The authors studied 60 children (aged 4 months to 9 years) with cerebral palsy by means of magnetic resonance imaging (MRI) and single photon emission computed tomography (SPECT) of the brain. MRI showed normal in 15 cases (25.0%) and deep white matter pathology in 37 cases (61.7%), corpus callosum abnormality in 29 cases (48.3%). In addition, abnormal intensity of thalamus or basal ganglia and delayed myelination were found in minor cases. In all of the patients except for 1 case, SPECT showed the abnormal findings SPECT demonstrated hypoperfusion of thalamus in 58 cases (96.7%), cerebellum in 27 cases (45.0%), frontal and parietal lobe in 26 cases (43.3%), basal ganglia in 23 cases (38.3%) and temporal lobe in 22 cases (36.7%). There was no significant correlation between the severity of motor developmental impairment and the radiologic findings. The results of this study suggest that MRI of the brain provides the anatomical information such as deep white matter and corpus callosum pathologies resulted from the hypoxic-ischemic insult and SPECT of the brain is a very sensitive tool for the assessment of the functional abnormalities in cerebral palsy.