Objective To investigate the clinical demographics and rehabilitative assessments of encephalitis survivors admitted to a rehabilitation center, and to confirm the effects of inpatient rehabilitation manifested by changes in muscle strength and function after hospitalization.
Methods Data of encephalitis survivors who received rehabilitation at our institution from August 2009 to August 2019 were reviewed. Medical charts were retrospectively reviewed, and motor, functional, and cognitive assessments were collected. Manual muscle testing (MMT), Fugl-Meyer Assessment (FMA), Berg Balance Scale (BBS), Functional Ambulation Category (FAC), Korean version of Modified Barthel Index (K-MBI), grip strength, Box and Block Test (BBT), and Korean version of Mini-Mental State Examination (K-MMSE) were performed, and the results upon admission and discharge were compared and analyzed.
Results Most of the patients with encephalitis admitted to our institution had viral or autoimmune etiologies. The assessment results of 18 encephalitis patients upon admission and discharge were compared. The total K-MBI score, FAC, grip strength, and BBT significantly improved, but not the MMT and FMA. Subgroup analysis was performed for viral and autoimmune encephalitis, which are the main causes of the disease, but there was no difference in items with significant changes before and after hospitalization.
Conclusion Encephalitis survivors showed a significant improvement in functional assessment scale during their hospital stay through rehabilitation, without significant changes in motor strength. Hence, we can conclude that encephalitis survivors benefit from inpatient rehabilitation, targeting functional gains in activities of daily living training more than motor strength.
Citations
Citations to this article as recorded by
Activated Microglia Mediate the Motor Neuron‐, Synaptic Denervation‐ and Muscle Wasting‐Changes in Burn Injured Mice Jingyuan Chen, Yoshinori Kitagawa, Fei Xie, Haobo Li, William R. Kem, Zerong You, Shingo Yasuhara, J. A. Jeevendra Martyn Journal of Cachexia, Sarcopenia and Muscle.2025;[Epub] CrossRef
Handgrip strength and upper limb functional performance measures in people over 18 years old: Analysis of relationships and influencing factors Julio Ernesto Pérez-Parra, Claudia Patricia Henao-Lema, Anyi Vanesa Arcos-Rodríguez, Natalia López-Ocampo, Carolina Castaño-García, Olga Patricia Pérez-Gamboa Journal of Hand Therapy.2024; 37(1): 101. CrossRef
Outcome and Sequelae of Autoimmune Encephalitis Kathryn A. Kvam, Jean-Paul Stahl, Felicia C. Chow, Ariane Soldatos, Pierre Tattevin, James Sejvar, Alexandra Mailles Journal of Clinical Neurology.2024; 20(1): 3. CrossRef
Effect of Timing of Rehabilitation Nursing Intervention on Children with Acute Viral Encephalitis Haiyan Zhang, Shuangying Huang, Biyun He, Lingming Shen, Xiaoqing Li, Chen Shen, Bo Chen Iranian Journal of Pediatrics.2024;[Epub] CrossRef
State of the Art: Acute Encephalitis Karen C Bloch, Carol Glaser, David Gaston, Arun Venkatesan Clinical Infectious Diseases.2023; 77(5): e14. CrossRef
Objective To identify the prevalence and characteristics of neuropathic pain (NP) in patients with spinal cord injury (SCI) and to investigate associations between NP and demographic or disease-related variables.
Methods We retrospectively reviewed medical records of patients with SCI whose pain was classified according to the International Spinal Cord Injury Pain classifications at a single hospital. Multiple statistical analyses were employed. Patients aged <19 years, and patients with other neurological disorders and congenital conditions were excluded.
Results Of 366 patients, 253 patients (69.1%) with SCI had NP. Patients who were married or had traumatic injury or depressive mood had a higher prevalence rate. When other variables were controlled, marital status and depressive mood were found to be predictors of NP. There was no association between the prevalence of NP and other demographic or clinical variables. The mean Numeric Rating Scale (NRS) of NP was 4.52, and patients mainly described pain as tingling, squeezing, and painful cold. Females and those with below-level NP reported more intense pain. An NRS cut-off value of 4.5 was determined as the most appropriate value to discriminate between patients taking pain medication and those who did not.
