Annals of Rehabilitation Medicine

"Mi Jin Hong"

Original Articles

Cancer rehabilitation

Effects of Home-Based Rehabilitation for Patients With Advanced Lung Cancer Undergoing Platinum-Based Chemotherapy: A Randomized Controlled Trial: Mi Jin Hong, Yung Jin Lee, Jong Bum Park, Sin Yung Woo, Seungcheol Lee, Hokwan Ko, Ji Woong Son; Ann Rehabil Med 2025;49(3):164-174. Published online June 20, 2025; DOI: https://doi.org/10.5535/arm.240072

Abstract
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Objective
To investigate the effects of a home-based rehabilitation program on physical capacity, lung function, and health-related quality of life (QOL) in patients with advanced lung cancer undergoing platinum-based chemotherapy.
Methods
Between December 2021 and December 2023, participants were randomly assigned to exercise and control groups. The exercise group engaged in a home-based exercise program, including respiratory, aerobic, and resistance training, for 60 minutes per session, three times per week, before the first tumor response evaluation. Outcome evaluations included the 6-minute walk test, spirometry to measure lung function (specifically assessing forced expiratory volume in 1 second [FEV1] and forced vital capacity, hand grip strength, and QOL assessments using the Short Form 36-Item Health Survey and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Lung Cancer Module 29. Participants were assessed at baseline, post-intervention, and followed up for 1 year.
Results
Twenty-one of the 26 participants completed the study. The control group showed a significant decrease in FEV1 (p=0.011). Delays in chemotherapy occurred in 40.0% of participants in the control group but none in the exercise group (p=0.019). Mental health showed improvement in the exercise group (p=0.041), whereas adverse effects were more common in the control group (p=0.007), according to QOL questionnaire results.
Conclusion
Home-based rehabilitation during chemotherapy may help maintain lung function, improve mental health, and reduce side effects in patients with lung cancer, warranting further research.

Citations

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Nurse-supported hybrid home-based pulmonary rehabilitation improves psychological distress, quality of life, and functional performance in advanced lung cancer: A randomized controlled trial
Wei-Ling Liu, Jung-Yien Chien, Yu-Ying Lu, Kuei-Fen Liu
European Journal of Oncology Nursing.2026; 81: 103130. CrossRef
The Role of Pulmonary Rehabilitation in Inoperable Advanced Lung Cancer: A Scoping Review
Huang Yi, Zeng Fan, Feng Lijuan, Ricardo Santiago Gomez
European Journal of Cancer Care.2026;[Epub] CrossRef
Exercise during chemotherapy or chemoradiotherapy and treatment delivery and tumor response outcomes: a scoping review
Takuya Fukushima, Jiro Nakano, Katsuyoshi Suzuki, Keiichi Osaki, Takashi Tanaka, Taro Okayama, Junichiro Inoue, Jack B. Fu, Shinichiro Morishita
BMC Cancer.2026;[Epub] CrossRef
Exercise Experiences and Behavioral Adaptation During the Inter-Chemotherapy Interval Among Patients With Lung Cancer Receiving Platinum-Based Chemotherapy: A Qualitative Study
Lingling Pan, Jiayue Wu, Qianyun Jiang, Linyan Wang, Yumei Li
Cancer Nursing.2026;[Epub] CrossRef
Construction of the central symptom cluster management program for patients with lung cancer undergoing chemotherapy: a Delphi study
Le Zhang, Yuanyuan Luo, Dongmei Mao, Benxiang Zhu, Zhihui Yang, Cui Cui, Jingxia Miao, Lili Zhang
BMC Nursing.2025;[Epub] CrossRef

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Quantitative Evaluation of Post-stroke Spasticity Using Neurophysiological and Radiological Tools: A Pilot Study: Mi Jin Hong, Jong Bum Park, Yung Jin Lee, Hyeong Tae Kim, Won Chul Lee, Cheol Mog Hwang, Hyun Kyoon Lim, Dong Hyun Lee; Ann Rehabil Med 2018;42(3):384-395. Published online June 27, 2018; DOI: https://doi.org/10.5535/arm.2018.42.3.384

