Clonidine, centrally acting α₂ agonist, has been used as an antihypertensive agent. Although antispastic action of clonidine has been known, the clinical use of oral clonidine on spinal spasticity has been limited due to side effects, mainly postural hypotension. Two cases are presented of patients with spasticity as the result of cervical spinal cord injury, inadequately managed by oral baclofen & other conservative treatment, in whom transdermal clonidine was administered. Dramatic relief in spasticity and increment in functional level were achieved in both of 2 cases with side effect limited to dryness of the mouth in one case. In addition to improvement in spasticity, there was amelioration of paresthesia in one case.