injection until 4 weeks after the 1st injection (= 2 weeks after 3rd injection).

Results

(1) Demographic features and all parameters measured before injection did not show a significant difference between the 2 groups. (2) Statistically significant improvements were shown in VAS, SFA, SDQ during the 1st, 2nd, and 4th week after the first injection in both groups (p<0.05). (3) SFA showed significant improvement at 1 week after injection only in group A (p<0.05). (4) AROM of internal rotation showed significant improvement at week 4 after the 1st injection only in group A (p<0.05).

Conclusion

Subacromial bursa injection of hyaluronate with steroid in patients with peri-articular shoulder disorders has additive effects on functional improvement of the affected shoulder, including the AROM of internal rotation.

Citations

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  • Comparison of three common shoulder injections for rotator cuff tears: a systematic review and network meta-analysis
    Xinzhao Jiang, Hong Zhang, Qing Wu, Yun Chen, Tian Jiang
    Journal of Orthopaedic Surgery and Research.2023;[Epub]     CrossRef
  • Efficacy of hyaluronic acid in rotator cuff pathology compared to other available treatment modalities: A Systematic Review and meta-analysis
    Shivam Bansal, Balgovind S. Raja, Bishwa Bandhu Niraula, Anil Regmi, Arghya Kundu Choudhury, Divyansh Sharma, Mohit Dhingra
    Journal of Orthopaedic Reports.2023; 2(3): 100157.     CrossRef
  • Comparison of single platelet-rich plasma injection with hyaluronic acid injection for partial-thickness rotator cuff tears
    Shou-Hsien Huang, Po-Cheng Hsu, Kevin A. Wang, Chen-Liang Chou, Jia-Chi Wang
    Journal of the Chinese Medical Association.2022; 85(6): 723.     CrossRef
  • Cross-Linked Hyaluronate and Corticosteroid Combination Ameliorate the Rat Experimental Tendinopathy through Anti-Senescent and -Apoptotic Effects
    Po-Yen Ko, Che-Chia Hsu, Shih-Yao Chen, Li-Chieh Kuo, Wei-Ren Su, I-Ming Jou, Fong-Chin Su, Po-Ting Wu
    International Journal of Molecular Sciences.2022; 23(17): 9760.     CrossRef
  • Transcranial direct current stimulation (a-tCDS) after subacromial injections in patients with subacromial pain syndrome: a randomized controlled pilot study
    Samuel Larrivée, Frédéric Balg, Guillaume Léonard, Sonia Bédard, Michel Tousignant, Patrick Boissy
    BMC Musculoskeletal Disorders.2021;[Epub]     CrossRef
  • Acromioclavicular osteoarthritis and shoulder pain: a review of the role of ultrasonography
    Matteo Precerutti, Manuela Formica, Mara Bonardi, Caterina Peroni, Francesco Calciati
    Journal of Ultrasound.2020; 23(3): 317.     CrossRef
  • The effectiveness of 2 consecutive intra-articular polydeoxyribonucleotide injections compared with intra-articular triamcinolone for hemiplegic shoulder pain
    Donghwi Park, Kwang Jae Yu, Ju Young Cho, Seung Beom Woo, Junu Park, Zeeihn Lee, Jong Min Kim
    Medicine.2017; 96(46): e8741.     CrossRef
  • Le rilonacept dans le traitement de la bursite sous-acromiale : étude ouverte randomisée de non-infériorité contre l’acétonide de triamcinolone
    Matthew B. Carroll, Spencer A. Motley, Susanna Wohlford, Bryan C. Ramsey
    Revue du Rhumatisme.2016; 83(5): 377.     CrossRef
  • Rilonacept in the treatment of subacromial bursitis: A randomized, non-inferiority, unblinded study versus triamcinolone acetonide
    Matthew B. Carroll, Spencer A. Motley, Susanna Wohlford, Bryan C. Ramsey
    Joint Bone Spine.2015; 82(6): 446.     CrossRef
  • Suprascapular Nerve Block versus Intra-articular Hyaluronic Acid Injection in Hemiplegic Shoulder Pain
    Sang-Hyun Kim, Dong Suk Kim
    Brain & Neurorehabilitation.2014; 7(2): 118.     CrossRef
  • Effects of Subacromial Bursa Injection With Corticosteroid and Hyaluronidase According to Dosage
    Won Duck Choi, Dong Hyun Cho, Yong Ho Hong, Jae Hyun Noh, Zee Ihn Lee, Seung Deuk Byun
    Annals of Rehabilitation Medicine.2013; 37(5): 668.     CrossRef
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Ultrasonography Guided Glenohumeral Injection Using an Anterior Approach: A Cadaveric Study.