Abstract
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Objective
To determine the possibility of a new measurement tool using electromyography and ultrasonography for quantitative spasticity assessment in post-stroke patients.
Methods
Eight hemiplegic stroke patients with ankle plantarflexor spasticity confirmed by a Modified Ashworth Scale (MAS) were enrolled. Spasticity was evaluated using the MAS and Modified Tardieu Scale (MTS). Each subject underwent surface electromyography (sEMG) using the Brain Motor Control Assessment (BMCA) protocol and was compared with a healthy control group. Using ultrasonography, muscle architecture and elasticity index were measured from the medial gastrocnemius muscle (GCM) on the affected and unaffected sides.
Results
MAS and MTS revealed significant correlation with sEMG activity. The fascicle length and pennation angle were significantly decreased in the medial GCM on the hemiplegic side compared with the unaffected side. The elasticity index of the spastic medial GCM was significantly increased compared with the unaffected side. The MTS X and R2–R1 values were significantly correlated with the elasticity index in the hemiplegic GCM. The relationship between clinical evaluation tools and both BMCA and sonoelastography was linear, but not statistically significant in the multiple regression analysis.
Conclusion
The BMCA protocol and ultrasonographic evaluation provide objective assessment of post-stroke spasticity. Further studies are necessary to conduct accurate assessment and treatment of spasticity.