Conclusion In total, 69.1% of patients with SCI complained of NP, indicating that NP was a major complication. Treatment planning for patients with SCI and NP should consider that marital status, mood, sex, and pain subtype may affect NP, which should be actively managed in patients with an NRS ≥4.5.
Citations
Citations to this article as recorded by
Mechanisms and Therapeutic Prospects of Microglia-Astrocyte Interactions in Neuropathic Pain Following Spinal Cord Injury Yinuo Liu, Xintong Cai, Bowen Shi, Yajie Mo, Jianmin Zhang, Wenting Luo, Bodong Yu, Xi Li Molecular Neurobiology.2025; 62(4): 4654. CrossRef
Comparative outcomes of microsurgical dorsal root entry zone lesioning (DREZotomy) for intractable neuropathic pain in spinal cord and cauda equina injuries Bunpot Sitthinamsuwan, Tanawat Ounahachok, Sawanee Pumseenil, Sarun Nunta-aree Neurosurgical Review.2025;[Epub] CrossRef
Efficacy of neuromodulation and rehabilitation approaches on pain relief in patients with spinal cord injury: a systematic review and meta-analysis Simona Portaro, Angelo Alito, Giulia Leonardi, Nicola Marotta, Adriana Tisano, Daniele Bruschetta, Umile Giuseppe Longo, Antonio Ammendolia, Demetrio Milardi, Alessandro de Sire Neurological Sciences.2025;[Epub] CrossRef
Correlation of Severity of Neuropathic Pain in Traumatic Spinal Cord Injury Patients with Sociodemographic and Clinical Characteristics Including Depression and Quality of Life: A Cross-sectional Study Arun Yadav, Mrinal Joshi, Shivangi Yadav Indian Journal of Physical Medicine and Rehabilitation.2025; 35(2): 128. CrossRef
Curcumin reduces pain after spinal cord injury in rats by decreasing oxidative stress and increasing GABAA receptor and GAD65 levels Maryam Hadadi, Mohammad Mojtaba Farazi, Mehrnaz Mehrabani, Mahsa Tashakori-Miyanroudi, Zahra Behroozi Scientific Reports.2025;[Epub] CrossRef
Clinical Characteristics of Adults Living with a Spinal Cord Injury Across the Continuum of Care: A Population-Based Cross-Sectional Study Matteo Ponzano, Anja Declercq, Melissa Ziraldo, John P. Hirdes Journal of Clinical Medicine.2025; 14(9): 3060. CrossRef
Occurrence of neuropathic pain and its characteristics in patients with traumatic spinal cord injury Arun Yadav, Mrinal Joshi The Journal of Spinal Cord Medicine.2024; 47(6): 952. CrossRef
Post-discharge follow-up of patients with spine trauma in the National Spinal Cord Injury Registry of Iran during the COVID-19 pandemic: Challenges and lessons learned Zahra Azadmanjir, Moein Khormali, Mohsen Sadeghi-Naini, Vali Baigi, Habibollah Pirnejad, Mohammad Dashtkoohi, Zahra Ghodsi, Seyed Behnam Jazayeri, Aidin Shakeri, Mahdi Mohammadzadeh, Laleh Bagheri, Mohammad-Sajjad Lotfi, Salman Daliri, Amir Azarhomayoun, Chinese Journal of Traumatology.2024; 27(3): 173. CrossRef
Randomised, double-blind, placebo-controlled, parallel-group, multicentric, phase IIA clinical trial for evaluating the safety, tolerability, and therapeutic efficacy of daily oral administration of NFX88 to treat neuropathic pain in individuals with spin Pablo V. Escribá, Ángel M. Gil-Agudo, Joan Vidal Samsó, Judith Sánchez-Raya, Sebastián Salvador-de la Barrera, Vanesa Soto-León, Natacha León-Álvarez, Bosco Méndez Ferrer, Miguel David Membrilla-Mesa, Carolina Redondo Galán, Jesús Benito-Penalva, Antonio Spinal Cord.2024; 62(8): 454. CrossRef