Kim, Min Wook , Kim, Joon Sung , Ko, Young Jin , Lee, Won Ihl , Kim, Jae Min , Yun, Jong Soo
J Korean Acad Rehabil Med 2009;33(2):215-218.
Objective
To assess the accuracy and confidence of the glenohumeral joint injection using an anterior approach in cadavers. Method: Eight shoulders from six cadavers were placed supine with arm abduction and external rotation. A single physiatrist performed all the ultrasonography guided injection using an anterior approach. A twenty-one gauge needle was placed into shoulder and intraarticular position was verified by small injection of blue dye. And then the anatomic dis-section was done. Results: Seven out of eight (87.5%) were judged to be accu-rately placed by the anatomic section. In one case, the needle tip was placed in supraglenoid space. In one of the seven accurate cases, the needle traversed the long head tendon of biceps muscle. Confidence of the injections was 87.5%. Conclusion: Ultrasonography guided glenohumeral injection using an anterior approach was efficient and safe. (J Korean Acad Rehab Med 2009; 33: 215-218)
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Biomechanical Evaluation of the Capsular Stiffness and Clinical Features in Adhesive Capsulitis of Shoulders.
Kim, Keewon , Kim, Tae Uk , Leigh, Ja Ho , Lee, Kyu Jin , Kim, Hee Chan , Chung, Sun Gun
J Korean Acad Rehabil Med 2009;33(2):205-214.
Objective
To evaluate the capsular stiffness of the gleno-humeral joint by measuring the slope of pressure- volume curves generated during intra-articular hydraulic distension (IHD) and analyze its correlation with clinical variables and outcomes in terms of limitation of range of motion (LOM) and severity of pain. Method: IHD with real-time intra-articular pressure mo-nitoring was performed for 53 patients with adhesive capsulitis and the capsular stiffness was measured from pressure-volume curves by calculating the slope of elastic deformation region. LOM, measured by LOM score and sum of ROMs (range of motion), and degree of pain, measured by visual analog scale (VAS), were evaluated before and after IHD: three days (3D) and one month (1M) after IHD. Results: In patients with stiffer capsules, LOM and pain were severe before IHD (Pearson's correlation coefficient (r)= 0.291, -0.348, 0.381 and p=0.065, 0.026, 0.014 for LOM score, sum of ROMs and VAS, respectively. By this order, henceforth). On 3D follow up, the correlation between the stiffness and LOM or pain was maintained (r=0.291, -0.348, 0.381 and p=0.065, 0.026, 0.014). The improvement of LOM score on 3D follow up was less as the capsules were stiffer (r=-0.368, p=0.023). On 1M follow up, LOM remained severer in stiffer capsules whereas pain did not (r=0.372, -0.402, 0.183 and p=0.039, 0.025, 0.342). Conclusion: The stiffness of the glenohumeral joint capsule, measured from the slope of pressure-volume curves during IHD, showed significant correlation with the severity of LOM and pain in patients with adhesive capsulitis of shoulder. (J Korean Acad Rehab Med 2009; 33: 205-214)
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Reference Values of Normal Femoral Condylar Cartilage Thickness and Its Ultrasonographic Findings.
Kim, Hye Won , Lee, Jong In , Ko, Young Jin , Lim, Ji Eun , Lee, Jin Young , Lee, Sang Jee
J Korean Acad Rehabil Med 2008;32(6):703-710.
Objective: To establish reference values for the femoral condylar cartilage thickness and to observe the cartilage clarity and sharpness between different age groups of healthy Koreans employing a ultrasonographic scanner. Method: 105 healthy volunteers from the ages of twenties to the fifties, without clinical signs of osteoarthritis were recruited for the study. Cartilage thickness at both intercondylar notch, medial condylar and lateral condylar area were obtained with 12 MHz linear transducer, in supine position under maximum flexion of the knee joints. Cartilage sharpness and clarity were also recorded in grade between 0 to 3. Results: The thickness of cartilage significantly decreased with the increment of age (p<0.05) and the cartilage of the man was much thicker than woman (p=0.000). Grade of the sharpness and clarity was not different between age groups and the checked grade was mostly grade 1 and there was no grade 3. Conclusion: This study defines standard reference values of femoral condylar cartilage for musculoskeletal ultrasonography to prevent misinterpretation of thinning of cartilage thickness in difference age groups and sex. With these findings, we can specify the range of normal degenerative change of femoral condylar cartilage. (J Korean Acad Rehab Med 2008; 32: 703-710)