Citations

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Immediate effect of acupuncture on abnormal antagonist activity in a chronic post-stroke patient: a case report
Ruka Nobe
Acupuncture in Medicine.2026;[Epub] CrossRef
Electromyographic features for quantitative assessment of lower limb spasticity after stroke: a feasibility study
Lin Wu, Benjian Zou, Jiawei Liu, Chao Wang, Samit Chakrabarty, Ping Zhou, Tianzhe Bao, Sheng Quan Xie
Medical & Biological Engineering & Computing.2026; 64(4): 1517. CrossRef
Non-Invasive Assessment of Hypertonic Muscle Properties After Botulinum Toxin Neuromodulation in Post-Stroke Patients: A Systematic Literature Review of Recent Evidence (2023–2025) on Mobility and Balance
Sebastian Giuvara, Gelu Onose, Constantin Munteanu, Cristina Popescu, Aura Spinu, Andrada Mirea, Aurelian Anghelescu
Life.2026; 16(7): 1120. CrossRef
Feasibility of shear wave elastography to assess upper limb spasticity in patients after brain injury
Ganglin Chen, Ling Ren, Zhenguo Wu, Xianrui Hu, Jing He
Disability and Rehabilitation.2025; 47(19): 5133. CrossRef
Shear wave elastography in the assessment of gastrocnemius spastic muscle elasticity: influences of ankle position and muscle contraction
Marine DEVIS, Frédéric LECOUVET, Thierry LEJEUNE, Gaëtan STOQUART
European Journal of Physical and Rehabilitation Medicine.2025;[Epub] CrossRef
Exploring the Time to Onset and Early Predictors of Poststroke Spasticity Combined With Surface Electromyography: Protocol for a Nested Case-Control Study
Simeng Song, Shiliang Wang, Shanshan Zeng, Wenqing Wu, Lingying Wu, Xukun Tang, Xiongxing Sun, Dahua Wu, Le Xie
JMIR Research Protocols.2025; 14: e65829. CrossRef
The effect of mechanical digit sensory stimulation on upper limb motor function recovery in convalescent stroke patients with hemiplegia
Kexin Yao, Qiqi Li, Yuqin Ma, Yaxing Tian, Shuting Zhang, Yongfeng Hong
Clinical Neurology and Neurosurgery.2025; 257: 109027. CrossRef
Dose–response effectiveness of focused shockwave therapy on ultrasonographic muscular properties in patients with stroke exhibiting ankle spasticity
Shu-Mei Yang, Hung-Hsi Lin, Yen-Hua Chen, You-Lin Lu, Chueh-Hung Wu, Wen-Shiang Chen, Meng-Ting Lin
Journal of NeuroEngineering and Rehabilitation.2025;[Epub] CrossRef
Automated assessment of upper limb spasticity in stroke patients with fusion of multichannel surface electromyography features
Xin Li, Feiyu Nong, Xu Zhang, Lin Chen, Tian Li, Shengliang Shi, Yaobin Long
Journal of Rehabilitation Medicine.2025; 57: jrm43745. CrossRef
Correlation of Gastrocnemius Muscle Quality With Balance, Appendicular Skeletal Mass, and Fall Risk in Osteoporotic Women: A Musculoskeletal Sonography Assessment During Rest and Activity
Elham Bagheri Yekta, Giti Torkaman, Leila Aghaghazvini
Journal of Clinical Densitometry.2025; 28(4): 101633. CrossRef
Efeito agudo do ultrassom no padrão espástico do bíceps braquial em indivíduos com distúrbios neurológicos
João Sávio Carneiro Silva, Letícia Costa Mengoni, Gabriel Pádua da Silva, Wellington Marcelo Queixas Moreira, Oswaldo Luiz Stamato Taube, Bruno Ferreira
RCMOS - Revista Científica Multidisciplinar O Saber.2025;[Epub] CrossRef
Automated EMG-Based Classification of Upper Extremity Motor Impairment Levels in Subacute Stroke
Alexey Anastasiev, Hideki Kadone, Aiki Marushima, Hiroki Watanabe, Alexander Zaboronok, Shinya Watanabe, Akira Matsumura, Kenji Suzuki, Yuji Matsumaru, Hiroyuki Nishiyama, Eiichi Ishikawa
Sensors.2025; 25(22): 6829. CrossRef
Conformal, stretchable, breathable, wireless epidermal surface electromyography sensor system for hand gesture recognition and rehabilitation of stroke hand function
Kerong Yang, Senhao Zhang, Ying Yang, Xiaoman Liu, Jiuqiang Li, Benkun Bao, Chang Liu, Hongbo Yang, Kai Guo, Huanyu Cheng
Materials & Design.2024; 243: 113029. CrossRef
Assessing muscle architecture with ultrasound: implications for spasticity
Ève Boissonnault, April Hyon, Michael C. Munin, Mirko Filippetti, Alessandro Picelli, Chloe Haldane, Rajiv Reebye
European Journal of Translational Myology.2024;[Epub] CrossRef
Comparative study on muscle-tendon stiffness and balance impairment in postmenopausal women: a focus on osteosarcopenia and osteoporosis
Elham Bagheri Yekta, Giti Torkaman, Leila Aghaghazvini
Aging Clinical and Experimental Research.2024;[Epub] CrossRef
Examination of evaluation indicators for spasticity in stroke patients using ultrasound imaging equipment
Takahiro Okazaki, Shota Nagai
Journal of Physical Therapy Science.2024; 36(12): 776. CrossRef
Utility of Ultrasound Elastography to Evaluate Poststroke Spasticity and Therapeutic Efficacy: A Narrative Review
Meng-Ting Lin, Shu-Mei Yang, Hao-Wei Wu, Yen-Hua Chen, Chueh-Hung Wu
Journal of Medical Ultrasound.2023; 31(3): 171. CrossRef
Ultrasound elastography in the assessment of post-stroke muscle stiffness: a systematic review
Jacqueline Roots, Gabriel S Trajano, Davide Fontanarosa
Insights into Imaging.2022;[Epub] CrossRef
Technology-assisted assessment of spasticity: a systematic review
Xinliang Guo, Rebecca Wallace, Ying Tan, Denny Oetomo, Marlena Klaic, Vincent Crocher
Journal of NeuroEngineering and Rehabilitation.2022;[Epub] CrossRef
Ultrasound Elastography in the Assessment of the Stiffness of Spastic Muscles: A Systematic Review
Laura Daniela Ordierez Zúñiga, Carlos Alberto Gaviria López, Elizabeth Roldán González
Ultrasound in Medicine & Biology.2021; 47(6): 1448. CrossRef
Using Surface Electromyography to Evaluate the Efficacy of Governor Vessel Electroacupuncture in Poststroke Lower Limb Spasticity: Study Protocol for a Randomized Controlled Parallel Trial
Jingwen Li, Kaiqi Su, Jinjin Mei, Yiying Wang, Shuai Yin, Yanchao Hu, Wenxue Hao, Xiaodong Feng, Ruiqing Li, Hongcai Shang
Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1. CrossRef
Muscle and tendon properties of the spastic lower leg after stroke defined by ultrasonography: a systematic review
Fabienne SCHILLEBEECKX, An DE GROEF, Nathalie DE BEUKELAER, Kaat DESLOOVERE, Geert VERHEYDEN, Koen PEERS
European Journal of Physical and Rehabilitation Medicine.2021;[Epub] CrossRef
Soft Rehabilitation Actuator With Integrated Post-stroke Finger Spasticity Evaluation
Ho Lam Heung, Zhi Qiang Tang, Xiang Qian Shi, Kai Yu Tong, Zheng Li
Frontiers in Bioengineering and Biotechnology.2020;[Epub] CrossRef
A domestic robotic rehabilitation device for assessment of wrist function for outpatients
Matthias Panny, Andreas Mayr, Marco Nagiller, Yeongmi Kim
Journal of Rehabilitation and Assistive Technologies Engineering.2020;[Epub] CrossRef

