Annals of Rehabilitation Medicine

"Hyunseok Lee"

Original Article

Association Between a Polymorphism in CASP3 and CASP9 Genes and Ischemic Stroke: Bae Youl Lee, Jinmann Chon, Hee-Sang Kim, Jong Ha Lee, Dong Hwan Yun, Seung Don Yoo, Dong Hwan Kim, Seung Ah Lee, Yoo Jin Han, Hyunseok Lee, Jin Chul Kim, Yunsoo Soh, Joo-Ho Chung, Su Kang Kim, Hae Jeong Park; Ann Rehabil Med 2017;41(2):197-203. Published online April 27, 2017; DOI: https://doi.org/10.5535/arm.2017.41.2.197

Abstract
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Objective

To investigate whether the polymorphisms of CASP3 gene (rs4647602, intron A/C and rs1049216, UTR C/T) and CASP9 gene (rs1052576, Gln/Arg G/A and rs1052571, Ser/Val T/C) were associated with the development, and clinical severity of ischemic stroke and functional consequences after stroke.

Methods

Genomic DNA from 121 ischemic stroke patients and 201 healthy control subjects were extracted, and polymerase chain reaction products were sequenced. To investigate the association of polymorphisms and the development, and National Institutes of Health Stroke Scale (K-NIHSS), logistic regression models were analyzed.

Results

Polymorphism of the untranslational region of CASP3 (rs1049216, UTR C/T) has been associated with the development of ischemic stroke—in codominant1 model (odds ratio [OR], 0.51; 95% confidence interval [CI], 0.29–0.88; p=0.017), in dominant model (OR, 0.57; 95% CI, 0.34–0.97; p=0.034), and in the overdominant model (OR, 0.50; 95% CI, 0.29–0.87; p=0.011). A missense SNP of CASP9 gene (rs1052571, Ser/Val T/C) was associated with the development of ischemic stroke (OR, 1.93; 95% CI, 1.05–3.55; p=0.034 in recessive model).

Conclusion

These results indicate the possibility that CASP3 and CASP9 genes are markers for the development of ischemic stroke.

Citations

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