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The Additional Effect of Tear after Passive Exercise during Distension Arthrography in Patients with Frozen Shoulder.
Kim, Joon Sung , Kwon, Jeong Yi , Lee, Won Ihl , Kim, Jae Min
J Korean Acad Rehabil Med 2008;32(3):324-326.
Objective
To evaluate the effect of tear after passive ROM exercise during distension arthrography in patients with frozen shoulder. Method: Fifteen patients (male: 7, female: 8, mean 57.5 years old) who had complained of shoulder pain with decreased ROM at least 3 months prior were enrolled. Distension arthrogrphy of 35 ml of fluid which contained 10 ml of 1% lidocaine, 1 ml of depomedrol (40 mg), 19 ml of normal saline, and 5 ml of radiocontrast material was injected by a single physician. Then if there was no capsular tear, passive ROM exercise was performed for two minutes. Results: In seven of the thirteen patients, the occurrence of capsular tear was observed after only distension arthrography. In five of the six patients without capsular rupture, the occurrence of capsular tear was observed by passive ROM exercise after distension arthrography. Two patients were interrupted because of severe pain. Clinical outcomes of occurrence of capsular tear by conventional distension arthrography and by passive ROM exercise after distension arthrography were similar. Conclusion: Passive ROM exercise after distension arthrography could serve as an effective method of capsular tear in patients with frozen shoulder. (J Korean Acad Rehab Med 2008; 32: 324-326)
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Clinical Efficacy of Quantitative Bone Scintigraphy in Shoulder Adhesive Capsulitis.
Lee, Yong Taek , Park, Jung Mi , Chung, Seung Hyun
J Korean Acad Rehabil Med 2007;31(6):735-741.
Objective
To evaluate the clinical efficacy of the quantitative bone scintigraphy in shoulder adhesive capsulitis (AC). Method: Twenty-six AC patients and age-matched 18 healthy controls underwent bone scintigraphy. For the quantitative analysis, region of interest (ROI) was drawn over each gleno-humeral joint area, excluding coracoid process, acromion and acromio-clavicular joint. We obtained the uptake ratios of affected side to unaffected side from anterior and posterior image respectively. Additionally, mean uptake ratios were calculated from both anterior and posterior ROI count. Reference values for each uptake ratio were obtained from 18 healthy controls. Clinical stages of the patients were determined according to the history and physical examination including range of motion under sonographically guided intra-articular anesthesia (Hannafin's stage). Quantitative measurements were analyzed according to Hannafin's stage and clinical findings. Results: Uptake ratios for the patients were significantly higher than the controls (p<0.05). Sensitivities of the anterior image and mean uptake ratio were 81 % and 62% respectively. All 7 patients with abnormal findings in posterior image were stage II. Ninety-four percent in stage I and II showed abnormal mean uptake ratio. Nocturnal pain was associated with increased uptake ratio, particularly mean uptake ratio (p<0.05).Conclusion: The findings of quantitative bone scintigraphy correlated with the clinical diagnosis, nocturnal pain and Hannafin's stage. Thus, the quantitative bone scintigraphy may be helpful in the diagnosis of shoulder AC. Additionally, mean uptake ratio and posterior image may contribute to clinical staging of AC (i.e. stage I, II and stage II respectively). (J Korean Acad Rehab Med 2007; 31: 735-741)
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Case Report