15,176 View
365 Download
24 Web of Science
24 Crossref

Case Reports

Identifying the KAT6B Mutation via Diagnostic Exome Sequencing to Diagnose Say-Barber-Biesecker-Young-Simpson Syndrome in Three Generations of a Family: Yong Rok Kim, Jong Bum Park, Yung Jin Lee, Mi Jin Hong, Hyeong Tae Kim, Hyon J. Kim; Ann Rehabil Med 2017;41(3):505-510. Published online June 29, 2017; DOI: https://doi.org/10.5535/arm.2017.41.3.505

Abstract
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Diagnostic exome sequencing (DES) is a powerful tool to analyze the pathogenic variants leading to development delay (DD) and intellectual disability (ID). Recently, heterozygous de novo mutation of the histone acetyltransferase encoding gene KAT6B has been recognized as causing a syndrome with congenital anomalies and intellectual disability, namely Say-Barber-Biesecker-Young-Simpson (SBBYS) syndrome. Here we report a case of SBBYS syndrome in a third generation Korean family affected with a missense mutation in KAT6B, c.2292C>T p.(His767Tyr) identified by DES. This is the first confirmed familial inherited mutation of the KAT6B reported worldwide. Our case emphasizes again the importance of basic physical examination and taking a family history. Furthermore, advances in genetic diagnostic tools are becoming key to identifying the etiology of DD and ID. This allows a physiatrist to predict the disease's clinical evolution with relative certainty, and offer an appropriate rehabilitation plan for patients.

