Objective To compare the accuracy of ultrasound-guided and non-guided botulinum toxin injections into the neck muscles involved in cervical dystonia.
Methods Two physicians examined six muscles (sternocleidomastoid, upper trapezius, levator scapulae, splenius capitis, scalenus anterior, and scalenus medius) from six fresh cadavers. Each physician injected ultrasound-guided and non-guided injections to each side of the cadaver’s neck muscles, respectively. Each physician then dissected the other physician’s injected muscle to identify the injection results. For each injection technique, different colored dyes were used. Dissection was performed to identify the results of the injections. The muscles were divided into two groups based on the difficulty of access: sternocleidomastoid and upper trapezius muscles (group A) and the levator scapulae, splenius capitis, scalenus anterior, and scalenus medius muscles (group B).
Results The ultrasound-guided and non-guided injection accuracies of the group B muscles were 95.8% and 54.2%, respectively (p<0.001), while the ultrasound-guided and non-guided injection accuracies of the group A muscles were 100% and 79.2%, respectively (p<0.05).
Conclusion Ultrasound-guided botulinum toxin injections into inaccessible neck muscles provide a higher degree of accuracy than non-guided injections. It may also be desirable to consider performing ultrasound-guided injections into accessible neck muscles.
Citations
Citations to this article as recorded by
Optimal target localization for botulinum toxin A in treating splenius muscles dystonia based on the distribution of intramuscular nerves and spindles Xiaojiao He, Sifeng Wen, Xuan Liu, Yutong Li, Shengbo Yang Anatomical Science International.2025;[Epub] CrossRef
Efficacy and Safety of Botulinum Toxin Type A Injection for Trapezius Muscle Contouring: A Systematic Review Krishan Mohan Kapoor, Anmol Batra, Amrit Kaur, Aanandita Kapoor, Tim Papadopoulos International Journal of Aesthetic Plastic Surgery.2025; 1(1): 76. CrossRef
Comparing Injection Methods of Botulinum Toxin A for Cervical Dystonia: A Systematic Review Hristo Shipkov, Petar Uchikov, Abdulrahman Imran, Zain Ul Hassan, Ivan Grozdev, Krasimir Kraev, Maria Kraeva, Nina Koleva, Maria Bozhkova, Stanislav Karamitev Life.2025; 15(6): 920. CrossRef
Botulinum Toxin for Isolated or Essential Head Tremor
New England Journal of Medicine.2024; 390(4): 383. CrossRef
Current use of neurotoxins for alleviating symptoms of cervical dystonia Stephen Aradi, Robert A. Hauser Expert Review of Neurotherapeutics.2024; 24(8): 787. CrossRef
Surface anatomy and levator scapulae muscle injection: A cadaveric investigation So-Youn Chang, Hee Young Lim, Sang-Hyun Kim, Jung-Woo Choi, Yong-Seok Nam, Jong In Lee Medicine.2024; 103(25): e38598. CrossRef
Enhancing Botulinum Toxin Injection Precision: The Efficacy of a Single Cadaveric Ultrasound Training Intervention for Improved Anatomical Localization Camille Heslot, Omar Khan, Alexis Schnitzler, Chloe Haldane, Romain David, Rajiv Reebye Toxins.2024; 16(7): 304. CrossRef
A Bayesian Network Meta-Analysis and Systematic Review of Guidance Techniques in Botulinum Toxin Injections and Their Hierarchy in the Treatment of Limb Spasticity Evridiki Asimakidou, Christos Sidiropoulos Toxins.2023; 15(4): 256. CrossRef
Improving the Efficacy of Botulinum Toxin for Cervical Dystonia: A Scoping Review Roberto Erro, Marina Picillo, Maria Teresa Pellecchia, Paolo Barone Toxins.2023; 15(6): 391. CrossRef
Muscle Ultrasound in Clinical Neurology: Diagnostic Uses and Guidance of Botulinum Toxin Injection Uwe Walter Journal of Neurosonology and Neuroimaging.2023; 15(1): 38. CrossRef
In-Plane Ultrasound-Guided Botulinum Toxin Injection to Lumbrical and Interosseus Upper Limb Muscles: Technical Report Alexandros Toliopoulos Cureus.2023;[Epub] CrossRef