Tuberculous Sacroiliitis.
Kim, Eun Jin , Shin, Ju Yon , Lee, Do Kyung
J Korean Acad Rehabil Med 2007;31(5):606-608.
Tuberculosis can affect the sacroiliac joint. The involvement has been reported in up to 10 percent of patients with osteoarticular tuberculosis. The onset is usually insidious, and early diagnosis requires a high index of clinical suspicion. Lack of awareness of this presently uncommon form of infection often leads to diagnostic delay and increased morbidity. Early diagnosis and proper treatment with anti-tuberculous medication could obtain a satisfactory functional outcome. We report a case of tuberculous sacroiliitis in a 21 year-old male patient including his clinical presentation, radiographic features and outcome of medical treatment. (J Korean Acad Rehab Med 2007; 31: 606-608)
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Original Articles

The Effects of Hyperosmolar Dextrose and Autologous Serum Injection in the Experimental Articular Defect of Rabbit.
Kim, Soo A , Kim, Eui Han , Kim, Sang Yun , Lee, Sung Yong , Yoon, Jae Nam , Lee, Yang Kyun
J Korean Acad Rehabil Med 2006;30(2):173-178.
Objective
Although the clinical effects of prolotherapy on osteoarthritis has been reported, there have been few previous studies showing the effects as a proliferant on articular cartilage. Also the autologous blood has been reported to used as a growth factor stimulant recently, we were trying to use dextrose and autologous serum for tissue regeneration respectively and evaluated the proliferative effect of autologous serum comparing with that of dextrose. Method: Twenty four rabbits were used for this study. The rabbits were divided into three groups. Group A did not get any special treatment. Group B was treated with 10% dextrose and group C with autologous serum. Six weeks la-ter, gross appearance and histologic findings were evaluated. Results: After sacrifice, the gross inspection of the knee joints revealed that group B and C were filled with the translucent tissue in defective cartilage. Group A still had defective cartilage. Histologic evaluation revealed increase of cellularity in the defect of the injected specimens when compared with the control. There was no morphological difference between group B and C. Conclusion: The repair process of the articular cartilage defects using dextrose and autologous serum were shown to be more effective than that of control group. (J Korean Acad Rehab Med 2006; 30: 173-178)
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Comparison of Blind Technique and Ultrasonography Guided Technique of Intraarticular Injection of the Shoulder.
Yi, Tae Im , Kim, Seung Taek , Kim, Dae Hwan , Kim, Joo Sup , Park, Jun Sung , Lee, Jae Hwan
J Korean Acad Rehabil Med 2006;30(1):45-50.
Objective
To evaluate the accuracy of ultrasonography (US) guided intraarticular injection technique comparing to blind technique of the shoulder joint. Method: Thirty patients with hemiplegia clinically diagnosed as adhesive capsulitis of the shoulder joint were included. Each patient was treated with serial intraarticular injections with both blind and US guided technique, and then was confirmed by X-ray. We analyzed possible factor including range of motion of the shoulder joint, degree of shoulder subluxation, and clinical stage by Cyriax contributing to failure of intraarticular injection with blind technique. Results: The accuracy of intraarticular injection using blind technique were 46.7% and 33.3% in each physician without significant interpersonal difference. However, US guided intraarticular injection showed the accuracy of 93.3%, significantly higher than blind technique (p<0.05). We could not find significant differences in clinical stage by Cyriax, degree of subluxation between success and failure group by blind technique. However, the range of external and internal rotation of the shoulder joint was more limited in failure group by blind technique (p<0.05). Conclusion: Ultrasonography guided injection into the shoulder joint improved the accuracy of injection without exposure to radiation and could be used as one of the promising treatment for patients with adhesive capsulitis of the shoulder. (J Korean Acad Rehab Med 2006; 30: 45-50)
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The Effect of Intra-articular Hyaluronic Acid in Facet Syndrome of the Lumbar Spine.
Kim, Hee Sang , Ahn, Kyung Hoi , Lee, Jong Ha , Kim, Dong Hwan , Kim, Min Jung , Kim, Hak Jun , Jeong, Yong Seol