Citations

Citations to this article as recorded by

Phenotypic Characterization of Seven Pediatric Patients Diagnosed With KAT6B‐Related Disorders: Case Series and Review of the Literature
Vittorio Maglione, Antonio Pizzuti, Gioia Mastromoro, Eleonora Cresta, Paola Favata, Maria Cristina Digilio, Rossella Capolino, Maria Lisa Dentici, Lorenzo Sinibaldi, Antonio Novelli, Marco Tartaglia, Gianluca Terrin, Viviana Cardilli
American Journal of Medical Genetics Part A.2025;[Epub] CrossRef
Variable expressivity of a transmitted pathogenic KAT6B variant
Ninna Bager Rasmussen, Pernille Axél Gregersen, Trine Østergaard Nielsen, Line Graven Lyngdorf, Christine Kroer Nielsen, Casper Kruse, Michael Bayat, Philippe M. Campeau, Anne Skakkebæk
European Journal of Medical Genetics.2025; 76: 105020. CrossRef
De novo KAT6B mutation causes Say–Barber–Biesecker–Young–Simpson variant of Ohdo syndrome in an Iranian boy: a case report
Behzad Davarnia, Mohammad Panahi, Bahareh Rahimi, Hassan Anari, Reza Farajollahi, Ehsan Abbaspour Rodbaneh, Farhad Jeddi
Journal of Medical Case Reports.2024;[Epub] CrossRef
Clinical heterogeneity of polish patients with KAT6B–related disorder
Klaniewska Magdalena, Bolanowska‐Tyszko Anna, Latos‐Bielenska Anna, Jezela‐Stanek Aleksandra, Szczaluba Krzysztof, Krajewska‐Walasek Malgorzata, Ciara Elzbieta, Pelc Magdalena, Jurkiewicz Dorota, Stawinski Piotr, Zubkiewicz‐Kucharska Agnieszka, Rydzanicz
Molecular Genetics & Genomic Medicine.2023;[Epub] CrossRef
Delineation of a Phenotype Caused by a KAT6B Missense Variant Not Resembling Say-Barber-Biesecker-Young-Simpson and Genitopatellar Syndromes
Naoto Nishimura, Yumi Enomoto, Tatsuro Kumaki, Hiroaki Murakami, Azusa Ikeda, Tomohide Goto, Kenji Kurosawa
Molecular Syndromology.2022; 13(3): 221. CrossRef
A neonate with Say–Barber–Biesecker–Young–Simpson syndrome with a novel pathogenic mutation in KAT6B gene: A case report
Ji Hye Shin, Han Hyuk Lim, Mi Hyeon Gang, Seon Young Kim, Shin-seung Yang, Mea-young Chang
Journal of Genetic Medicine.2021; 18(2): 147. CrossRef
Mutación de novo en KAT6B, síndrome Say-Barber-Biesecker-Young-Simpson y trastorno específico del lenguaje
D.M. Fernández-Mayoralas, B. Calleja-Pérez, S. Álvarez, A. Fernández-Jaén
Neurología.2020; 35(8): 601. CrossRef
A novel pathogenic frameshift variant of KAT6B identified by clinical exome sequencing in a newborn with the Say–Barber–Biesecker–Young–Simpson syndrome
Rodrigo Mendez, Marisol Delea, Liliana Dain, Monica Rittler
Clinical Dysmorphology.2020; 29(1): 42. CrossRef
Further delineation of the clinical spectrum of KAT6B disorders and allelic series of pathogenic variants
Li Xin Zhang, Gabrielle Lemire, Claudia Gonzaga-Jauregui, Sirinart Molidperee, Carolina Galaz-Montoya, David S. Liu, Alain Verloes, Amelle G. Shillington, Kosuke Izumi, Alyssa L. Ritter, Beth Keena, Elaine Zackai, Dong Li, Elizabeth Bhoj, Jennifer M. Tarp
Genetics in Medicine.2020; 22(8): 1338. CrossRef
De novo KAT6B mutation, Say-Barber-Biesecker-Young-Simpson syndrome, and specific language impairment
D.M. Fernández-Mayoralas, B. Calleja-Pérez, S. Álvarez, A. Fernández-Jaén
Neurología (English Edition).2020; 35(8): 601. CrossRef
The key roles of the lysine acetyltransferases KAT6A and KAT6B in physiology and pathology
Naama Wiesel-Motiuk, Yehuda G. Assaraf
Drug Resistance Updates.2020; 53: 100729. CrossRef
Novel KAT6B proximal familial variant expands genotypic and phenotypic spectrum
T. Michael Yates, Claire L.M. Langley, Detelina Grozeva, F. Lucy Raymond, Diana S. Johnson
Clinical Genetics.2019; 95(2): 334. CrossRef
The many lives of KATs — detectors, integrators and modulators of the cellular environment
Bilal N. Sheikh, Asifa Akhtar
Nature Reviews Genetics.2019; 20(1): 7. CrossRef

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Posterior Deltoid-to-Triceps Tendon Transfer for Elbow Extension in a Tetraplegia Patient: A Case Report: Ji Hun Jeong, Jong Bum Park, Dong Heun Ahn, Yong Rok Kim, Mi Jin Hong, Yung Jin Lee, Chang-il Park, Youn Moo Heo; Ann Rehabil Med 2016;40(2):351-355. Published online April 25, 2016; DOI: https://doi.org/10.5535/arm.2016.40.2.351

Abstract
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In tetraplegia patients, activities of daily living are highly dependent on the remaining upper limb functions. In other countries, upper limb reconstruction surgery to improve function has been applied to diverse cases, but few cases have been reported in Korea. The current authors experienced a case of posterior deltoid-to-triceps tendon transfer and rehabilitation in a complete spinal cord injury with a C6 neurologic level, and we introduce the case—a 36-year-old man—with a literature review. The patient's muscle strength in C5 C6 muscles were normal, but C7 muscles were trace, and the Spinal Cord Independence Measure III (SCIM III) score was 24. The tendon of the posterior deltoid was transferred to the triceps brachii muscle, and then the patient received comprehensive rehabilitative treatment. His C7 muscle strength in the right upper extremity was enhanced from trace to fair, and his SCIM III score improved to 29.

Citations

Citations to this article as recorded by

Transfer of Middle and Posterior Deltoid Extended by the Lateral Intermuscular Septum for Elbow Extension Reconstruction
Jayme A. Bertelli, Leonardo D. Lanzarin, Dashiel Cañizares, Fernando Levaro, Mohammed Tahir, Francisco Soldado
The Journal of Hand Surgery.2026; 51(2): 183. CrossRef