Shoulder Spasticity Treatment With Botulinum Toxin: A Nationwide Cross-Sectional Survey of Clinical Practices Sérgio Pinho, Alexandre Camões-Barbosa, Madjer Hatia, Frederico Moeda, Xavier Melo, João Tocha Cureus.2023;[Epub] CrossRef
Does ultrasound-guidance improve the outcome of botulinum toxin injections in cervical dystonia? A. Kreisler, S. Djelad, C. Simonin, G. Baille, E. Mutez, A. Degardin, L. Defebvre, J. Labreuche, E. Cailliau, A. Duhamel Revue Neurologique.2022; 178(6): 591. CrossRef
Morphological characteristics of the posterior neck muscles and anatomical landmarks for botulinum toxin injections Bilge İpek Torun, Simel Kendir, Luis Filgueira, R. Shane Tubbs, Aysun Uz Surgical and Radiologic Anatomy.2021; 43(8): 1235. CrossRef
Ultrasound and Electromyography as Guidance Tools for the Botulinum Toxin Therapy in Cervical Dystonia G. Salazar, S. Ferreiro, M. Fragoso, J. Codas, H. Cruz Journal of Behavioral and Brain Science.2021; 11(02): 49. CrossRef
The Role of Ultrasound for the Personalized Botulinum Toxin Treatment of Cervical Dystonia Urban M. Fietzek, Devavrat Nene, Axel Schramm, Silke Appel-Cresswell, Zuzana Košutzká, Uwe Walter, Jörg Wissel, Steffen Berweck, Sylvain Chouinard, Tobias Bäumer Toxins.2021; 13(5): 365. CrossRef
Novel approaches to the treatment of cervical dystonia. The concept of dual navigation control A. P. Kovalenko, Z. A. Zalyalova, A. F. Ivolgin Neurology, Neuropsychiatry, Psychosomatics.2021; 13(6): 124. CrossRef
Spinal accessory nerve (SAN) injury mostly occurs during surgical procedures. SAN injury caused by manipulation therapy has been rarely reported. We present a rare case of SAN injury associated with manipulation therapy showing scapular winging and droopy shoulder. A 42-year-old woman visited our outpatient clinic complaining of pain and limited active range of motion (ROM) in right shoulder and scapular winging after manipulation therapy. Needle electromyography and nerve conduction study suggested SAN injury. Physical therapy (PT) three times a week for 2 weeks were prescribed. After a total of 6 sessions of PT and modality, the patient reported that the pain was gradually relieved during shoulder flexion and abduction with improved active ROM of shoulder. Over the course of 2 months follow-up, the patient reported almost recovered shoulder ROM and strength as before. She did not complain of shoulder pain any more.
Citations
Citations to this article as recorded by
Age Group-Specific Improvement of Vertebral Scoliosis after the Surgical Release of Congenital Muscular Torticollis Jong Min Choi, Seong Hoon Seol, Jae Hyun Kim, Chan Min Chung, Myong Chul Park Archives of Plastic Surgery.2024; 51(01): 072. CrossRef
Spinal Accessory Nerve Injury following Spinal Adjustment: Case Report and Literature Review of the Outcome of Accessory Nerve Pathology as Result of Blunt Trauma (Spinal Accessory Nerve Palsy after Spinal Adjustment) Sulaiman Alanazi, Areej M. Alawfi, Bander S. Alrashedan, Reem A. Almohaini, Majed M. Shogair, Talal A. Alshehri, Eyal Itshayek Case Reports in Orthopedics.2024;[Epub] CrossRef
Cervical Myelopathy after Neck Manipulation Jin Sun Kang, Sung Hoon Lee, Ki Hong Won, Tae Ki Choi, Su Min Lee, Eun Young Kang, Hyun Kyung Lee, Youn Kyung Cho Clinical Pain.2023; 22(2): 122. CrossRef
Iatrogenic injury of the spinal accessory nerve in selective superficial parotidectomy Ida M. Stefanizzi, Giulia Petroni, Margherita Pallocci, Michele Treglia, Mauro Arcangeli, Pasquale Giugliano, Alessandro Feola Chirurgia.2020;[Epub] CrossRef
Ultrasonographic diagnosis of an iatrogenic winged scapula caused by spinal accessory neuropathy combined with dorsal scapular neuropathy - a case report Alper Uysal, Nimet Bilge Kalkan European Journal of Medical Case Reports.2020;[Epub] CrossRef