J Korean Acad Rehabil Med 2005;29(5):489-494.
Objective
To evaluate the efficacy of intra-articular hyaluronic acid injection and to compare this with the efficacy of steroid injection for the treatment of facet syndrome of the lumbar spine. Method: Sixty-eight patients with facet syndrome of the lumbar spine were assigned two groups at random to receive an intra-articular injection into the facet joint. One group received a intra-articular injection of the facet joint three times at 1 week apart with a mixture of hyaluronic acid 0.6∼0.7 ml and 1% lidocaine 0.2 ml. The other group received a intra-articular injection of the facet joint one time with a mixture of triamcinolone 10 mg and 1% lidocaine 0.5∼1 ml. The effectiveness of treatment was assessed with the visual analogue scale (VAS), and the patient's life activities were assessed with the modified Oswestry questionnaire. Results: The VAS and the patient's life activity of the two groups all showed improvement at 1 week, 1 month and 3 months after injection, but there was no significant difference in the VAS scores and the patient's life activity scores between the two groups. Conclusion: The intra-articular injection of hyaluronic acid would be a good treatment method for facet syndrome of the lumbar spine. (J Korean Acad Rehab Med 2005; 29: 489-494)
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Changes of Intraarticular Temperature in the Knee Joint according to the Application Method of Cold Jet-stream.
Kim, Tai Kon , Wang, Jun Keuk , Choi, Ki Seob , Park, Si Bog
J Korean Acad Rehabil Med 2005;29(4):413-418.
Objective
To investigate the changes of intraarticular temperature in the knee according to the application methods of cold jet-stream and to find the more effective method which reduces the intraarticular temperature. Method: Fifteen healthy subjects were examined. We recorded both skin and intraarticular temperature of the knee for 120 minutes. We compared two different cooling methods using ⁣30oC cold jet-stream by CRAis (Century, Korea). The first was the intermittent cold jet-stream application method (ICA) which applied cold jet-stream to the knee joint every other minute for 5 minutes and the second was the continuous cold jet-stream application method with infrared (CCAI) for 5 minutes. Results: In ICA, the intraarticular temperature maximally dropped as 1.7⁑0.6oC (p<0.01) and it took 28.7⁑18.9 minutes. Intraarticular temperature dropped 0.6⁑0.5oC after 2 hour (p<0.05). In CCAI, the intraarticular temperature maximally dropped as 2.8⁑0.7oC (p<0.01) and it took 38.0⁑24.6 minutes, intraarticular temperature after 2 hour dropped as 1.36⁑0.75oC (p<0.05). According to the two methods, CCAI showed more reduction in the lowest and after 2 hour intraarticular temperature compared with ICA in the knee joint (p<0.05). Conclusion: CCAI is better for reducing the intraarticular temperature than ICA. (J Korean Acad Rehab Med 2005; 29: 413-418)
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The Response of the Injured Articular Cartilage of Rabbit Knee after Injection of Autologous Blood.
Kim, Soo A , Kim, Eui Han , Kim, Jin Il , Jang, Il , Lee, Ji Soo , Lee, Yang Kyun
J Korean Acad Rehabil Med 2005;29(4):406-412.
Objective
To evaluate the effects of proliferant by injecting blood into the articular cartilage defect. Method: The patella of rabbits were dislocated laterally and 2 mm circular and 2 mm depth full-thickness defect was made in the articular cartilage. We injected 0.2 cc autologous blood to the right defect and normal saline to the left one at 1 week after operation for six times with a 1 week interval. After injection for six weeks, the articular cartilage defect were obtained and stained with H-E and S-100. Results: The surface of the saline-injected group was easily distinguishable from the surrounding articular cartilage. But the blood-injected group had similar appearance to the surrounding cartilage, with the margin of the defect barely discerptible. Strong S-100 stained immune cartilage cells were observed in the blood-injected group. Conclusion: The repairing process of the injured articular cartilage using autologous blood was shown to be much better than that of saline-injected group although the observation period was short and the number of animal was small. So we found that autologous blood effectively repaired osteochondral defects. (J Korean Acad Rehab Med 2005; 29: 406-412)
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Case Report

