Kyungmin Kim, Sung Hoon Kim, Ji Hyun Kim, Sang Yeol Yong, Won Woo Choi, Sun Jung Kim, Hyuk Do Kim, Kyung Joon Oh, Dae Ryong Kang, Sehwa Hong, Jiseon Hong
Ann Rehabil Med 2024;48(1):50-56. Published online December 12, 2023
Objective To assess the safety and effectiveness of high-density light-emitting diode (LED) irradiation therapy in patients with hand osteoarthritis (OA) and compare the pre- and post-intervention symptoms.
Methods Twenty-three patients with hand OA underwent eight sessions of high-density LED irradiation therapy directed at the five most painful areas in the finger joints. Each session lasted for 18 minutes; and the sessions were conducted twice a week, for 4 weeks. We evaluated the degree of pain using the visual analogue scale, ring size, and passive range of motion (flexion+extension) for two most painful joints from the baseline to post-therapy (weeks 4 and 6).
Results High-density LED irradiation therapy significantly reduced the pain posttreatment compared with that observed at the baseline (p<0.001). Although improvements were observed in ring size and joint range of motion at 4 and 6 weeks, they were not statistically significant (p>0.05). No adverse events were observed.
Conclusion We examined the safety and effectiveness of high-density LED irradiation therapy in reducing pain and hand swelling and improving joint mobility in patients with hand OA. These results suggest that high-density LED irradiation therapy has the potential to be an important strategy for managing hand OA.
Citations
Citations to this article as recorded by
Letter to the Editor: Efficacy and Safety of High Density LED Irradiation Therapy for Patients With Hand Osteoarthritis: A Single-Center Clinical Study Vanshika Agarwal, Jeyanthi. S, Adarsh Sharma Annals of Rehabilitation Medicine.2025; 49(1): 1. CrossRef
Response: Efficacy and Safety of High Density LED Irradiation Therapy for Patients With Hand Osteoarthritis: A Single-Center Clinical Study (Ann Rehabil Med 2024;48:50-6) Jiseon Hong Annals of Rehabilitation Medicine.2025; 49(1): 3. CrossRef
Photobiomodulation Literature Watch December 2023 James D. Carroll Photobiomodulation, Photomedicine, and Laser Surgery.2024; 42(10): 660. CrossRef
Objective To assess the role of miRNA-21 and miRNA-223 in a balloon-compression model of spinal cord injury (SCI).
Methods A total of 50 male Wistar rats (n=50) were divided into the three groups: the group A (n=15, insertion of the unflated Fogarty balloon catheter), the group B (n=15, insertion of the Fogarty balloon catheter at a volume of 20 μL) and the group C (n=15, insertion of the Fogarty balloon catheter at a volume of 50 μL). After the behavioral test, RNA isolation, microRNA expression profiling using microarrays and quantitative polymerase chain reaction, measurements were compared between the three groups.
Results Despite a lack of significant differences in time-dependent changes in miRNA-21 expression levels between the three groups at 4 hours, there were significant differences in them at 1, 3, and 7 days (p<0.05). Moreover, there were significant differences in time-dependent changes in miRNA-223 expression levels between the three groups at 4 hours and 1, 3, and 7 days (p<0.05). Furthermore, miRNA-223 expression levels reached the highest at 1 day but were decreased with time thereafter in all the three groups.
Conclusion Expression levels of miRNA-21 and miRNA-223 might be associated with the severity and acute phase of SCI, respectively. It is mandatory, however, to analyze changes in levels of inflammatory markers and the relevant biological pathways.
Long non-coding RNA-small nucleolar RNA host gene 7 regulates inflammatory responses following spinal cord injury by regulating the microRNA-449a/TNF-α-induced protein 3-interacting protein 2 axis Chunlei He, Jianhua Xiao, Yongjun Ye, Shiqiao Huang, Yanchun Zhong, Lulin Liu, Wuyang Liu, Sheng Liu Bioengineered.2022; 13(4): 10215. CrossRef
Improving Diagnostic Workup Following Traumatic Spinal Cord Injury: Advances in Biomarkers Simon Schading, Tim M. Emmenegger, Patrick Freund Current Neurology and Neuroscience Reports.2021;[Epub] CrossRef
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