Low back pain classifications and their associations with disability, quality-of-life, and sociodemographic factors: a comprehensive examination using the PainDETECT questionnaire Zachary Gan, Stone Sima, Samuel Lapkin, Ashish D. Diwan Current Medical Research and Opinion.2024; 40(8): 1379. CrossRef
Research progress in neuropathic pain after spinal cord injury: a bibliometric study from 2013 to 2024 Qin Huiqing, Lin Weishan, Gui Yuchang, Tang Yun, Xu Jianwen Frontiers in Neurology.2024;[Epub] CrossRef
Prevalence and Determinants of Pain in Spinal Cord Injury During Initial Inpatient Rehabilitation: Data From the Dutch Spinal Cord Injury Database Tim C. Crul, Marcel W.M. Post, Johanna M.A. Visser-Meily, Janneke M. Stolwijk-Swüste Archives of Physical Medicine and Rehabilitation.2023; 104(1): 74. CrossRef
Ectopic expression of Nav1.7 in spinal dorsal horn neurons induced by NGF contributes to neuropathic pain in a mouse spinal cord injury model Yan Fu, Liting Sun, Fengting Zhu, Wei Xia, Ting Wen, Ruilong Xia, Xin Yu, Dan Xu, Changgeng Peng Frontiers in Molecular Neuroscience.2023;[Epub] CrossRef
Precision neuromodulation: Promises and challenges of spinal stimulation for multi-modal rehabilitation Maria F. Bandres, Jefferson L. Gomes, Gerson N. Moreno Romero, Avery R. Twyman, Jacob Graves McPherson Frontiers in Rehabilitation Sciences.2023;[Epub] CrossRef
A Silver Lining of Neuropathic Pain: Predicting Favorable Functional Outcome in Spinal Cord Injury Mu-Lan Xu, Xiang-Bo Wu, Ying Liang, Ning Li, Xu Hu, Xiao-Dong Lin, Miao-Qiao Sun, Chun-Qiu Dai, Dan Niu, Yan-Rong Zhang, Hui Cao, Chen-Guang Zhao, Xiao-Long Sun, Hua Yuan Journal of Pain Research.2023; Volume 16: 2619. CrossRef
Feasibility of using remotely delivered Spring Forest Qigong to reduce neuropathic pain in adults with spinal cord injury: a pilot study Ann Van de Winckel, Sydney T. Carpentier, Wei Deng, Lin Zhang, Angela Philippus, Ricardo Battaglino, Leslie R. Morse Frontiers in Physiology.2023;[Epub] CrossRef
An Exploratory EEG Analysis on the Effects of Virtual Reality in People with Neuropathic Pain Following Spinal Cord Injury Yvonne Tran, Philip Austin, Charles Lo, Ashley Craig, James W. Middleton, Paul J. Wrigley, Philip Siddall Sensors.2022; 22(7): 2629. CrossRef
Systematic analysis of critical genes and pathways identified a signature of neuropathic pain after spinal cord injury Zefu Li, Huiying Bai, Ruoyu Zhang, Bohan Chen, Junmin Wang, Bohan Xue, Xiuhua Ren, Jiarui Wang, Yanjie Jia, Weidong Zang, Jian Wang, Xuemei Chen European Journal of Neuroscience.2022; 56(2): 3991. CrossRef
Phenotypes of Motor Deficit and Pain after Experimental Spinal Cord Injury Volodymyr Krotov, Volodymyr Medvediev, Ibrahim Abdallah, Arseniy Bozhenko, Mykhailo Tatarchuk, Yevheniia Ishchenko, Leonid Pichkur, Serhii Savosko, Vitaliy Tsymbaliuk, Olga Kopach, Nana Voitenko Bioengineering.2022; 9(6): 262. CrossRef
Peripheral Immune Dysfunction: A Problem of Central Importance after Spinal Cord Injury Marisa Jeffries, Veronica Tom Biology.2021; 10(9): 928. CrossRef