Severe Adverse Effect after Intra-articular Injection of Hyaluronate in Osteoarthritis: A case report.
Kim, Soo A , Lee, Sung Yong , Lee, Kyung Hoon , Lee, Sang Oh , Yoon, Soo Yon , Son, Cheol Ho
J Korean Acad Rehabil Med 2004;28(1):109-112.
Osteoarthritis of the knee is a common cause of disability in the aging population. Traditional nonoperative treatment options include exercise, physical therapy, weight reduction, nonsteroidal antiinflammatory drugs, analgesics and corticosteroid injection. In recent years, intra-articular injection of hyaluronate-derived products has gained popularity as a palliative modality for the treatment of osteoarthritis of the knee. The common adverse reaction are mild pain or swelling at the site of injection that may occur up to 20% of patients. Severe local inflammation, warmth and joint effusion are rare and no systemic complication have been reported, to our knowledge. We presented one case in which synovial inflammation was observed following intra- articular injection of the knee. (J Korean Acad Rehab Med 2004; 28: 109-112)
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Original Articles
Effect of Periarticular Injection on Knee Pain in Patients with Knee Osteoarthritis.
Kim, Chul Hyun
J Korean Acad Rehabil Med 2002;26(2):198-202.

Objective: To evaluate the effects of a new periarticular injection in the patients with knee osteoarthritis.

Method: Twenty seven patients, who had knee pain, were met criteria of knee osteoarthritis of American Rheumatology Association. Two injection sites were used: one to infrapatellar fat pad and the other to near the insertion area of popliteus. At first, 1 cc of 0.5% lidocaine was injected to both sites. If pain was not releaved above 50%, a mixture of 1 cc of 0.5% lidocaine and 10 mg of triamcinolone acetonide was injected to twenty seven patients, 46 knees. All patients were evaluated visual analogue scale (VAS), time for 10 meter walking, time for stair up and down, isometric knee strength before and after

treatment. Paired student t test was done to investigate statistical significance of change of pain and function.

Results: Before treatment VAS, time for 10 meter walking, time for stair up and down and isometric knee strength were 6.1⁑2.1, 10.4⁑3.6, 10.8⁑7.1 and 34.0⁑11.4 respectively. After last treatment VAS, time for 10 meter walking, time for stair up and down and isometric knee strength were 3.5⁑2.5, 8.3⁑1.7, 8.2⁑3.6 and 38.8⁑12.9 respectively. The difference was stastistically significant between before and after treatment (p<0.05).

Conclusion: The new periarticular injection is useful in treatment of patients with knee osteoarthritis. (J Korean Acad Rehab Med 2002; 26: 198-202)

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Objective: To compare intraarticular steroid injection with and without capsular distension in the treatment of adhesive capsulitis of the shoulder

Method: Fifty-five cases those were clinically diagnosed as adhesive capsulitis of the shoulder were randomly assigned to one of two treatment groups. 28 cases were treated by intraarticular steroid injection with capsular distension (group 1) and 27 cases by steroid injection alone (group 2). They were evaluated by visual analogue scales, Cyriax stages of arthritis, and active shoulder range of motion (flexion, abduction, external rotation and internal rotation). Follow up assessments were made one week and one month after injection.

Results: There were no statistically significant differences in Cyriax stages and VAS between two groups. But in the group 1, shoulder range of motion showed significant improvement in flexion and internal rotation at one week, and flexion at one month.

Conclusion: Intraarticular steroid injection with cspsular distension had no advantage over steroid injection alone in pain reduction, but can help the patients to achieve better range of motion, especially flexion and internal rotation, in treatment of adhesive capsulitis of the shoulder.

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The Effect of Intra-articular Hyaluronic Acid and Steroid Injection in Osteoarthritis of the Knee.
Kim, Sang Beom , Yoon, Kisung , Park, Hee Seok , Kwak, Hyun , Ha, Nam Jin , Park, Jae Sung
J Korean Acad Rehabil Med 2000;24(4):747-755.

Objective: To evaluate the efficacy of intra-articular hyaluronic acid and steroid injection in osteoarthritis of the knee.

Method: Among 653 patients with osteoarthritis, 531 patients were participated in this study. They were divided to three groups; A, treated with hyaluronic acid 2.5 ml intra-articular injection once a week for 5 times; B, hyaluronic acid 2.5 ml once a week for 5 times with triamcinolone 20 mg once at the first time; C, only triamcinolone 20 mg at the first time. Before injection, X-ray with standing view were checked and divided according to Kellgren's grade of osteoarthritis. The amount of pain relief was assessed by pain rating score (PRS) and visual analogue scale (VAS) 1 week before and 1 month after the treatment.

Results: The degree of pain relief by PRS and VAS were all improved at 1 month after injection compared with pre-injection status (p<0.001). Intra-articular hyaluronic acid injection was more effective in Kellgren's grade I, II than in III, IV in pain relief and hyaluronic acid with steroid injection was more effective in III, IV.

Conclusion: The results suggest that intra-articular hyaluronic acid injection would be effective for the treatment of patients with osteoarthritis.

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Evaluation of the Efficacy of Sodium Hyaluronate to Degerative Osteoarthritis of the Knee.
Ko, Jae Young , Yun, Suk Bong , So, En Ha , Cho, En Su
J Korean Acad Rehabil Med 1999;23(4):842-847.

Objective: To obtain a effect of intraarticular injection of Sodium Hyaluronate in the patient with degenerative osteoarthritis without restriction of activities of daily living.

Method: Twenty-five patients were participated in this study. These patients are diagnosed as degenerative osteoarthritis by clinical symtoms and radiographic findings. Sodium hyaluronate, 2.5 ml, 3 mg/ampule, were injected intraarticulary without local anesthesia once a week for 5 times consecutively. For evaluation of the effectiveness of sodium hyaluronate, we assess the parameters for subjective and objective symtoms scored from 0 to 3 on 3 items, and for activities of daily living scored from 0 to 4 on 4 items. And then, we compared these data between pre-injection and at post-injection 2, 4, and 5 weeks. Changes of subjective and objective symtoms, and activities of daily living are assessed using Kellgren's X-ray grading of degenerative osteoarthritis. Improvement of the subjective pain is recorded by visual analogue scale.

Results: 1. Subjective and objective symtoms, and activities of daily living with time progression were significantly increased at post-injection 4, 5 weeks compared with pre-injection status (P<0.05). 2. Subjective and objective symtoms, and activities of daily living according to Kellgren's X-ray classification were significantly increased at stage II and III (P<0.05). 3. Visual analogue scale is significantly decreased after injection (P<0.05).

Conclusion: Intraarticular injection of sodium hyaluronate showed improvement of patient's subjective and objective symtoms, and activities of daily living. The improvement was pronounced in the cases of high grade of degenerative osteoarthritis (stage II, III) according to Kellgren's X-ray classification as well as low grade (Stage I).

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Effects of Intra-Articular Injection and Subscapularis Motor Point Block on Painful Hemiplegic Shoulder.
Kim, Eun Guk , So, Seung Wook , Kim, Hee Sang , Ahn, Kyung Hoi
J Korean Acad Rehabil Med 1999;23(3):615-621.

Objective: To evaluate the effects of intra-articular injection of shoulder and subscapularis motor point block on painful hemiplegic shoulder.

Method: Thirty painful hemiplegic shoulder of recent onset stroke were divided randomly into three groups, i.e. group I: range of motion (ROM) exercise only, group II: intra-articular injection with ROM exercise, group III: subscapularis motor point block with ROM exercise. The intra-articular injection of shoulder was done with 20 ml of normal saline, 5 ml of 1% lidocaine, and 40 mg of triamcinolone. The subscapularis motor point block was done with 5 ml of 5% phenol under electromyographic guide. The ROM in external rotation and simple X-ray of shoulder in full abduction were checked in three groups at pre-treatment and post-treatment 3 week, and the glenohumeral abduction and scapulohumeral rhythm were obtained from the shoulder X-ray.

Results: There were significant (p<0.05) improvements of glenohumeral abduction, external rotation, and scapulohumeral rhythm of shoulder in group II and III, but improvement of only glenohumeral abduction was significant in group I. Angular increment of glenohumeral abduction and external rotation was most significant in group III compared with other two groups.

Conclusion: These results suggest that the intra-articular injection of shoulder and subscapularis motor point block are potentially useful techniques in the prevention and management of the painful hemiplegic shoulder.

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The Effect of Intra-articular Steroid Injection for Adhesive Capsulitis in Spinal Cord Injured Patients.
Kim, Beom Joon , Lee, Bum Suk , Im, Min Sik , Hong, Byung Jin , Kim, Byung Sik
J Korean Acad Rehabil Med 1999;23(2):358-364.

Objective: The purpose of this study was to investigate the risk factors of adhesive capsulitis and the effect of intra-articular steroid injection in spinal cord injured patients.

Method: Fifty spinal cord injured patients participated in this study. The risk factors of adhesive capsulitis were compared between fourteen patients with adhesive capsulitis and thirty-six patients without one. Methylprednisolone acetate 40 mg mixed with 0.5% lidocaine 2 ml was given into glenohumeral joint space in adhesive capsulitis group and their pain and range of motion (ROM) were analyzed.

Results: 1) The incidence of adhesive capsulitis was higher in patients with higher injury level, older age and delayed start of rehabilitation therapy.

2) 10 cm visual analogue scale scores were significantly decreased after intra-articular steroid injection (p<0.01).

3) The shoulder ROM was increased after intra-articular steroid injection.

The shoulder ROM at pre-injection was 126o in flexion, 113o in abduction, 64o in external rotation and 51o in internal rotation. The shoulder ROM at 4 weeks after injection was 138o in flexion, 131o in abduction, 74o in external rotation and 77o in internal rotation.

Conclusion: There was a trend that the incidence of adhesive capsulitis was higher in patients with higher injury level, older age and delayed start of rehabilitation therapy. Further, it was suggested that intra-articular steroid injection was effective for reducing pain and improving ROM.

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The Effect of Intraarticular Injection of Hyaluronic Acid and Steroid in Adhesive Capsulitis of Shoulder.
Kim, Hye Wan , Kim, Hee Sang , Ahn, Kyung Hoi
J Korean Acad Rehabil Med 1999;23(1):117-123.

Objective: To evaluate the efficacy of intraarticular injection of hyaluronic acid and steroid in adhesive capsulitis of shoulder.

Method: Thirty-nine patients with adhesive capsulitis of shoulder were assigned at random to receive intraarticular injection into the glenohumeral joint. The treatment groups were divided into three: group A, triamcinolone 1 ml and 1% lidocaine 3 ml and normal saline 25 ml; group B, hyaluronic acid 2 ml and 1% lidocaine 3 ml and normal saline 25 ml; group C, hyaluronic acid 2 ml and 1% lidocaine 3 ml. The same physical therapy program was carried out for all patients. Pain was assessed by visual analogue scale (VAS) and range of motion (flexion, abduction, internal rotation and external rotation) was measured before injection, and at 30 minutes, 1 week and 2 weeks after injection.

Results: The shoulder range of motion (ROM) and VAS of three groups were all improved at 30 minutes, 1 week and 2 weeks after injection compared with those of preinjection, but there was no significant difference in ROM and VAS among three groups.

Conclusion: We concluded that intraarticular injection of hyaluronic acid would be a good treatment method in adhesive capsulitis of shoulder, specially in patients with risk of steroid use.

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The Effect of Cold Air Application for the Intraarticular and Skin Temperature Changes of Knees.
Baek, Seung Sug , Choi, Ki Sub , Park, Si Bog , Lee, Sang Gun , Kim, Young Ho , Yang, Gil Tae , Chang, Yun Hee
J Korean Acad Rehabil Med 1998;22(2):299-304.

The purposes of this study are to investigate the effect of the cold air application in the skin and intraarticular temperature changes and to observe the rebound temperature changes after cooling.

We recorded the changes of the skin surface and intraarticular temperatures of knees during and after the cold air application. The intraarticular temperature was measured by a temperature probe inserted into the knee joint cavity and the skin temperature by the infrared system. Eighteen healthy subjects were examined. The knee was cooled by a 5-minutes application of CRAis (Kyung-won Century, Korea) machine and the intraarticular and skin temperatures of knees were measured at every 0.5-minute during and after the cold therpy, then at every minute for 5 minutes, and every 5-minute for the next 110 minutes. We also evaluated the variables that might affect the skin and intraarticular temperature changes.

Results showed that the mean skin temperature dropped from 31.8℃ to 10.5℃ immediately after the cold air application for 5-minutes. The mean intraarticular temperature dropped from 33.9℃ to 30.0℃ after the cold air application for 5-minutes. Two hours after the initiation of treatment with cold air, the mean intraarticular temperatures did not recover to the baseline values(p<0.01). No significant correlations were found between the body mass index with the intraarticular and surface temperatures of knees. A highly significant correlation was noted between the baseline skin surface and intraarticular temperatures(p<0.01).

In conclusion, the reduction of the joint temperature by the cold air application using CRAis machine can be a useful treatment method for the synovitis of knees.

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